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grb10b growth factor receptor-bound protein 10b [ Danio rerio (zebrafish) ]

Gene ID: 562032, updated on 27-Mar-2024

Summary

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Official Symbol
grb10bprovided by ZNC
Official Full Name
growth factor receptor-bound protein 10bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091020-12
See related
Ensembl:ENSDARG00000035308 AllianceGenome:ZFIN:ZDB-GENE-091020-12
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-149m3.3
Summary
Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See grb10b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (8364601..8520472, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (8453412..8606739, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 3 Neighboring gene dopa decarboxylase Neighboring gene cordon-bleu WH2 repeat protein Neighboring gene chemokine (C-C motif) receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    8364601..8520472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292073.3 → XP_009290348.1  growth factor receptor-bound protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B1G4, F1QSC3
    Related
    ENSDARP00000122780.2, ENSDART00000137365.3
    Conserved Domains (5) summary
    cd01787
    Location:164 → 245
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:487 → 594
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:285 → 407
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:290 → 398
    PH; PH domain
    pfam08947
    Location:425 → 469
    BPS; BPS (Between PH and SH2)

  2. XM_685427.7 → XP_690519.4  growth factor receptor-bound protein 10 isoform X1

    See identical proteins and their annotated locations for XP_690519.4

    UniProtKB/TrEMBL
    A0A8M9P869
    Conserved Domains (4) summary
    cd01787
    Location:165 → 246
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:488 → 595
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:286 → 408
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:426 → 470
    BPS; BPS (Between PH and SH2)

  3. XM_021466848.1 → XP_021322523.1  growth factor receptor-bound protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P869
    Conserved Domains (4) summary
    cd01787
    Location:165 → 246
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:488 → 595
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:286 → 408
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:426 → 470
    BPS; BPS (Between PH and SH2)

  4. XM_005157874.3 → XP_005157931.1  growth factor receptor-bound protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B462
    Conserved Domains (5) summary
    cd10415
    Location:337 → 444
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:135 → 257
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:140 → 248
    PH; PH domain
    pfam08947
    Location:275 → 319
    BPS; BPS (Between PH and SH2)
    cl00155
    Location:13 → 95
    UBQ; Ubiquitin-like proteins
Nucleotide Protein Strain
Heading Accession and Version

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