ripk1l receptor (TNFRSF)-interacting serine-threonine kinase 1, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ripk1lprovided by ZNC
Official Full Name: receptor (TNFRSF)-interacting serine-threonine kinase 1, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-132
See related: Ensembl:ENSDARG00000006677 AllianceGenome:ZFIN:ZDB-GENE-070705-132
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rip1; si:ch211-241e1.1
Summary: Predicted to enable JUN kinase kinase kinase activity. Predicted to act upstream of or within programmed cell death; protein phosphorylation; and signal transduction. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (904419..920580)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (1034011..1050172)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stage-specific expression of TNFalpha regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells.
Title: Stage-specific expression of TNFα regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to chemical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of response to external stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in regulation of metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to organic substance	IEA Inferred from Electronic Annotation more info
involved_in response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: receptor-interacting serine/threonine-protein kinase 1

Names: Ripk1; receptor-interacting 1

NP_001036815.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001043350.1 → NP_001036815.1 receptor-interacting serine/threonine-protein kinase 1

See identical proteins and their annotated locations for NP_001036815.1

Status: PROVISIONAL

Source sequence(s)

DQ848680

UniProtKB/TrEMBL

Q0MSH9

Related

ENSDARP00000014604.7, ENSDART00000024967.10

Conserved Domains (4) summary

smart00221
Location:15 → 284

STYKc; Protein kinase; unclassified specificity

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cd14027
Location:21 → 289

STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1

pfam12721
Location:484 → 534

RHIM; RIP homotypic interaction motif