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Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 [ Mus musculus (house mouse) ]

Gene ID: 56388, updated on 8-Feb-2024

Summary

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Official Symbol
Cyp3a25provided by MGI
Official Full Name
cytochrome P450, family 3, subfamily a, polypeptide 25provided by MGI
Primary source
MGI:MGI:1930638
See related
Ensembl:ENSMUSG00000029630 AllianceGenome:MGI:1930638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including caffeine oxidase activity; iron ion binding activity; and monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in cytoplasm. Is expressed in liver and lung. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to human CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 60.0), liver E18 (RPKM 11.2) and 3 other tissues See more
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Genomic context

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Location:
5 G2; 5 85.17 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145914002..145946454, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145977192..146009644, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38744 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 11 Neighboring gene STARR-seq mESC enhancer starr_14836 Neighboring gene STARR-seq mESC enhancer starr_14837 Neighboring gene STARR-seq mESC enhancer starr_14838 Neighboring gene predicted gene 8454 Neighboring gene STARR-seq mESC enhancer starr_14839 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase. Dai D, et al. J Biochem Mol Toxicol, 2001. PMID 11284050
  2. A map of the mouse Cyp3a locus. Zaphiropoulos PG. DNA Seq, 2003 Jun. PMID 14509827
  3. Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Creasy KT, et al. Gene Expr, 2016. PMID 27197076, Free PMC Article
  4. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Choudhary D, et al. Arch Biochem Biophys, 2003 Jun 1. PMID 12745259
  5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables estrogen 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables estrogen 2-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid 4-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 6-beta-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables testosterone 6-beta-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 3A25
Names
CYPIIIA25
cytochrome P450, 3a25
NP_062766.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019792.2 → NP_062766.2  cytochrome P450 3A25

    See identical proteins and their annotated locations for NP_062766.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AK149541, BY099368, Y11995
    Consensus CDS
    CCDS19866.1
    UniProtKB/Swiss-Prot
    O09158
    UniProtKB/TrEMBL
    Q9QXK4
    Related
    ENSMUSP00000065585.7, ENSMUST00000068317.13
    Conserved Domains (1) summary
    pfam00067
    Location:39 → 493
    p450; Cytochrome P450

RNA

  1. NR_030782.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the CDS, as compared to variant 1. The resulting transcript is a nonsense-mediated mRNA decay candidate, and is probably not making a protein.
    Source sequence(s)
    AK149541
    Related
    ENSMUST00000145062.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145914002..145946454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003955679.1 RNA Sequence

  2. XR_003955678.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09158.1 GenPept UniProtKB/Swiss-Prot:O09158

Gene LinkOut

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