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CNDP2 carnosine dipeptidase 2 [ Homo sapiens (human) ]

Gene ID: 55748, updated on 3-Apr-2024

Summary

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Official Symbol
CNDP2provided by HGNC
Official Full Name
carnosine dipeptidase 2provided by HGNC
Primary source
HGNC:HGNC:24437
See related
Ensembl:ENSG00000133313 MIM:169800; AllianceGenome:HGNC:24437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CN2; CPGL; PEPA; HsT2298; HEL-S-13
Summary
CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in kidney (RPKM 58.4), small intestine (RPKM 41.5) and 24 other tissues See more
Orthologs
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Genomic context

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See CNDP2 in Genome Data Viewer
Location:
18q22.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (74496363..74523454)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (74723735..74750816)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72163598..72190689)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:72079090-72079848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:72079849-72080607 Neighboring gene long intergenic non-protein coding RNA 1922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72112405-72112906 Neighboring gene divergent protein kinase domain 1C Neighboring gene CRISPRi-validated cis-regulatory element chr18.1476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:72163711-72164223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72177239-72177740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72177741-72178240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72208118-72208618 Neighboring gene carnosine dipeptidase 1 Neighboring gene uncharacterized LOC124904324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13500 Neighboring gene ZNF407 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway. Zhang LQ, et al. Technol Cancer Res Treat, 2019 Jan 1. PMID 31537175, Free PMC Article
  2. The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase activity but its substrate specificity is different from that of the manganese form. Okumura N, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29056506
  3. Up-regulation of CNDP2 facilitates the proliferation of colon cancer. Xue C, et al. BMC Gastroenterol, 2014 May 21. PMID 24885395, Free PMC Article
  4. Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway. Zhang Z, et al. Mol Med, 2014 Mar 13. PMID 24395568, Free PMC Article
  5. Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease. Licker V, et al. J Proteomics, 2012 Aug 3. PMID 22410244

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exploring the structural and dynamic differences between human carnosinase I (CN1) and II (CN2).
    Title: Exploring the structural and dynamic differences between human carnosinase I (CN1) and II (CN2).
  2. Cytosolic nonspecific dipeptidase 2 promotes the occurrence and development of ovarian cancer through the PI3K/AKT signaling pathway.
    Title: CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.
  3. 2 SNPs (rs7244647 in CNDP1 and rs4891558 in CNDP2) were associated with obesity risk. In addition, these associations were observed only in the group with high carbohydrate and low carotene intake but not in the group with low carbohydrate and high carotene intake.
    Title: The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk.
  4. The CNDP2 rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 rs3764509, CNDP2-CNDP1 rs2346061, and CNDP1 rs2887) were overrepresented in power athletes compared with nonathletes.
    Title: Single Nucleotide Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) are Associated With Power Athletic Status.
  5. These results suggest that the zinc form of CN2 is an active enzyme, but with a different substrate specificity from that of the manganese form.
    Title: The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase activity but its substrate specificity is different from that of the manganese form.
  6. To identify substrates of orphan transporter ATP-binding cassette subfamily C member 5 (ABCC5), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation.
    Title: N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.
  7. Expression of CN2 in clinical colon tumors and colon cancer cell lines was significantly higher than that in normal colon mucosa cell lines. Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo.
    Title: Up-regulation of CNDP2 facilitates the proliferation of colon cancer.
  8. Results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.
    Title: Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway.
  9. a key role of CNDP2 in PD neurodegeneration, by mechanisms that could involve oxidative stress, protein aggregation or inflammation.
    Title: Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease.
  10. deletion of the CPGL gene is a poor prognostic marker in resected pancreatic cancer, and functional studies suggest the CPGL gene as growth suppressor gene in pancreatic cancer.
    Title: Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10830, FLJ35544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alanylglutamate dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
cytosolic non-specific dipeptidase
Names
CNDP dipeptidase 2 (metallopeptidase M20 family)
carnosinase-2
carnosine dipeptidase II
cytosolic nonspecific dipeptidase
epididymis secretory protein Li 13
glutamate carboxypeptidase-like protein 1
peptidase A
threonyl dipeptidase
NP_001161971.1
NP_001357177.1
NP_001357178.1
NP_001357179.1
NP_001357183.1
NP_060705.2
XP_047293579.1
XP_047293580.1
XP_054174780.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168499.2 → NP_001161971.1  cytosolic non-specific dipeptidase isoform 2

