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OTUD7B OTU deubiquitinase 7B [ Homo sapiens (human) ]

Gene ID: 56957, updated on 17-Mar-2024

Summary

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Official Symbol
OTUD7Bprovided by HGNC
Official Full Name
OTU deubiquitinase 7Bprovided by HGNC
Primary source
HGNC:HGNC:16683
See related
Ensembl:ENSG00000264522 MIM:611748; AllianceGenome:HGNC:16683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZA20D1; CEZANNE
Summary
Enables Lys48-specific deubiquitinase activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

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See OTUD7B in Genome Data Viewer
Location:
1q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149937812..150067653, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149062296..149192273, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149909705..149982675, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149908038-149908562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1667 Neighboring gene splicing factor 3b subunit 4 Neighboring gene myotubularin related protein 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149981420-149982302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1292 Neighboring gene uncharacterized LOC124904413 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:149989091-149989750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149989751-149990408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1669 Neighboring gene ribosomal protein L6 pseudogene 31 Neighboring gene vacuolar protein sorting 45 homolog Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150122046-150122546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150131051-150131552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1673 Neighboring gene pleckstrin homology domain containing O1 Neighboring gene long intergenic non-protein coding RNA 2988 Neighboring gene Sharpr-MPRA regulatory region 9169

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma. Wang JH, et al. J Transl Med, 2015 Feb 1. PMID 25638165, Free PMC Article
  2. [Expression of zinc finger protein A20 in pediatric inflammatory bowel disease]. Zheng CF, et al. Zhonghua Er Ke Za Zhi, 2011 Apr. PMID 21624200
  3. OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation. Tang J, et al. Cell Death Dis, 2021 May 25. PMID 34035221, Free PMC Article
  4. Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling. An W, et al. Cardiovasc Res, 2022 Jan 29. PMID 33599243, Free PMC Article
  5. Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R. Chen X, et al. Am J Cancer Res, 2020. PMID 33415003, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OTU deubiquitinase 7B facilitates the hyperthermia-induced inhibition of lung cancer progression through enhancing Smac-mediated mitochondrial dysfunction.
    Title: OTU deubiquitinase 7B facilitates the hyperthermia-induced inhibition of lung cancer progression through enhancing Smac-mediated mitochondrial dysfunction.
  2. OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession.
    Title: OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession.
  3. The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
    Title: The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
  4. Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling.
    Title: Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.
  5. OTUD7B stabilizes estrogen receptor alpha and promotes breast cancer cell proliferation.
    Title: OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation.
  6. Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding.
    Title: Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding.
  7. The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137. Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway.
    Title: Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway.
  8. Cezanne serves as a "reader" of the Lys63-linkage polyubiquitin at DNA damage sites and an "eraser" of the Lys11-linkage ubiquitination, indicating a crosstalk between linkage-specific ubiquitination at DNA damage sites
    Title: Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.
  9. Cezanne binds established APC/C substrates and reverses their APC/C-mediated ubiquitination. Cezanne depletion accelerates APC/C substrate degradation and causes errors in mitotic progression and formation of micronuclei.
    Title: Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates.
  10. Study demonstrated that the N-terminal UBA domain is crucial for the function of Cezanne during NF-kappaB activation. Cezanne is recognized and recruited into activated TNFR complex by specifically binding to polyubiquitinated signaling proteins after TNF stimulation through its N-terminal polyubiquitin binding site.
    Title: The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables K48-linked deubiquitinase activity TAS
Traceable Author Statement
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
OTU domain-containing protein 7B
Names
OTU domain containing 7B
cellular zinc finger anti-NF-kappa-B protein
cellular zinc finger anti-NF-kappaB Cezanne
zinc finger A20 domain-containing protein 1
zinc finger protein Cezanne
zinc finger, A20 domain containing 1
NP_064590.2
XP_011508084.1
XP_011508086.1
XP_011508087.1
XP_011508090.1
XP_016857339.1
XP_047281668.1
XP_047281671.1
XP_047281672.1
XP_047281673.1
XP_047281676.1
XP_047281677.1
XP_054193734.1
XP_054193735.1
XP_054193736.1
XP_054193737.1
XP_054193738.1
XP_054193739.1
XP_054193740.1
XP_054193741.1
XP_054193742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020205.4 → NP_064590.2  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_064590.2

    Status: VALIDATED

    Source sequence(s)
    AC244033, BC015719, BC072681, BP321045, T51077
    Consensus CDS
    CCDS72903.1
    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
    Related
    ENSP00000462729.1, ENST00000581312.6
    Conserved Domains (4) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam07271
    Location:667 → 797
    Cytadhesin_P30; Cytadhesin P30/P32
    pfam01754
    Location:801 → 823
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149937812..150067653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425721.1 → XP_047281677.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

  2. XM_047425716.1 → XP_047281672.1  OTU domain-containing protein 7B isoform X1

  3. XM_047425712.1 → XP_047281668.1  OTU domain-containing protein 7B isoform X1

  4. XM_047425720.1 → XP_047281676.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

  5. XM_011509784.4 → XP_011508086.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508086.1

    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810 → 832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  6. XM_011509782.2 → XP_011508084.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508084.1

    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810 → 832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  7. XM_047425715.1 → XP_047281671.1  OTU domain-containing protein 7B isoform X1

  8. XM_047425717.1 → XP_047281673.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

  9. XM_011509785.3 → XP_011508087.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508087.1

    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810 → 832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  10. XM_017001850.2 → XP_016857339.1  OTU domain-containing protein 7B isoform X4

  11. XM_011509788.3 → XP_011508090.1  OTU domain-containing protein 7B isoform X3

    See identical proteins and their annotated locations for XP_011508090.1

    Conserved Domains (2) summary
    pfam01754
    Location:731 → 753
    zf-A20; A20-like zinc finger
    cl19932
    Location:110 → 280
    OTU; OTU-like cysteine protease

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149062296..149192273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337764.1 → XP_054193739.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

  2. XM_054337760.1 → XP_054193735.1  OTU domain-containing protein 7B isoform X1

  3. XM_054337761.1 → XP_054193736.1  OTU domain-containing protein 7B isoform X1

  4. XM_054337763.1 → XP_054193738.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

  5. XM_054337759.1 → XP_054193734.1  OTU domain-containing protein 7B isoform X1

  6. XM_054337762.1 → XP_054193737.1  OTU domain-containing protein 7B isoform X1

  7. XM_054337765.1 → XP_054193740.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

  8. XM_054337767.1 → XP_054193742.1  OTU domain-containing protein 7B isoform X4

  9. XM_054337766.1 → XP_054193741.1  OTU domain-containing protein 7B isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GQQ9.1 GenPept UniProtKB/Swiss-Prot:Q6GQQ9

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