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Pigb phosphatidylinositol glycan anchor biosynthesis, class B [ Mus musculus (house mouse) ]

Gene ID: 55981, updated on 12-May-2024

Summary

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Official Symbol
Pigbprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Bprovided by MGI
Primary source
MGI:MGI:1891825
See related
Ensembl:ENSMUSG00000079469 AllianceGenome:MGI:1891825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pig-b
Summary
Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and mannosylation. Predicted to act upstream of or within GPI anchor metabolic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 80. Orthologous to human PIGB (phosphatidylinositol glycan anchor biosynthesis class B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.0), frontal lobe adult (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 D; 9 40.08 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72920639..72946973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (73015301..73039723, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 4 Neighboring gene predicted gene, 23567 Neighboring gene STARR-positive B cell enhancer ABC_E3843 Neighboring gene piercer of microtubule wall 2 Neighboring gene STARR-seq mESC enhancer starr_24620 Neighboring gene cell cycle progression 1 Neighboring gene Pigb opposite strand 1 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_24625 Neighboring gene STARR-seq mESC enhancer starr_24627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. Takahashi M, et al. EMBO J, 1996 Aug 15. PMID 8861954, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within GPI anchor metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mannosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI mannosyltransferase 3
Names
GPI mannosyltransferase III
GPI-MT-III
involved in GPI-anchor biosynthesis
phosphatidylinositol glycan, class B
phosphatidylinositol-glycan biosynthesis class B protein
NP_001397577.1
NP_061377.2
XP_006511350.1
XP_011241075.1
XP_036011033.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410648.1 → NP_001397577.1  GPI mannosyltransferase 3

    Status: VALIDATED

    Source sequence(s)
    AC158997
    UniProtKB/Swiss-Prot
    Q3U585, Q7TQ01, Q9JJQ0
    Related
    ENSMUSP00000139269.2, ENSMUST00000184035.8

  2. NM_018889.4 → NP_061377.2  GPI mannosyltransferase 3

    See identical proteins and their annotated locations for NP_061377.2

    Status: VALIDATED

    Source sequence(s)
    AC158997
    Consensus CDS
    CCDS40687.1
    UniProtKB/Swiss-Prot
    Q3U585, Q7TQ01, Q9JJQ0
    Related
    ENSMUSP00000138885.2, ENSMUST00000183746.8
    Conserved Domains (1) summary
    cl21590
    Location:39 → 529
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    72920639..72946973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155140.1 → XP_036011033.1  GPI mannosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    cl21590
    Location:159 → 416
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. XM_006511287.5 → XP_006511350.1  GPI mannosyltransferase 3 isoform X3

    Conserved Domains (1) summary
    cl21590
    Location:51 → 254
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  3. XM_011242773.4 → XP_011241075.1  GPI mannosyltransferase 3 isoform X4

    Conserved Domains (1) summary
    cl21590
    Location:51 → 273
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RNA

  1. XR_379430.5 RNA Sequence

  2. XR_870761.4 RNA Sequence

  3. XR_379431.5 RNA Sequence

  4. XR_379429.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJQ0.2 GenPept UniProtKB/Swiss-Prot:Q9JJQ0

Gene LinkOut

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