pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3c2bprovided by ZNC
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050309-145
See related: Ensembl:ENSDARG00000086927 AllianceGenome:ZFIN:ZDB-GENE-050309-145
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7150469
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration; phosphatidylinositol 3-kinase signaling; and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including margin; mesoderm; nervous system; neural plate; and notochord. Orthologous to human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (23595387..23696766, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (23354121..23458896, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pik3c2b is a genetic modifier of Mtm1 mutation with a role in function and survival in myotubular myopathy animal models
Title: PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

fi33e03.x1 (e-PCR)
- UniSTS:197312

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Names: phosphoinositide-3-kinase, class 2, beta polypeptide

XP_003199535.1

EC 2.7.1.154

XP_009304289.1

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

23595387..23696766 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003199487.5 → XP_003199535.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

See identical proteins and their annotated locations for XP_003199535.1

UniProtKB/TrEMBL

A0A8M1RIX8, F1QWN6

Related

ENSDARP00000110942.2, ENSDART00000124810.4

Conserved Domains (6) summary

cd00895
Location:934 → 1287

PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta

cd04012
Location:569 → 741

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1458 → 1579

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:763 → 928

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl02484
Location:322 → 413

PI3K_rbd; PI3-kinase family, ras-binding domain

cl02563
Location:1317 → 1425

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_009306014.3 → XP_009304289.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

See identical proteins and their annotated locations for XP_009304289.1

UniProtKB/TrEMBL

A0A8M1RIX8, F1QWN6

Related

ENSDARP00000154070.1, ENSDART00000189599.1

Conserved Domains (6) summary

cd00895
Location:934 → 1287

PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta

cd04012
Location:569 → 741

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1458 → 1579

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:763 → 928

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl02484
Location:322 → 413

PI3K_rbd; PI3-kinase family, ras-binding domain

cl02563
Location:1317 → 1425

PX_domain; The Phox Homology domain, a phosphoinositide binding module