yap1 Yes1 associated transcriptional regulator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: yap1provided by ZNC
Official Full Name: Yes1 associated transcriptional regulatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9710
See related: Ensembl:ENSDARG00000068401 AllianceGenome:ZFIN:ZDB-GENE-030131-9710
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zYAP; YAP65; cb194; sb:cb194; wu:fc18c04; zgc:158380; si:dkey-3b8.3; si:ch211-181p1.5
Summary: Involved in several processes, including dorsal/ventral axis specification; embryonic hemopoiesis; and heart formation. Acts upstream of with a positive effect on BMP signaling pathway. Acts upstream of or within several processes, including animal organ development; fin regeneration; and positive regulation of glutamate-ammonia ligase activity. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; mesoderm; and tail bud. Used to study coloboma. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (37283765..37355680, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (37302757..37374684, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPARalpha activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish.
Title: PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish.
Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.
Title: Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.
Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes.
Title: Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes.
Findings provide a new mechanism of bone formation through the Hippo-Yap pathway, integrating Yap in the signalling cascade that governs osteoprogenitor maintenance and subsequent differentiation during zebrafish caudal fin regeneration.
Title: Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration.
Despite its divergent transactivation domain, Yap1b cooperates with Yap1 to regulate cell survival and tissue morphogenesis during early development.
Title: yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets.
Yap deletion has minimal effect on myocyte proliferation in adults, but significantly influences scar formation and immune cell infiltration during zebrafish heart regeneration.
Title: Yap is required for scar formation but not myocyte proliferation during heart regeneration in zebrafish.
Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate zebrafish outflow tract valve morphogenesis.
Title: Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis.
Study in zebrafish fluorescent transgenic reporter lines of Yap1/Taz provided an in vivo view of Yap1/Taz activity during development and adulthood at the whole organism level. Analysis of vascular development in yap1/taz zebrafish mutants revealed specific defects in posterior cardinal vein formation, with altered expression of arterial/venous markers.
Title: Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development.
Transcriptomic and metabolomic analyses reveal that Yap regulates expression of glucose transporter glut1, causing decreased glucose uptake and use for nucleotide biosynthesis in yap (-/-) mutants, and impaired glucose tolerance in adults.
Title: Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.
Disrupted gene function in yap1(-/-); taz(+/-) embryos did not disturb liver bud formation, but instead impaired cell proliferation in liver and movement of the neighboring lateral plate mesoderm (LPM). Overexpression of wild type yap1 or taz could rescue the defective liver phenotypes in yap1(-/-); taz(+/-) embryos.
Title: Yap1/Taz are essential for the liver development in zebrafish.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

fc73b06.y1 (e-PCR)
- UniSTS:194383

fc18c04.x1 (e-PCR)
- UniSTS:187780

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Kupffer's vesicle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibronectin fibril organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of fibronectin fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventriculo bulbo valve development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcriptional coactivator YAP1

Names: Yes-associated protein 1; protein yorkie homolog; yap; yes-associated protein YAP65 homolog; yorkie homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001139480.1 → NP_001132952.1 transcriptional coactivator YAP1

See identical proteins and their annotated locations for NP_001132952.1

Status: PROVISIONAL

Source sequence(s)

AL954841

UniProtKB/Swiss-Prot

A1L1U5, Q1L8J7

Related

ENSDARP00000089684.4, ENSDART00000098914.5

Conserved Domains (3) summary

smart00456
Location:127 → 158

WW; Domain with 2 conserved Trp (W) residues

pfam00397
Location:188 → 217

WW; WW domain

pfam15238
Location:41 → 186

FAM181; FAM181

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

37283765..37355680 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173662.4 → XP_005173719.1 transcriptional coactivator YAP1 isoform X1

UniProtKB/TrEMBL

A0A8M2BKX9

Conserved Domains (2) summary

smart00456
Location:127 → 158

WW; Domain with 2 conserved Trp (W) residues

pfam15238
Location:41 → 197

FAM181; FAM181