gbe1b glucan (1,4-alpha-), branching enzyme 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gbe1bprovided by ZNC
Official Full Name: glucan (1,4-alpha-), branching enzyme 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-110914-16
See related: Ensembl:ENSDARG00000099524 AllianceGenome:ZFIN:ZDB-GENE-110914-16
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gbe1; si:ch211-247m23.1
Summary: Predicted to enable 1,4-alpha-glucan branching enzyme activity. Predicted to be involved in glycogen biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease IV and pulmonary tuberculosis. Orthologous to human GBE1 (1,4-alpha-glucan branching enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (7353421..7598480, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (7377333..7622406, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1,4-alpha-glucan branching enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1,4-alpha-glucan branching enzyme activity	IEA Inferred from Electronic Annotation more info
enables 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cation binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 1,4-alpha-glucan-branching enzyme

Names: glucan (1,4-alpha-), branching enzyme 1

XP_009289773.1

EC 2.4.1.18

XP_009289774.1

EC 2.4.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

7353421..7598480 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291498.3 → XP_009289773.1 1,4-alpha-glucan-branching enzyme isoform X1

UniProtKB/TrEMBL

A0A8M3AIA9

Related

ENSDARP00000137627.2, ENSDART00000165898.3

Conserved Domains (4) summary

cd02854
Location:68 → 163

E_set_GBE_euk_N; N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme)

cd11321
Location:165 → 570

AmyAc_bac_euk_BE; Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes

COG0296
Location:56 → 681

GlgB; 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]

pfam02806
Location:588 → 683

Alpha-amylase_C; Alpha amylase, C-terminal all-beta domain
XM_009291499.2 → XP_009289774.1 1,4-alpha-glucan-branching enzyme isoform X2

UniProtKB/TrEMBL

A0A8M3ASH5

Conserved Domains (2) summary

pfam02806
Location:258 → 353

Alpha-amylase_C; Alpha amylase, C-terminal all-beta domain

cl07893
Location:1 → 240

AmyAc_family; Alpha amylase catalytic domain family