Gstm3 glutathione S-transferase mu 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gstm3provided by RGD
Full Name: glutathione S-transferase mu 3provided by RGD
Primary source: RGD:620381
See related: Ensembl:ENSRNOG00000019058 AllianceGenome:RGD:620381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gstm4; GstYb4; Gstm3l; Gstm3l1
Summary: Predicted to enable glutathione transferase activity and identical protein binding activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytosol and intercellular bridge. Orthologous to human GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 149.2), Testes (RPKM 106.0) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198295442..198300742, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195590450..195612578, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210761729..210766501, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase Mu 3

Names: glutathione S-transferase M3; glutathione S-transferase M4; glutathione S-transferase Yb4; glutathione S-transferase mu 3-like 1

NP_065415.2

EC 2.5.1.18

XP_038958931.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020540.2 → NP_065415.2 glutathione S-transferase Mu 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HUW7, D3ZVQ8

Related

ENSRNOP00000044720.6, ENSRNOT00000051261.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198295442..198300742 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103003.2 → XP_038958931.1 glutathione S-transferase Mu 3 isoform X1

Conserved Domains (1) summary

cl02776
Location:13 → 104

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family