    See identical proteins and their annotated locations for NP_001161971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC009704, AF258592, BM675304
    Consensus CDS
    CCDS54190.1
    UniProtKB/TrEMBL
    B4DV28
    Related
    ENSP00000325756.8, ENST00000324301.12
    Conserved Domains (2) summary
    PRK08201
    Location:10 → 389
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:7 → 389
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

  2. NM_001370248.1 → NP_001357177.1  cytosolic non-specific dipeptidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, BQ223281
    Consensus CDS
    CCDS12006.1
    UniProtKB/Swiss-Prot
    B3KUG4, Q8WY59, Q96KP4, Q9BQ94, Q9NVB4, V9HWE5
    UniProtKB/TrEMBL
    B4DV28
    Related
    ENSP00000462311.1, ENST00000579847.5
    Conserved Domains (1) summary
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

  3. NM_001370249.1 → NP_001357178.1  cytosolic non-specific dipeptidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, BQ223281
    Consensus CDS
    CCDS12006.1
    UniProtKB/Swiss-Prot
    B3KUG4, Q8WY59, Q96KP4, Q9BQ94, Q9NVB4, V9HWE5
    UniProtKB/TrEMBL
    B4DV28
    Conserved Domains (1) summary
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

  4. NM_001370250.1 → NP_001357179.1  cytosolic non-specific dipeptidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, BQ223281
    Consensus CDS
    CCDS12006.1
    UniProtKB/Swiss-Prot
    B3KUG4, Q8WY59, Q96KP4, Q9BQ94, Q9NVB4, V9HWE5
    UniProtKB/TrEMBL
    B4DV28
    Conserved Domains (1) summary
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

  5. NM_001370254.1 → NP_001357183.1  cytosolic non-specific dipeptidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009704, BC001375, DC313148
    Conserved Domains (1) summary
    cl14876
    Location:1 → 234
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  6. NM_018235.3 → NP_060705.2  cytosolic non-specific dipeptidase isoform 1

    See identical proteins and their annotated locations for NP_060705.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AC009704, BC001375, BM675304, DC313148
    Consensus CDS
    CCDS12006.1
    UniProtKB/Swiss-Prot
    B3KUG4, Q8WY59, Q96KP4, Q9BQ94, Q9NVB4, V9HWE5
    UniProtKB/TrEMBL
    B4DV28
    Related
    ENSP00000325548.4, ENST00000324262.9
    Conserved Domains (1) summary
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    74496363..74523454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437624.1 → XP_047293580.1  cytosolic non-specific dipeptidase isoform X1

    UniProtKB/Swiss-Prot
    B3KUG4, Q8WY59, Q96KP4, Q9BQ94, Q9NVB4, V9HWE5

  2. XM_047437623.1 → XP_047293579.1  cytosolic non-specific dipeptidase isoform X1

    UniProtKB/Swiss-Prot
    B3KUG4, Q8WY59, Q96KP4, Q9BQ94, Q9NVB4, V9HWE5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    74723735..74750816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318805.1 → XP_054174780.1  cytosolic non-specific dipeptidase isoform X1

    UniProtKB/Swiss-Prot
    B3KUG4, Q8WY59, Q96KP4, Q9BQ94, Q9NVB4, V9HWE5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KP4.2 GenPept UniProtKB/Swiss-Prot:Q96KP4

Gene LinkOut

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