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MAPK7 mitogen-activated protein kinase 7 [ Homo sapiens (human) ]

Gene ID: 5598, updated on 11-Apr-2024

Summary

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Official Symbol
MAPK7provided by HGNC
Official Full Name
mitogen-activated protein kinase 7provided by HGNC
Primary source
HGNC:HGNC:6880
See related
Ensembl:ENSG00000166484 MIM:602521; AllianceGenome:HGNC:6880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMK1; ERK4; ERK5; PRKM7
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19377750..19383544)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19325785..19331579)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19281063..19286857)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene B9 domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 2588 Neighboring gene microRNA 1180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19261015-19261514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8288 Neighboring gene uncharacterized LOC105371573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19266095-19266879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19275949-19276498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19283774-19284736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19285982-19286482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19286483-19286983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19288791-19289336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289337-19289882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289883-19290428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19294419-19295332 Neighboring gene microfibril associated protein 4 Neighboring gene uncharacterized LOC124903947 Neighboring gene ring finger protein 112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications. Sánchez-Fdez A, et al. Exp Mol Med, 2023 Jun. PMID 37332046, Free PMC Article
  2. The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk. Cacina C, et al. In Vivo, 2023 Mar-Apr. PMID 36881097, Free PMC Article
  3. Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity. Ippolito F, et al. Cell Death Dis, 2023 Jan 17. PMID 36650140, Free PMC Article
  4. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Kotla S, et al. Redox Biol, 2021 Nov. PMID 34619528, Free PMC Article
  5. Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells. Gentilini A, et al. Hepatology, 2021 Oct. PMID 33959996, Free PMC Article

See all (231) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
    Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
  2. An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.
    Title: An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.
  3. ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells.
    Title: ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells.
  4. MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.
    Title: MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.
  5. Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition.
    Title: Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition.
  6. Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications.
    Title: Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications.
  7. VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
    Title: VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
  8. The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk.
    Title: The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk.
  9. Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity.
    Title: Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity.
  10. Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5.
    Title: Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5.
Submit: New GeneRIF Correction See all GeneRIFs (169)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme inhibitor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to laminar fluid shear stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to laminar fluid shear stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of heterotypic cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of response to cytokine stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of smooth muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 7
Names
BMK-1
BMK1 kinase
ERK-5
MAP kinase 7
MAPK 7
big MAP kinase 1
extracellular-signal-regulated kinase 5
NP_002740.2
NP_620601.1
NP_620602.2
NP_620603.2
XP_006721620.1
XP_006721621.1
XP_006721622.1
XP_011522259.1
XP_047292357.1
XP_047292358.1
XP_047292359.1
XP_047292360.1
XP_047292361.1
XP_047292362.1
XP_047292363.1
XP_054172645.1
XP_054172646.1
XP_054172647.1
XP_054172648.1
XP_054172649.1
XP_054172650.1
XP_054172651.1
XP_054172652.1
XP_054172653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002749.4 → NP_002740.2  mitogen-activated protein kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_002740.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is also known as BMK1 gamma. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
    Source sequence(s)
    BC009963, BC030134, DA452383
    Consensus CDS
    CCDS11206.1
    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
    UniProtKB/TrEMBL
    B4DI23
    Related
    ENSP00000378968.3, ENST00000395604.8
    Conserved Domains (2) summary
    smart00220
    Location:55 → 347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49 → 384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  2. NM_139032.3 → NP_620601.1  mitogen-activated protein kinase 7 isoform 2

