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AGTRAP angiotensin II receptor associated protein [ Homo sapiens (human) ]

Gene ID: 57085, updated on 3-Apr-2024

Summary

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Official Symbol
AGTRAPprovided by HGNC
Official Full Name
angiotensin II receptor associated proteinprovided by HGNC
Primary source
HGNC:HGNC:13539
See related
Ensembl:ENSG00000177674 MIM:608729; AllianceGenome:HGNC:13539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATRAP
Summary
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 38.0), prostate (RPKM 28.1) and 25 other tissues See more
Orthologs
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Genomic context

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See AGTRAP in Genome Data Viewer
Location:
1p36.22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11736136..11750769)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11280231..11294863)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11796193..11810826)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 170 Neighboring gene F-box protein 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11743170-11743751 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11744701-11745201 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750065-11750574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750575-11751082 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11764337-11764964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11786269-11787256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808242-11808918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808919-11809595 Neighboring gene atrophin-1-like Neighboring gene chromosome 1 open reading frame 167 Neighboring gene C1orf167 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population. Ali Z, et al. Acta Med Indones, 2018 Oct. PMID 30630996
  2. A role for AT1 receptor-associated proteins in blood pressure regulation. Castrop H. Curr Opin Pharmacol, 2015 Apr. PMID 25562590
  3. Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock. Nakada TA, et al. Crit Care Med, 2011 Jul. PMID 21423001
  4. Influence of endogenous angiotensin II on control of sympathetic nerve activity in human dehydration. Rabbitts JA, et al. J Physiol, 2009 Nov 15. PMID 19805740, Free PMC Article
  5. The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019. Wakui H. Clin Exp Nephrol, 2020 Apr. PMID 32112267, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling.
    Title: USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling.
  2. S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
    Title: S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
  3. The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019.
    Title: The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019.
  4. Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line.
    Title: Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line.
  5. Leukocyte ATRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of non-communicable diseases.
    Title: Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile.
  6. There was positive association between A1166C AT1R polymorphism and susceptibility of type-2 diabetics to diabetic nephropathy (DN) in the Malay Indonesian population.
    Title: Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population.
  7. A role for AT1 receptor-associated proteins in blood pressure regulation
    Title: A role for AT1 receptor-associated proteins in blood pressure regulation.
  8. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function.
    Title: Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity.
  9. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
    Title: The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
  10. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
    Title: Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29646

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables angiotensin type II receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
type-1 angiotensin II receptor-associated protein
Names
AT1 receptor-associated protein
ATI receptor-associated protein
angiotensin II, type I receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040194.2 → NP_001035284.1  type-1 angiotensin II receptor-associated protein isoform b

    See identical proteins and their annotated locations for NP_001035284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BI117521, BQ672962
    Consensus CDS
    CCDS30585.1
    UniProtKB/TrEMBL
    A8K1X7
    Related
    ENSP00000365816.4, ENST00000376629.8
    Conserved Domains (1) summary
    pfam06396
    Location:9 → 145
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

  2. NM_001040195.2 → NP_001035285.1  type-1 angiotensin II receptor-associated protein isoform c

    See identical proteins and their annotated locations for NP_001035285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform c) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BQ672962, CA866314
    Consensus CDS
    CCDS30586.1
    UniProtKB/Swiss-Prot
    Q6RW13
    Related
    ENSP00000365824.3, ENST00000376637.7

  3. NM_001040196.2 → NP_001035286.1  type-1 angiotensin II receptor-associated protein isoform d

    See identical proteins and their annotated locations for NP_001035286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform d) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BE782705, BI117521, BQ672962
    Consensus CDS
    CCDS44056.1
    UniProtKB/TrEMBL
    X6R9H3
    Related
    ENSP00000408505.2, ENST00000452018.6
    Conserved Domains (1) summary
    cl05741
    Location:1 → 20
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

  4. NM_001040197.2 → NP_001035287.1  type-1 angiotensin II receptor-associated protein isoform e

    See identical proteins and their annotated locations for NP_001035287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform e) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BE782705, BI117521, BQ672962, CD674964
    Consensus CDS
    CCDS41248.1
    UniProtKB/TrEMBL
    X6R9H3
    Related
    ENSP00000383688.2, ENST00000400895.6
    Conserved Domains (1) summary
    cl05741
    Location:1 → 20
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

  5. NM_020350.5 → NP_065083.3  type-1 angiotensin II receptor-associated protein isoform a

    See identical proteins and their annotated locations for NP_065083.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the most common transcript and encodes isoform a.
    Source sequence(s)
    AF312374, AI741916, BC017328, BI117521, BQ672962
    Consensus CDS
    CCDS136.1
    UniProtKB/Swiss-Prot
    A8MVQ5, Q5SNV4, Q5SNV5, Q6RW13, Q96AC0, Q96PL4, Q9NRW9
    UniProtKB/TrEMBL
    A8K1X7
    Related
    ENSP00000319713.5, ENST00000314340.10
    Conserved Domains (1) summary
    pfam06396
    Location:9 → 152
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11736136..11750769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541802.3 → XP_011540104.1  type-1 angiotensin II receptor-associated protein isoform X2

    UniProtKB/TrEMBL
    X6R9H3
    Related
    ENSP00000365814.1, ENST00000376627.6

  2. XM_011541800.4 → XP_011540102.1  type-1 angiotensin II receptor-associated protein isoform X1

    UniProtKB/TrEMBL
    A8K1X7
    Conserved Domains (1) summary
    pfam06396
    Location:22 → 164
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

  3. XM_011541799.4 → XP_011540101.2  type-1 angiotensin II receptor-associated protein isoform X3

    UniProtKB/TrEMBL
    A8K1X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    11280231..11294863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337784.1 → XP_054193759.1  type-1 angiotensin II receptor-associated protein isoform X2

  2. XM_054337783.1 → XP_054193758.1  type-1 angiotensin II receptor-associated protein isoform X1

  3. XM_054337785.1 → XP_054193760.1  type-1 angiotensin II receptor-associated protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RW13.1 GenPept UniProtKB/Swiss-Prot:Q6RW13

Gene LinkOut

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