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daxx death-domain associated protein [ Danio rerio (zebrafish) ]

Gene ID: 561006, updated on 11-Apr-2024

Summary

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Official Symbol
daxxprovided by ZNC
Official Full Name
death-domain associated proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010110-3
See related
Ensembl:ENSDARG00000000729 AllianceGenome:ZFIN:ZDB-GENE-010110-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fd15c03; si:dz179b20.7
Summary
Enables transcription corepressor activity. Predicted to be involved in negative regulation of transcription, DNA-templated; nucleosome assembly; and regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and chromatin organization. Located in nucleus. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in islet cell tumor and ovary epithelial cancer. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7013053..7033667, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7095790..7114740, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene kinesin family member C1 Neighboring gene zinc finger and BTB domain containing 22b Neighboring gene TAP binding protein (tapasin), tandem duplicate 1 Neighboring gene major histocompatibility complex class I UKA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression analysis of an apoptosis-associated gene Daxx from zebrafish, Danio rerio. Qi L, et al. Fish Shellfish Immunol, 2015 Jul. PMID 25862973
  2. Characterization of the MHC class I region of the Japanese pufferfish (Fugu rubripes). Clark MS, et al. Immunogenetics, 2001. PMID 11220619
  3. Structure, linkage mapping and expression of the heart-type fatty acid-binding protein gene (fabp3 ) from zebrafish (Danio rerio). Liu RZ, et al. Eur J Biochem, 2003 Aug. PMID 12869198
  4. Identification of seven genes in the major histocompatibility complex class I region of the zebrafish. Sültmann H, et al. Scand J Immunol, 2000 Jun. PMID 10849368
  5. A contig map of the Mhc class I genomic region in the zebrafish reveals ancient synteny. Michalová V, et al. J Immunol, 2000 May 15. PMID 10799891

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
death domain-associated protein 6
Names
death-associated protein 6
fas-binding

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044949.1 → NP_001038414.1  death domain-associated protein 6

    See identical proteins and their annotated locations for NP_001038414.1

    Status: PROVISIONAL

    Source sequence(s)
    BX927188
    UniProtKB/TrEMBL
    A0A8M2B6B4, Q1LUU4
    Related
    ENSDARP00000105452.1, ENSDART00000123443.3
    Conserved Domains (2) summary
    cd13150
    Location:195 → 400
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:53 → 151
    Daxx; Daxx N-terminal Rassf1C-interacting domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    7013053..7033667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352251.2 → XP_017207740.1  death domain-associated protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWD7

  2. XM_005159438.4 → XP_005159495.2  death domain-associated protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B6F2
    Conserved Domains (2) summary
    cd13150
    Location:242 → 447
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:100 → 198
    Daxx; Daxx N-terminal Rassf1C-interacting domain

  3. XM_005159440.4 → XP_005159497.1  death domain-associated protein 6 isoform X3

    See identical proteins and their annotated locations for XP_005159497.1

    UniProtKB/TrEMBL
    A0A8M2B6B4, Q1LUU4
    Conserved Domains (2) summary
    cd13150
    Location:195 → 400
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:53 → 151
    Daxx; Daxx N-terminal Rassf1C-interacting domain
Nucleotide Protein Strain
Heading Accession and Version

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