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NMUR2 neuromedin U receptor 2 [ Homo sapiens (human) ]

Gene ID: 56923, updated on 11-Apr-2024

Summary

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Official Symbol
NMUR2provided by HGNC
Official Full Name
neuromedin U receptor 2provided by HGNC
Primary source
HGNC:HGNC:16454
See related
Ensembl:ENSG00000132911 MIM:605108; AllianceGenome:HGNC:16454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FM4; FM-4; TGR1; NMU2R; TGR-1; NMU-R2
Summary
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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Location:
5q33.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (152391546..152405279, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (152924513..152938245, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (151771107..151784840, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378236 Neighboring gene uncharacterized LOC105378237 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:151724791-151725393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16530 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82574 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82576 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82586 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82589 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82596 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82611 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82644 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82645 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82651 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82653 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82661 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82666 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82670/82671 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82672 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82684 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_82696 and experimental_82697 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_82718 and experimental_82721/82722 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82727 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82735 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82741 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82746 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82750 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82779 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82809 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23469 Neighboring gene ribosomal protein L36a pseudogene 20 Neighboring gene NANOG hESC enhancer GRCh37_chr5:151891040-151891644 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83006 Neighboring gene tRNA-Cys (anticodon ACA) 1-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD. Do AR, et al. Sci Rep, 2022 Dec 21. PMID 36543808, Free PMC Article
  2. Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor. Alhosaini K, et al. Mol Pharmacol, 2018 Jul. PMID 29724789
  3. Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro. Lin TY, et al. PLoS One, 2015. PMID 26317338, Free PMC Article
  4. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. Bhattacharyya S, et al. J Endocrinol, 2004 Oct. PMID 15525579
  5. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. Shan L, et al. J Biol Chem, 2000 Dec 15. PMID 11010960

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.
    Title: A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.
  2. Activation by NMU2 is longer lasting if NmS is the ligand.
    Title: Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor.
  3. NMU might contribute to progression of NMUR2-positive breast cancer
    Title: Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.
  4. polymorphisms in the gene may be useful in identifying women at risk for osteoporosis.
    Title: Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.
  5. Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 and NMUR2 without Neuromedin U (NMU). Its expression can block NMU signaling suppressing then ovarian cancer cells proliferation.
    Title: Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro.
  6. A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist.
    Title: Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
EBI GWAS Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuromedin U binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuromedin U receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in feeding behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in grooming behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in reduction of food intake in response to dietary excess IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of smooth muscle contraction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to pain IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
neuromedin-U receptor 2
Names
G-protein coupled receptor FM-4
G-protein coupled receptor TGR-1
growth hormone secretagogue receptor family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020167.5 → NP_064552.3  neuromedin-U receptor 2

    See identical proteins and their annotated locations for NP_064552.3

    Status: REVIEWED

    Source sequence(s)
    AC008571, AI023570, BC067776
    Consensus CDS
    CCDS4321.1
    UniProtKB/Swiss-Prot
    Q7LC54, Q96AM5, Q9GZQ4, Q9NRA6
    Related
    ENSP00000255262.4, ENST00000255262.4
    Conserved Domains (2) summary
    cd15357
    Location:46 → 338
    7tmA_NMU-R2; neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam19285
    Location:331 → 397
    NmU-R2_C_term; Neuromedin-U receptor 2, C-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    152391546..152405279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    152924513..152938245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZQ4.2 GenPept UniProtKB/Swiss-Prot:Q9GZQ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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