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rnf216 ring finger protein 216 [ Danio rerio (zebrafish) ]

Gene ID: 559441, updated on 27-Mar-2024

Summary

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Official Symbol
rnf216provided by ZNC
Official Full Name
ring finger protein 216provided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-199
See related
Ensembl:ENSDARG00000087893 AllianceGenome:ZFIN:ZDB-GENE-081104-199
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-255l18.3
Summary
Predicted to enable metal ion binding activity and transferase activity. Acts upstream of or within camera-type eye development and cerebellum development. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (40605119..40664888, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (40463261..40523030, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene actin, beta 2 Neighboring gene fascin actin-bundling protein 1a Neighboring gene urotensin-2 receptor 5 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. Margolin DH, et al. N Engl J Med, 2013 May 23. PMID 23656588, Free PMC Article
  2. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellum development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF216
XP_687871.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    40605119..40664888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_682779.8 → XP_687871.3  E3 ubiquitin-protein ligase RNF216

    UniProtKB/TrEMBL
    A0A8N7TEK8, E7F859
    Related
    ENSDARP00000117304.1, ENSDART00000138783.2
    Conserved Domains (1) summary
    pfam17061
    Location:77 → 212
    PARM; PARM
Nucleotide Protein Strain
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