U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PSG4 pregnancy specific beta-1-glycoprotein 4 [ Homo sapiens (human) ]

Gene ID: 5672, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PSG4provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 4provided by HGNC
Primary source
HGNC:HGNC:9521
See related
Ensembl:ENSG00000243137 MIM:176393; AllianceGenome:HGNC:9521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG9; PSBG-4; PSBG-9
Summary
The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Restricted expression toward placenta (RPKM 137.5) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PSG4 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43192702..43205638, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46013303..46026253, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43696854..43709790, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PSG11, PSG2 and PSG5 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 9 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 5 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:43754009-43754509 Neighboring gene pregnancy specific beta-1-glycoprotein 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pregnancy-specific glycoprotein gene expression and the induction by 5-bromo-2'-deoxyuridine. Pan CJ, et al. Biochemistry, 1994 Jun 14. PMID 8003489
  2. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. . Biochem Biophys Res Commun, 1990 May 16. PMID 2346490
  3. Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. Chan WY, et al. DNA, 1988 Oct. PMID 3180995
  4. Characterization of new members of the pregnancy-specific beta 1-glycoprotein family. Chan WY, et al. Mol Cell Biochem, 1991 Aug 14. PMID 1922019
  5. A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. Kimoto Y. Mol Gen Genet, 1998 May. PMID 9645429

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
pregnancy-specific beta-1-glycoprotein 4
Names
PS-beta-G-4
PS-beta-G-9
Pregnancy-specific beta-1-glycoprotein-4
pregnancy-specific beta-1-glycoprotein 9
pregnancy-specific glycoprotein 4
pregnancy-specific glycoprotein 9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276495.2 → NP_001263424.1  pregnancy-specific beta-1-glycoprotein 4 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC005392, AK075149, BC008405
    Consensus CDS
    CCDS62695.1
    UniProtKB/TrEMBL
    B3KQL2
    Related
    ENSP00000387864.2, ENST00000433626.6
    Conserved Domains (3) summary
    cd05740
    Location:148 → 236
    IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
    cd05774
    Location:36 → 138
    IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd20948
    Location:245 → 320
    IgC2_CEACAM5-like; Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains

  2. NM_001316339.2 → NP_001303268.1  pregnancy-specific beta-1-glycoprotein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC005392, BC008405, BC063127, DA837940, DA838139
    UniProtKB/TrEMBL
    M0R0B3
    Related
    ENSP00000471124.1, ENST00000596907.5
    Conserved Domains (3) summary
    smart00410
    Location:217 → 289
    IG_like; Immunoglobulin like
    pfam13895
    Location:213 → 291
    Ig_2; Immunoglobulin domain
    cl11960
    Location:119 → 207
    Ig; Immunoglobulin domain

  3. NM_002780.5 → NP_002771.2  pregnancy-specific beta-1-glycoprotein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002771.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005392, BC008405, BC013431
    Consensus CDS
    CCDS46093.1
    UniProtKB/Swiss-Prot
    E7EX79, Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76
    UniProtKB/TrEMBL
    Q6P520
    Related
    ENSP00000384770.3, ENST00000405312.8
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339 → 411
    IG_like; Immunoglobulin like
    pfam13895
    Location:335 → 413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:241 → 329
    Ig; Immunoglobulin domain

  4. NM_213633.3 → NP_998798.1  pregnancy-specific beta-1-glycoprotein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_998798.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC005392, BC008405, U18469
    Consensus CDS
    CCDS33039.1
    UniProtKB/Swiss-Prot
    Q00888
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000244295.8, ENST00000244295.13
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246 → 318
    IG_like; Immunoglobulin like
    pfam13895
    Location:242 → 320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43192702..43205638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439105.1 → XP_047295061.1  pregnancy-specific beta-1-glycoprotein 4 isoform X4

  2. XM_047439104.1 → XP_047295060.1  pregnancy-specific beta-1-glycoprotein 4 isoform X3

  3. XM_047439103.1 → XP_047295059.1  pregnancy-specific beta-1-glycoprotein 4 isoform X1

  4. XM_017026997.3 → XP_016882486.1  pregnancy-specific beta-1-glycoprotein 4 isoform X2

    UniProtKB/TrEMBL
    Q6P520

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46013303..46026253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321489.1 → XP_054177464.1  pregnancy-specific beta-1-glycoprotein 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00888.3 GenPept UniProtKB/Swiss-Prot:Q00888

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous