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map2k4b mitogen-activated protein kinase kinase 4b [ Danio rerio (zebrafish) ]

Gene ID: 568951, updated on 14-Apr-2024

Summary

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Official Symbol
map2k4bprovided by ZNC
Official Full Name
mitogen-activated protein kinase kinase 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080721-13
See related
Ensembl:ENSDARG00000077177 AllianceGenome:ZFIN:ZDB-GENE-080721-13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MKK4B; zgc:194486
Summary
Predicted to enable JUN kinase kinase activity. Acts upstream of or within convergent extension involved in gastrulation. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 12
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (280137..287821, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (83262..90270, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene myosin-16-like Neighboring gene growth arrest-specific 7b Neighboring gene uncharacterized LOC103910607 Neighboring gene growth arrest-specific protein 7-like Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Chou CM, et al. J Biomed Sci, 2015 Nov 17. PMID 26572230, Free PMC Article
  2. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Seo J, et al. J Cell Biochem, 2010 Jul 1. PMID 20564202
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within convergent extension involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4b
Names
MAP kinase kinase 4B
NP_001082890.1
XP_005173008.1
XP_021335830.1
XP_021335831.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089421.1 → NP_001082890.1  dual specificity mitogen-activated protein kinase kinase 4b

    See identical proteins and their annotated locations for NP_001082890.1

    Status: PROVISIONAL

    Source sequence(s)
    EF489398
    UniProtKB/TrEMBL
    A4UU31, D6RRB6
    Related
    ENSDARP00000101456.2, ENSDART00000113335.4
    Conserved Domains (2) summary
    smart00220
    Location:121 → 385
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:114 → 403
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    280137..287821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480156.1 → XP_021335831.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QIV0
    Conserved Domains (1) summary
    cd06616
    Location:179 → 476
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

  2. XM_021480155.1 → XP_021335830.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QMM1
    Conserved Domains (1) summary
    cd06616
    Location:190 → 487
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

  3. XM_005172951.4 → XP_005173008.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BK72
    Conserved Domains (2) summary
    smart00220
    Location:186 → 450
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:179 → 468
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
Nucleotide Protein
Heading Accession and Version

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