U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF446 zinc finger protein 446 [ Homo sapiens (human) ]

Gene ID: 55663, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF446provided by HGNC
Official Full Name
zinc finger protein 446provided by HGNC
Primary source
HGNC:HGNC:21036
See related
Ensembl:ENSG00000083838 AllianceGenome:HGNC:21036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN30; ZSCAN52; ZKSCAN20
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 4.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF446 in Genome Data Viewer
Location:
19q13.43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58476352..58489533)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61572319..61585623)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58987719..59000900)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 324B Neighboring gene zinc finger protein 250 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58962695-58963021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978178-58978794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978795-58979409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15199 Neighboring gene zinc finger protein 324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15201 Neighboring gene Sharpr-MPRA regulatory region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15203 Neighboring gene uncharacterized LOC112268251 Neighboring gene RNA, U6 small nuclear 1337, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4347 Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15206 Neighboring gene solute carrier family 27 member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:59017967-59018180

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. Liu F, et al. Biochem Biophys Res Commun, 2005 Jul 22. PMID 15936718
  2. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. Martínez-Noël G, et al. J Mol Biol, 2018 Mar 30. PMID 29426014, Free PMC Article
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Corominas R, et al. Nat Commun, 2014 Apr 11. PMID 24722188, Free PMC Article
  5. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of ZNF446 in COS-7 cells inhibits the transcriptional activities of SRE and AP-1.
    Title: A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ17426, FLJ20626

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in extracellular space HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 446
Names
zinc finger protein with KRAB and SCAN domains 20

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304453.1 → NP_001291382.1  zinc finger protein 446 isoform 2

    See identical proteins and their annotated locations for NP_001291382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a shorter 5' UTR and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AL833955, BQ441187, DA162028
    UniProtKB/TrEMBL
    Q8NDK2
    Conserved Domains (3) summary
    smart00431
    Location:22 → 137
    SCAN; leucine rich region
    pfam01352
    Location:209 → 237
    KRAB; KRAB box
    pfam02023
    Location:22 → 110
    SCAN; SCAN domain

  2. NM_017908.4 → NP_060378.1  zinc finger protein 446 isoform 1

    See identical proteins and their annotated locations for NP_060378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK000633, AL122108, DA162028
    Consensus CDS
    CCDS12982.1
    UniProtKB/Swiss-Prot
    Q96AF5, Q9NWS9
    UniProtKB/TrEMBL
    M0R202
    Related
    ENSP00000472802.1, ENST00000594369.6
    Conserved Domains (3) summary
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:209 → 238
    KRAB; KRAB box
    cl02605
    Location:22 → 137
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58476352..58489533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61572319..61585623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWS9.1 GenPept UniProtKB/Swiss-Prot:Q9NWS9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous