chrm3a cholinergic receptor, muscarinic 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chrm3aprovided by ZNC
Official Full Name: cholinergic receptor, muscarinic 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090410-4
See related: Ensembl:ENSDARG00000071091 AllianceGenome:ZFIN:ZDB-GENE-090410-4
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: chrm3
Summary: Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within cardiac conduction system development. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in eye. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (19831800..19963686, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (19811902..19943828, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled acetylcholine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled acetylcholine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled acetylcholine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac conduction system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within saliva secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, cholinergic	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: muscarinic acetylcholine receptor M3

Names: DrM3A; muscarinic cholinergic receptor 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

19831800..19963686 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_695289.9 → XP_700381.4 muscarinic acetylcholine receptor M3

See identical proteins and their annotated locations for XP_700381.4

UniProtKB/TrEMBL

A0A8M9PNY8, X1WHZ7

Related

ENSDARP00000129862.1, ENSDART00000154251.2

Conserved Domains (2) summary

cd14964
Location:71 → 95

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:66 → 258

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394980.1 Reference GRCz11 ALT_DRER_TU_1

Range

123752..252953 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473088.1 → XP_021328763.1 muscarinic acetylcholine receptor M3

UniProtKB/TrEMBL

A0A8M9PNY8, X1WHZ7

Conserved Domains (2) summary

cd14964
Location:71 → 95

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:66 → 258

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily