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socs2 suppressor of cytokine signaling 2 [ Danio rerio (zebrafish) ]

Gene ID: 562062, updated on 27-Mar-2024

Summary

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Official Symbol
socs2provided by ZNC
Official Full Name
suppressor of cytokine signaling 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-171
See related
Ensembl:ENSDARG00000045557 AllianceGenome:ZFIN:ZDB-GENE-041210-171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-202b22.1
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within intracellular signal transduction; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of cell growth. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See socs2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18431531..18436958, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18442748..18448229, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108183547 Neighboring gene CASP2 and RIPK1 domain containing adaptor with death domain Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene si:dkey-202b22.6 Neighboring gene synthesis of cytochrome C oxidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cortisol plays a role in the high environmental ammonia associated suppression of the immune response in zebrafish. Gonçalves AF, et al. Gen Comp Endocrinol, 2017 Aug 1. PMID 28263819
  2. Prolactin controls branchial clcn2c but not atp1a1a.2 in zebrafish Danio rerio. Breves JP. J Fish Biol, 2019 Jan. PMID 30367725
  3. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. Janjuha S, et al. Elife, 2018 Apr 6. PMID 29624168, Free PMC Article
  4. Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA. Banks KM, et al. Cell Rep, 2021 Jan 12. PMID 33440144, Free PMC Article
  5. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Shi C, et al. J Mol Cell Biol, 2020 May 18. PMID 31237951, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
suppressor of cytokine signaling 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114550.1 → NP_001108022.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001108022.1

    Status: PROVISIONAL

    Source sequence(s)
    EF195761
    UniProtKB/TrEMBL
    A0A8M2BBX4, B0EVP5, F1QHR7
    Related
    ENSDARP00000152969.1, ENSDART00000190271.1
    Conserved Domains (2) summary
    cd10383
    Location:36 → 138
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:157 → 197
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    18431531..18436958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164747.4 → XP_005164804.1  suppressor of cytokine signaling 2 isoform X1

    See identical proteins and their annotated locations for XP_005164804.1

    UniProtKB/TrEMBL
    A0A8M3ARE8
    Conserved Domains (2) summary
    cd03736
    Location:158 → 198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
    cl15255
    Location:36 → 139
    SH2; Src homology 2 (SH2) domain

  2. XM_005164748.4 → XP_005164805.1  suppressor of cytokine signaling 2 isoform X2

    See identical proteins and their annotated locations for XP_005164805.1

    UniProtKB/TrEMBL
    A0A8M2BBX4, B0EVP5, F1QHR7
    Related
    ENSDARP00000114987.2, ENSDART00000141671.3
    Conserved Domains (2) summary
    cd10383
    Location:36 → 138
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:157 → 197
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

  3. XM_009300289.3 → XP_009298564.1  suppressor of cytokine signaling 2 isoform X1

    See identical proteins and their annotated locations for XP_009298564.1

    UniProtKB/TrEMBL
    A0A8M3ARE8
    Conserved Domains (2) summary
    cd03736
    Location:158 → 198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
    cl15255
    Location:36 → 139
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version

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