    See identical proteins and their annotated locations for NP_620601.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' region, which includes the translation start codon, when compared to variant 1. The translation of this transcript begins at a downstream in-frame start codon, and thus results in an N-terminal truncated isoform (2), as compared to isoform 1.
    Source sequence(s)
    BC007404, BC030134, DB133227
    Consensus CDS
    CCDS11207.1
    UniProtKB/Swiss-Prot
    Q13164
    Related
    ENSP00000299612.7, ENST00000299612.11
    Conserved Domains (2) summary
    smart00220
    Location:4 → 208
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  3. NM_139033.3 → NP_620602.2  mitogen-activated protein kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_620602.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is also known as BMK1 alpha. It encodes a longer isoform (1), as compared to variant 2. Variants 1, 3 and 4 encode the same isoform.
    Source sequence(s)
    BC030134, DB133227, U29725
    Consensus CDS
    CCDS11206.1
    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
    UniProtKB/TrEMBL
    B4DI23
    Related
    ENSP00000311005.5, ENST00000308406.9
    Conserved Domains (2) summary
    smart00220
    Location:55 → 347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49 → 384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  4. NM_139034.3 → NP_620603.2  mitogen-activated protein kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_620603.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is also known as BMK1 beta. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
    Source sequence(s)
    BC030134, U29726
    Consensus CDS
    CCDS11206.1
    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
    UniProtKB/TrEMBL
    B4DI23
    Related
    ENSP00000378966.4, ENST00000395602.8
    Conserved Domains (2) summary
    smart00220
    Location:55 → 347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49 → 384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    19377750..19383544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721558.4 → XP_006721621.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006721621.1

    UniProtKB/TrEMBL
    B4DI23
    Conserved Domains (2) summary
    smart00220
    Location:55 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49 → 390
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  2. XM_047436404.1 → XP_047292360.1  mitogen-activated protein kinase 7 isoform X2

    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
    Related
    ENST00000490660.2

  3. XM_047436402.1 → XP_047292358.1  mitogen-activated protein kinase 7 isoform X1

  4. XM_047436406.1 → XP_047292362.1  mitogen-activated protein kinase 7 isoform X2

    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

  5. XM_006721557.4 → XP_006721620.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006721620.1

    UniProtKB/TrEMBL
    B4DI23
    Conserved Domains (2) summary
    smart00220
    Location:55 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49 → 390
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  6. XM_047436403.1 → XP_047292359.1  mitogen-activated protein kinase 7 isoform X1

  7. XM_047436405.1 → XP_047292361.1  mitogen-activated protein kinase 7 isoform X2

    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

  8. XM_006721559.4 → XP_006721622.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006721622.1

    UniProtKB/TrEMBL
    B4DI23
    Conserved Domains (2) summary
    smart00220
    Location:55 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49 → 390
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  9. XM_011523957.4 → XP_011522259.1  mitogen-activated protein kinase 7 isoform X4

    See identical proteins and their annotated locations for XP_011522259.1

    UniProtKB/Swiss-Prot
    Q13164
    Conserved Domains (2) summary
    smart00220
    Location:4 → 208
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  10. XM_047436407.1 → XP_047292363.1  mitogen-activated protein kinase 7 isoform X3

  11. XM_047436401.1 → XP_047292357.1  mitogen-activated protein kinase 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    19325785..19331579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316672.1 → XP_054172647.1  mitogen-activated protein kinase 7 isoform X1

  2. XM_054316673.1 → XP_054172648.1  mitogen-activated protein kinase 7 isoform X1

  3. XM_054316676.1 → XP_054172651.1  mitogen-activated protein kinase 7 isoform X2

    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

  4. XM_054316670.1 → XP_054172645.1  mitogen-activated protein kinase 7 isoform X1

  5. XM_054316674.1 → XP_054172649.1  mitogen-activated protein kinase 7 isoform X1

  6. XM_054316675.1 → XP_054172650.1  mitogen-activated protein kinase 7 isoform X2

    UniProtKB/Swiss-Prot
    Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

  7. XM_054316671.1 → XP_054172646.1  mitogen-activated protein kinase 7 isoform X1

  8. XM_054316678.1 → XP_054172653.1  mitogen-activated protein kinase 7 isoform X4

  9. XM_054316677.1 → XP_054172652.1  mitogen-activated protein kinase 7 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13164.2 GenPept UniProtKB/Swiss-Prot:Q13164

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