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cblb Cbl proto-oncogene B, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

Gene ID: 556277, updated on 27-Mar-2024

Summary

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Official Symbol
cblbprovided by ZNC
Official Full Name
Cbl proto-oncogene B, E3 ubiquitin protein ligaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-417
See related
Ensembl:ENSDARG00000015199 AllianceGenome:ZFIN:ZDB-GENE-030616-417
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CBL; Cas-Br-M; dZ25N23.1; si:dz25n23.1; si:dz39l02.2; si:busm1-25n23.1; si:busm1-39l02.2
Summary
Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and regulation of signaling. Predicted to be located in cytoplasm. Predicted to be active in membrane raft and plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cblb in Genome Data Viewer
Location:
chromosome: 10
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (28587496..28731667)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (28700881..28844995)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911768 Neighboring gene BBX, HMG-box containing Neighboring gene uncharacterized LOC110440072 Neighboring gene uncharacterized LOC110440073 Neighboring gene uncharacterized LOC101883380 Neighboring gene uncharacterized LOC103911755 Neighboring gene activated leukocyte cell adhesion molecule a Neighboring gene si:ch211-103f14.3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation of immune responses by E3 ubiquitin-protein ligases. Fang N, et al. Curr Dir Autoimmun, 2002. PMID 11826757
  2. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
ectopic retroviral transforming
retroviral transforming sequence
XP_001921961.4
XP_021327977.1
XP_021329887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    28587496..28731667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001921926.7 → XP_001921961.4  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A8M1QR09, F1Q742
    Related
    ENSDARP00000033942.9, ENSDART00000030138.10
    Conserved Domains (5) summary
    cd09920
    Location:243 → 339
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:368 → 410
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:891 → 931
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:39 → 162
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:166 → 249
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394789.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    322222..385850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472302.1 → XP_021327977.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A8M9PAD4
    Conserved Domains (2) summary
    pfam02262
    Location:39 → 162
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:166 → 184
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395290.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    112132..238155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474212.1 → XP_021329887.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9PFD0
    Conserved Domains (5) summary
    cd09920
    Location:243 → 339
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:891 → 931
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:39 → 162
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:166 → 249
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:349 → 414
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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