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ptprja protein tyrosine phosphatase receptor type Ja [ Danio rerio (zebrafish) ]

Gene ID: 559679, updated on 11-Apr-2024

Summary

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Official Symbol
ptprjaprovided by ZNC
Official Full Name
protein tyrosine phosphatase receptor type Japrovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8301
See related
Ensembl:ENSDARG00000033042 AllianceGenome:ZFIN:ZDB-GENE-030131-8301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dep1a; fb08b12; wu:fb08b12
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within artery morphogenesis and thrombocyte differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in blood vessel endothelial cell; brain; and muscle. Used to study thrombocytopenia. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ptprja in Genome Data Viewer
Location:
chromosome: 7
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (39552805..39611224, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39281788..39340205, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene otogelin Neighboring gene solute carrier family 22 member 18 Neighboring gene protein tyrosine phosphatase non-receptor type 5 Neighboring gene KIAA0232

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia. Marconi C, et al. Blood, 2019 Mar 21. PMID 30591527
  2. The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish development. Rodriguez F, et al. Dev Biol, 2008 Dec 1. PMID 18835554
  3. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
  4. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article
  5. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within thrombocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase eta
Names
density-enhanced phosphatase-1a
protein tyrosine phosphatase, receptor type, J a
NP_001129714.1
XP_005166490.1
XP_005166491.1
XP_021333228.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136242.1 → NP_001129714.1  receptor-type tyrosine-protein phosphatase eta precursor

    See identical proteins and their annotated locations for NP_001129714.1

    Status: PROVISIONAL

    Source sequence(s)
    AM988860
    UniProtKB/TrEMBL
    A0A8M1NIV9, B6HY54
    Related
    ENSDARP00000124678.1, ENSDART00000149991.2
    Conserved Domains (6) summary
    smart00060
    Location:968 → 1031
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1355 → 1611
    PTPc; Protein tyrosine phosphatase, catalytic domain
    COG3979
    Location:275 → 427
    COG3979; Chitodextrinase [Carbohydrate transport and metabolism]
    cd00047
    Location:1383 → 1611
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:182 → 255
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:278 → 353
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    39552805..39611224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477553.1 → XP_021333228.1  receptor-type tyrosine-protein phosphatase eta isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q1N4
    Conserved Domains (5) summary
    smart00060
    Location:1001 → 1064
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1388 → 1644
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00063
    Location:395 → 474
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:311 → 386
    fn3; Fibronectin type III domain
    cl21522
    Location:740 → 816
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_005166433.4 → XP_005166490.1  receptor-type tyrosine-protein phosphatase eta isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDT9
    Conserved Domains (6) summary
    smart00060
    Location:1084 → 1147
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1471 → 1727
    PTPc; Protein tyrosine phosphatase, catalytic domain
    COG3979
    Location:391 → 543
    COG3979; Chitodextrinase [Carbohydrate transport and metabolism]
    cd00047
    Location:1499 → 1727
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:298 → 371
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:394 → 469
    fn3; Fibronectin type III domain

  3. XM_005166434.4 → XP_005166491.1  receptor-type tyrosine-protein phosphatase eta isoform X2

    UniProtKB/TrEMBL
    A0A8M2BE01
    Conserved Domains (6) summary
    smart00060
    Location:1084 → 1147
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1471 → 1727
    PTPc; Protein tyrosine phosphatase, catalytic domain
    COG3979
    Location:391 → 543
    COG3979; Chitodextrinase [Carbohydrate transport and metabolism]
    cd00047
    Location:1499 → 1727
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:298 → 371
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:394 → 469
    fn3; Fibronectin type III domain
Nucleotide Protein
Heading Accession and Version

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