bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmpr2aprovided by ZNC
Official Full Name: bone morphogenetic protein receptor, type II a (serine/threonine kinase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-070618-1
See related: Ensembl:ENSDARG00000011941 AllianceGenome:ZFIN:ZDB-GENE-070618-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables transforming growth factor beta-activated receptor activity. Acts upstream of or within BMP signaling pathway; embryonic organ morphogenesis; and vasculature development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood island; ovary; pronephric duct; tail bud; and trunk vasculature. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (12795383..12851740, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (12562088..12616486, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signaling through Bmpr2a receptor.
Title: Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signaling through Bmpr2a receptor.
bmpr2a mediates BMP signaling and is required to establish left-right asymmetry.
Title: Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasculature development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein receptor type-2a; bone morphogenetic protein receptor, type II a (serine/threonine kinase)

Names: bone morphogenetic protein receptor type II a; bone morphogenetic protein receptor type IIa

NP_001034906.1

EC 2.7.11.30

XP_005165892.1

EC 2.7.11.30

XP_009300509.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039817.1 → NP_001034906.1 bone morphogenetic protein receptor type-2a precursor

See identical proteins and their annotated locations for NP_001034906.1

Status: PROVISIONAL

Source sequence(s)

DQ002898

UniProtKB/TrEMBL

Q288P3

Related

ENSDARP00000056763.4, ENSDART00000056764.5

Conserved Domains (3) summary

smart00220
Location:209 → 499

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:212 → 508

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:64 → 134

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

12795383..12851740 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165835.4 → XP_005165892.1 bone morphogenetic protein receptor, type II a (serine/threonine kinase) isoform X1

UniProtKB/TrEMBL

A0A8M2BD77

Conserved Domains (3) summary

smart00220
Location:209 → 499

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:212 → 508

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:64 → 134

Activin_recp; Activin types I and II receptor domain
XM_009302234.3 → XP_009300509.1 bone morphogenetic protein receptor, type II a (serine/threonine kinase) isoform X2

UniProtKB/TrEMBL

A0A8M3AT76

Conserved Domains (1) summary

cl21453
Location:1 → 56

PKc_like; Protein Kinases, catalytic domain