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PTAFR platelet activating factor receptor [ Homo sapiens (human) ]

Gene ID: 5724, updated on 4-Jan-2025

Summary

Official Symbol
PTAFRprovided by HGNC
Official Full Name
platelet activating factor receptorprovided by HGNC
Primary source
HGNC:HGNC:9582
See related
Ensembl:ENSG00000169403 MIM:173393; AllianceGenome:HGNC:9582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAFR
Summary
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in appendix (RPKM 15.7), bone marrow (RPKM 12.4) and 19 other tissues See more
Orthologs
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Genomic context

See PTAFR in Genome Data Viewer
Location:
1p35.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28147166..28193856, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27988997..28035686, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28473677..28520367, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 534 Neighboring gene RNA, U6 small nuclear 176, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28474708-28475208 Neighboring gene RNA, U7 small nuclear 29 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 535 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28559230-28559763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28561534-28562040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 591 Neighboring gene ATP synthase inhibitory factor subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Pre-incubation of podocytes with two platelet-activating factor (PAF) receptor antagonists prevents the loss and redistribution of nephrin induced by Tat, suggesting that PAF is an intracellular mediator of Tat action PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Potential readthrough

Included gene: DNAJC8

Gene Ontology Provided by GOA

Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
involved_in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  
involved_in cellular response to cAMP  
involved_in cellular response to fatty acid  
involved_in cellular response to gravity  
involved_in chemotaxis  
involved_in immune response PubMed 
involved_in inflammatory response  
involved_in inositol trisphosphate biosynthetic process  
involved_in lipopolysaccharide-mediated signaling pathway  
involved_in negative regulation of blood pressure  
involved_in parturition  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in positive regulation of cellular extravasation  
involved_in positive regulation of gastro-intestinal system smooth muscle contraction  
involved_in positive regulation of inositol phosphate biosynthetic process  
involved_in positive regulation of interleukin-6 production  
involved_in positive regulation of leukocyte tethering or rolling  
involved_in positive regulation of maternal process involved in parturition  
involved_in positive regulation of neutrophil degranulation  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of transcytosis  
involved_in positive regulation of translation  
involved_in positive regulation of tumor necrosis factor production  
involved_in regulation of transcription by RNA polymerase II  
involved_in response to dexamethasone  
involved_in response to symbiotic bacterium  
involved_in transcytosis  
Items 1 - 25 of 29
Component Evidence Code Pubs
located_in membrane PubMed 
located_in plasma membrane  
located_in secretory granule membrane  
located_in tertiary granule membrane  

General protein information

Preferred Names
platelet-activating factor receptor
Names
PAF-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029815.1 RefSeqGene

    Range
    22247..51771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000952.5NP_000943.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_000943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon, but has an alternate 5' segment, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, BC063000, DA923972
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Related
    ENSP00000362965.3, ENST00000373857.8
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001164721.2NP_001158193.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is composed of three exons. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, BC063000, DA705644
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Related
    ENSP00000442658.1, ENST00000539896.1
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001164722.3NP_001158194.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, DA705644
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Related
    ENSP00000301974.3, ENST00000305392.3
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001164723.3NP_001158195.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' exon, but has an additional exon in the 5' region, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, AL353354, CD013879
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    28147166..28193856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    27988997..28035686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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