tnnt1 troponin T type 1 (skeletal, slow) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnnt1provided by ZNC
Official Full Name: troponin T type 1 (skeletal, slow)provided by ZNC
Primary source: ZFIN:ZDB-GENE-080723-27
See related: Ensembl:ENSDARG00000037954 AllianceGenome:ZFIN:ZDB-GENE-080723-27
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:193831; zgc:193865
Summary: Predicted to enable tropomyosin binding activity and troponin T binding activity. Acts upstream of or within sarcomere organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of troponin complex. Is expressed in muscle and slow muscle cell. Human ortholog(s) of this gene implicated in nemaline myopathy 5. Orthologous to human TNNT1 (troponin T1, slow skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32157140..32171469, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32025426..32039764, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A zebrafish loss-of-function model using morpholinos was created to assess the pathogenicity of the identified variant. Wild-type or mutated human TNNT1 mRNAs were coinjected with morpholinos to assess their abilities to rescue the morphant phenotype. Wild-type TNNT1 mRNA rescued the zebrafish morphants, but mutant transcripts failed to do so.
Title: Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin T binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in slow-twitch skeletal muscle fiber contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: troponin T, slow skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128695.1 → NP_001122167.1 troponin T, slow skeletal muscle

See identical proteins and their annotated locations for NP_001122167.1

Status: PROVISIONAL

Source sequence(s)

BC162595

UniProtKB/TrEMBL

B3DG30, B3DH09, F6P6G5

Related

ENSDARP00000055306.4, ENSDART00000055307.5

Conserved Domains (1) summary

pfam00992
Location:75 → 210

Troponin; Troponin

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

32157140..32171469 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470805.1 → XP_021326480.1 troponin T, slow skeletal muscle isoform X1

UniProtKB/TrEMBL

A0A8M9PZE1

Conserved Domains (1) summary

pfam00992
Location:73 → 208

Troponin
XM_021470807.1 → XP_021326482.1 troponin T, slow skeletal muscle isoform X2

UniProtKB/TrEMBL

A0A8M9P738

Conserved Domains (1) summary

pfam00992
Location:66 → 201

Troponin