adcy1b adenylate cyclase 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adcy1bprovided by ZNC
Official Full Name: adenylate cyclase 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-100805-1
See related: Ensembl:ENSDARG00000088634 AllianceGenome:ZFIN:ZDB-GENE-100805-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable adenylate cyclase activity. Acts upstream of or within axon midline choice point recognition; retinal ganglion cell axon guidance; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (136346..162810, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (147297..175357, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G39519 (e-PCR)
- UniSTS:16175

G46011 (e-PCR)
- UniSTS:106813

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon midline choice point recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate cyclase type 1b

NP_001161822.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168350.1 → NP_001161822.1 adenylate cyclase type 1b

See identical proteins and their annotated locations for NP_001161822.1

Status: PROVISIONAL

Source sequence(s)

GU169395

UniProtKB/TrEMBL

D1MIA3

Related

ENSDARP00000107181.1, ENSDART00000131177.3

Conserved Domains (4) summary

smart00044
Location:236 → 431

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:839 → 1035

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:498 → 585

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:128 → 270

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region