plcg2 phospholipase C, gamma 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plcg2provided by ZNC
Official Full Name: phospholipase C, gamma 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9532
See related: Ensembl:ENSDARG00000068763 AllianceGenome:ZFIN:ZDB-GENE-030131-9532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj85b03; sb:eu1064; wu:fj85b03; zgc:152893; si:ch211-260p9.2
Summary: Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within intracellular signal transduction and phospholipid catabolic process. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (13248956..13293642)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (13280444..13325130)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

NP_001038433.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044968.1 → NP_001038433.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Status: PROVISIONAL

Source sequence(s)

BX511124

UniProtKB/TrEMBL

A0A8M1N9W3, Q1LWV8

Related

ENSDARP00000075155.4, ENSDART00000080709.6

Conserved Domains (8) summary

cd00275
Location:1044 → 1169

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08628
Location:307 → 442

PI-PLCc_gamma2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma2

cd09932
Location:631 → 734

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:516 → 617

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cd11969
Location:762 → 816

SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2

cd13362
Location:22 → 139

PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain

cl14615
Location:892 → 1017

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

cl17171
Location:826 → 893

PH-like; Pleckstrin homology-like domain