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acacb acetyl-CoA carboxylase beta [ Danio rerio (zebrafish) ]

Gene ID: 556236, updated on 27-Mar-2024

Summary

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Official Symbol
acacbprovided by ZNC
Official Full Name
acetyl-CoA carboxylase betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-132
See related
Ensembl:ENSDARG00000061994 AllianceGenome:ZFIN:ZDB-GENE-060526-132
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-250o15.3
Summary
Predicted to enable ATP binding activity; acetyl-CoA carboxylase activity; and metal ion binding activity. Predicted to be involved in malonyl-CoA biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Is expressed in liver. Orthologous to human ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See acacb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
55
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (19331276..19384527)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (18826542..18879878)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B5a Neighboring gene RUN and SH3 domain containing 2 Neighboring gene uncharacterized LOC103911062 Neighboring gene uncharacterized LOC103911063 Neighboring gene forkhead box N4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Hasumura T, et al. Nutr Metab (Lond), 2012 Aug 7. PMID 22871059, Free PMC Article
  2. Probing the hepatotoxicity mechanisms of novel chlorinated polyfluoroalkyl sulfonates to zebrafish larvae: Implication of structural specificity. Yi S, et al. Environ Int, 2019 Dec. PMID 31665679
  3. Developmental toxicity of the common UV filter, benophenone-2, in zebrafish embryos. Fong HC, et al. Chemosphere, 2016 Dec. PMID 27599007
  4. Development of an Animal Model for Alcoholic Liver Disease in Zebrafish. Lin JN, et al. Zebrafish, 2015 Aug. PMID 25923904
  5. Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos. Ho JCH, et al. Aquat Toxicol, 2016 Apr. PMID 26828895

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetyl-CoA carboxylase 2
XP_021332107.1
XP_021332108.1
XP_021332109.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    19331276..19384527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476432.1 → XP_021332107.1  acetyl-CoA carboxylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PKW2
    Related
    ENSDARP00000083511.5, ENSDART00000089078.6
    Conserved Domains (4) summary
    COG0439
    Location:164 → 667
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:799 → 865
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1708 → 2262
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:866 → 1609
    ACC_central; Acetyl-CoA carboxylase, central region

  2. XM_021476433.1 → XP_021332108.1  acetyl-CoA carboxylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PYI5
    Conserved Domains (4) summary
    COG0439
    Location:164 → 667
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:799 → 865
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1694 → 2248
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:866 → 1595
    ACC_central; Acetyl-CoA carboxylase, central region

  3. XM_021476434.1 → XP_021332109.1  acetyl-CoA carboxylase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q417
    Related
    ENSDARP00000113940.1, ENSDART00000148130.2
    Conserved Domains (4) summary
    COG0439
    Location:164 → 667
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:799 → 865
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1686 → 2240
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:866 → 1587
    ACC_central; Acetyl-CoA carboxylase, central region
Nucleotide Protein
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