U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTAFR platelet activating factor receptor [ Homo sapiens (human) ]

Gene ID: 5724, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PTAFRprovided by HGNC
Official Full Name
platelet activating factor receptorprovided by HGNC
Primary source
HGNC:HGNC:9582
See related
Ensembl:ENSG00000169403 MIM:173393; AllianceGenome:HGNC:9582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAFR
Summary
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in appendix (RPKM 15.7), bone marrow (RPKM 12.4) and 19 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p35.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28147166..28193856, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27988997..28035686, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28473677..28520367, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 534 Neighboring gene RNA, U6 small nuclear 176, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28474708-28475208 Neighboring gene RNA, U7 small nuclear 29 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 535 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28559230-28559763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28561534-28562040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 591 Neighboring gene ATP synthase inhibitory factor subunit 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Platelet-Activating Factor Receptor's Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine. Deuster E, et al. Cells, 2021 Sep 7. PMID 34571986, Free PMC Article
  2. PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis. Midgley A, et al. Immunobiology, 2021 Jan. PMID 33278709
  3. Particulate matter exposure promotes Pseudomonas aeruginosa invasion into airway epithelia by upregulating PAFR via the ROS-mediated PI3K pathway. Liu J, et al. Hum Cell, 2020 Oct. PMID 32627147
  4. Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Cao C, et al. Nat Struct Mol Biol, 2018 Jun. PMID 29808000
  5. Association of platelet-activating factor receptor gene rs5938 (G/T) and rs313152 (T/C) polymorphisms with coronary heart disease and blood stasis syndrome in a Chinese Han population. Zheng GH, et al. Chin J Integr Med, 2017 Dec. PMID 28197937

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis.
    Title: PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis.
  2. The Platelet-Activating Factor Receptor's Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine.
    Title: The Platelet-Activating Factor Receptor's Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine.
  3. Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor.
    Title: Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor.
  4. Particulate matter exposure promotes Pseudomonas aeruginosa invasion into airway epithelia by upregulating PAFR via the ROS-mediated PI3K pathway.
    Title: Particulate matter exposure promotes Pseudomonas aeruginosa invasion into airway epithelia by upregulating PAFR via the ROS-mediated PI3K pathway.
  5. The PAF Receptor (PAFR) structures, combined with single-molecule FRET and cell-based functional assays, suggest that the conformational change in the helical bundle is ligand dependent and plays a critical role in PAFR activation, thus greatly extending knowledge about signaling by G-protein-coupled receptors
    Title: Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
  6. he PAFR gene rs5938 or rs313152 polymorphisms might be a potential biomarker for susceptibility to coronary heart disease.
    Title: Association of platelet-activating factor receptor gene rs5938 (G/T) and rs313152 (T/C) polymorphisms with coronary heart disease and blood stasis syndrome in a Chinese Han population.
  7. Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival.
    Title: Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer.
  8. we demonstrate that PAFR inhibition can selectively enhances the sensitivity of radiotherapy in prostate cancer cells with elevated PAFR expression after irradiation exposure
    Title: PAFR selectively mediates radioresistance and irradiation-induced autophagy suppression in prostate cancer cells.
  9. PAFR overexpression is associated with pneumococcal infection.
    Title: Pneumococcal infection of respiratory cells exposed to welding fumes; Role of oxidative stress and HIF-1 alpha.
  10. WEB-2086 represents an innovative class of candidate drugs for inhibiting PAFr-dependent lung infections caused by the main bacterial drivers of smoking-related COPD.
    Title: An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat Pre-incubation of podocytes with two platelet-activating factor (PAF) receptor antagonists prevents the loss and redistribution of nephrin induced by Tat, suggesting that PAF is an intracellular mediator of Tat action PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: DNAJC8

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
  
enables lipopolysaccharide immune receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables platelet activating factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to gravity IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in inositol trisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in parturition IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cellular extravasation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gastro-intestinal system smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neutrophil degranulation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in response to dexamethasone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to symbiotic bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in transcytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
platelet-activating factor receptor
Names
PAF-R

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029815.1 RefSeqGene

    Range
    22247..51771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000952.5 → NP_000943.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_000943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon, but has an alternate 5' segment, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, BC063000, DA923972
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Related
    ENSP00000362965.3, ENST00000373857.8
    Conserved Domains (1) summary
    cd15147
    Location:16 → 304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001164721.2 → NP_001158193.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is composed of three exons. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, BC063000, DA705644
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Related
    ENSP00000442658.1, ENST00000539896.1
    Conserved Domains (1) summary
    cd15147
    Location:16 → 304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001164722.3 → NP_001158194.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, DA705644
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Related
    ENSP00000301974.3, ENST00000305392.3
    Conserved Domains (1) summary
    cd15147
    Location:16 → 304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001164723.3 → NP_001158195.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' exon, but has an additional exon in the 5' region, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, AL353354, CD013879
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    A3KMC8, A8K2H5, P25105
    UniProtKB/TrEMBL
    A8K7N8, B2R7Z4
    Conserved Domains (1) summary
    cd15147
    Location:16 → 304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    28147166..28193856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    27988997..28035686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25105.1 GenPept UniProtKB/Swiss-Prot:P25105

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous