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GRAMD1B GRAM domain containing 1B [ Homo sapiens (human) ]

Gene ID: 57476, updated on 3-Apr-2024

Summary

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Official Symbol
GRAMD1Bprovided by HGNC
Official Full Name
GRAM domain containing 1Bprovided by HGNC
Primary source
HGNC:HGNC:29214
See related
Ensembl:ENSG00000023171 MIM:620179; AllianceGenome:HGNC:29214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC01059
Summary
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol and cholesterol homeostasis. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 12.4), duodenum (RPKM 5.7) and 11 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q24.1
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123358422..123627767)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123386861..123656743)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (123229130..123498475)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4014 Neighboring gene PHB1 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5678 Neighboring gene Sharpr-MPRA regulatory region 995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5681 Neighboring gene NANOG hESC enhancer GRCh37_chr11:123275922-123276438 Neighboring gene microRNA 4493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:123278189-123279097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5683 Neighboring gene uncharacterized LOC124902776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4016 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:123313949-123314928 Neighboring gene Sharpr-MPRA regulatory region 13459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5686 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123364173-123364689 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123364690-123365206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4018 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:123407917-123408491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123430192-123430855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123430856-123431518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123431519-123432182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123446989-123447488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123446487-123446988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123448087-123448624 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:123449825-123450047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123450909-123451518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123474209-123474708 Neighboring gene splicing factor 3a, subunit 3 pseudogene 2 Neighboring gene uncharacterized LOC124902777 Neighboring gene uncharacterized LOC105369543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4021 Neighboring gene sodium voltage-gated channel beta subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aster proteins mediate carotenoid transport in mammalian cells. Bandara S, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35394870, Free PMC Article
  2. Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b. Ercan B, et al. EMBO J, 2021 Mar 15. PMID 33604931, Free PMC Article
  3. GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling. Khanna P, et al. Sci Rep, 2018 Jun 22. PMID 29934528, Free PMC Article
  4. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport. Andersen JP, et al. Mol Metab, 2020 Dec. PMID 32738348, Free PMC Article
  5. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Conde L, et al. Nat Genet, 2010 Aug. PMID 20639881, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aster proteins mediate carotenoid transport in mammalian cells.
    Title: Aster proteins mediate carotenoid transport in mammalian cells.
  2. Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.
    Title: Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.
  3. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport.
    Title: Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport.
  4. Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression.
    Title: Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression.
  5. GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling
    Title: GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1201, MGC125622, MGC125623, MGC125625, AP000783.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to cholesterol ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum-plasma membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-plasma membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Aster-B
Names
Aster-B
GRAM domain-containing protein 1B
long intergenic non-protein coding RNA 1059

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286563.3 → NP_001273492.1  protein Aster-B isoform 1

    See identical proteins and their annotated locations for NP_001273492.1

    Status: VALIDATED

    Source sequence(s)
    AK127457, AP000841, AP002765, BC107480
    Consensus CDS
    CCDS66253.1
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Related
    ENSP00000402457.2, ENST00000456860.6
    Conserved Domains (2) summary
    cd13220
    Location:114 → 207
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:382 → 530
    DUF4782; Domain of unknown function (DUF4782)

  2. NM_001286564.3 → NP_001273493.1  protein Aster-B isoform 3

    See identical proteins and their annotated locations for NP_001273493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 18 and 19, encodes isoform 3.
    Source sequence(s)
    AB033027, AK297606, AP002765
    Consensus CDS
    CCDS66254.1
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Related
    ENSP00000432987.1, ENST00000529432.5
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  3. NM_001330396.3 → NP_001317325.1  protein Aster-B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 20 and 21, encodes isoform 4.
    Source sequence(s)
    AP000841, AP002765
    Consensus CDS
    CCDS81640.1
    UniProtKB/TrEMBL
    A0A024R3M2, A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  4. NM_001354837.2 → NP_001341766.1  protein Aster-B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AP000783, BI256024, BU622943
    Consensus CDS
    CCDS86254.1
    UniProtKB/TrEMBL
    A0A1B0GVV0
    Related
    ENSP00000490665.1, ENST00000533341.3

  5. NM_001367418.2 → NP_001354347.1  protein Aster-B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AP000841, AP001782, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:134 → 227
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:402 → 550
    DUF4782; Domain of unknown function (DUF4782)

  6. NM_001367419.2 → NP_001354348.1  protein Aster-B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AP000841, AP001782, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:134 → 227
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:402 → 550
    DUF4782; Domain of unknown function (DUF4782)

  7. NM_001367420.2 → NP_001354349.1  protein Aster-B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AP000841, AP001782, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:134 → 227
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:402 → 550
    DUF4782; Domain of unknown function (DUF4782)

  8. NM_001367421.2 → NP_001354350.1  protein Aster-B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AP000783, AP000841, AP001782, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7

  9. NM_001387024.1 → NP_001373953.1  protein Aster-B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AP000783, AP000841, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:250 → 343
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:518 → 666
    DUF4782; Domain of unknown function (DUF4782)

  10. NM_001387025.1 → NP_001373954.1  protein Aster-B isoform 11

    Status: VALIDATED

    Source sequence(s)
    AP000783, AP000841, AP002765
    Consensus CDS
    CCDS91613.1
    UniProtKB/TrEMBL
    A0A1B0GUD6, A0A1B0GWG7
    Related
    ENSP00000490062.1, ENST00000635736.2
    Conserved Domains (2) summary
    cd13220
    Location:250 → 343
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:518 → 666
    DUF4782; Domain of unknown function (DUF4782)

  11. NM_001387026.1 → NP_001373955.1  protein Aster-B isoform 12

    Status: VALIDATED

    Source sequence(s)
    AP000783, AP000841, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:249 → 342
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:517 → 665
    DUF4782; Domain of unknown function (DUF4782)

  12. NM_001387028.1 → NP_001373957.1  protein Aster-B isoform 13

    Status: VALIDATED

    Source sequence(s)
    AP000841, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:107 → 200
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:375 → 523
    DUF4782; Domain of unknown function (DUF4782)

  13. NM_001387029.1 → NP_001373958.1  protein Aster-B isoform 14

    Status: VALIDATED

    Source sequence(s)
    AP000841, AP002765
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:107 → 200
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:375 → 523
    DUF4782; Domain of unknown function (DUF4782)

  14. NM_001387030.1 → NP_001373959.1  protein Aster-B isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 15.
    Source sequence(s)
    AP000783, AP000841, AP002765
    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  15. NM_001387031.1 → NP_001373960.1  protein Aster-B isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 15.
    Source sequence(s)
    AP002765
    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  16. NM_001387032.1 → NP_001373961.1  protein Aster-B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 3 and 18, encodes isoform 3.
    Source sequence(s)
    AP000841, AP002765
    Consensus CDS
    CCDS66254.1
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  17. NM_001387033.1 → NP_001373962.1  protein Aster-B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 3 and 17, encodes isoform 3.
    Source sequence(s)
    AP000841, AP002765
    Consensus CDS
    CCDS66254.1
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Related
    ENSP00000490920.1, ENST00000638086.1
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  18. NM_001387034.1 → NP_001373963.1  protein Aster-B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 4 and 20, encodes isoform 4.
    Source sequence(s)
    AP000783, AP000841, AP002765
    Consensus CDS
    CCDS81640.1
    UniProtKB/TrEMBL
    A0A024R3M2, A0A1B0GWG7
    Related
    ENSP00000489896.1, ENST00000638157.1
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  19. NM_001387035.1 → NP_001373964.1  protein Aster-B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 4 and 19, encodes isoform 4.
    Source sequence(s)
    AP002765
    Consensus CDS
    CCDS81640.1
    UniProtKB/TrEMBL
    A0A024R3M2, A0A1B0GWG7
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  20. NM_020716.4 → NP_065767.1  protein Aster-B isoform 2

    See identical proteins and their annotated locations for NP_065767.1

    Status: VALIDATED

    Source sequence(s)
    AI815988, AK127457, AP000841, AP002765, BC107480
    Consensus CDS
    CCDS53720.1
    UniProtKB/Swiss-Prot
    B3KXJ5, E7EPH8, Q3KR37, Q6UW85, Q9ULL9
    UniProtKB/TrEMBL
    A0A1B0GWG7
    Related
    ENSP00000436500.1, ENST00000529750.5
    Conserved Domains (2) summary
    cd13220
    Location:107 → 200
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:375 → 523
    DUF4782; Domain of unknown function (DUF4782)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    123358422..123627767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427319.1 → XP_047283275.1  protein Aster-B isoform X1

  2. XM_047427324.1 → XP_047283280.1  protein Aster-B isoform X5

  3. XM_017018039.2 → XP_016873528.1  protein Aster-B isoform X10

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:134 → 227
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:406 → 550
    DUF4782; Domain of unknown function (DUF4782)

  4. XM_024448622.2 → XP_024304390.1  protein Aster-B isoform X12

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:108 → 201
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:380 → 524
    DUF4782; Domain of unknown function (DUF4782)

  5. XM_047427323.1 → XP_047283279.1  protein Aster-B isoform X5

  6. XM_006718892.4 → XP_006718955.1  protein Aster-B isoform X7

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:150 → 243
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:422 → 566
    DUF4782; Domain of unknown function (DUF4782)

  7. XM_011542926.3 → XP_011541228.1  protein Aster-B isoform X8

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:149 → 242
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:421 → 565
    DUF4782; Domain of unknown function (DUF4782)

  8. XM_017018040.2 → XP_016873529.1  protein Aster-B isoform X11

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:124 → 217
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:396 → 540
    DUF4782; Domain of unknown function (DUF4782)

  9. XM_047427322.1 → XP_047283278.1  protein Aster-B isoform X4

  10. XM_047427320.1 → XP_047283276.1  protein Aster-B isoform X2

  11. XM_047427321.1 → XP_047283277.1  protein Aster-B isoform X3

  12. XM_047427318.1 → XP_047283274.1  protein Aster-B isoform X1

  13. XM_047427327.1 → XP_047283283.1  protein Aster-B isoform X9

  14. XM_047427325.1 → XP_047283281.1  protein Aster-B isoform X6

  15. XM_047427330.1 → XP_047283286.1  protein Aster-B isoform X20

  16. XM_047427326.1 → XP_047283282.1  protein Aster-B isoform X18

  17. XM_017018046.2 → XP_016873535.1  protein Aster-B isoform X15

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  18. XM_011542931.3 → XP_011541233.1  protein Aster-B isoform X15

    See identical proteins and their annotated locations for XP_011541233.1

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:335 → 483
    DUF4782; Domain of unknown function (DUF4782)

  19. XM_005271619.5 → XP_005271676.1  protein Aster-B isoform X13

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:107 → 200
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:379 → 523
    DUF4782; Domain of unknown function (DUF4782)

  20. XM_047427328.1 → XP_047283284.1  protein Aster-B isoform X19

  21. XM_011542929.3 → XP_011541231.1  protein Aster-B isoform X14

    UniProtKB/TrEMBL
    B7Z4N9
    Conserved Domains (2) summary
    cd13220
    Location:103 → 196
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:375 → 519
    DUF4782; Domain of unknown function (DUF4782)

  22. XM_011542933.2 → XP_011541235.1  protein Aster-B isoform X16

    UniProtKB/TrEMBL
    A0A1B0GWG7, A0A2R8Y5X2
    Related
    ENSP00000494891.1, ENST00000646146.1
    Conserved Domains (2) summary
    cd13220
    Location:71 → 164
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:343 → 487
    DUF4782; Domain of unknown function (DUF4782)

  23. XM_047427331.1 → XP_047283287.1  protein Aster-B isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    123386861..123656743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369457.1 → XP_054225432.1  protein Aster-B isoform X1

  2. XM_054369462.1 → XP_054225437.1  protein Aster-B isoform X5

  3. XM_054369468.1 → XP_054225443.1  protein Aster-B isoform X10

  4. XM_054369472.1 → XP_054225447.1  protein Aster-B isoform X12

  5. XM_054369461.1 → XP_054225436.1  protein Aster-B isoform X5

  6. XM_054369470.1 → XP_054225445.1  protein Aster-B isoform X11

  7. XM_054369465.1 → XP_054225440.1  protein Aster-B isoform X7

  8. XM_054369466.1 → XP_054225441.1  protein Aster-B isoform X8

  9. XM_054369460.1 → XP_054225435.1  protein Aster-B isoform X4

  10. XM_054369458.1 → XP_054225433.1  protein Aster-B isoform X2

  11. XM_054369459.1 → XP_054225434.1  protein Aster-B isoform X3

  12. XM_054369467.1 → XP_054225442.1  protein Aster-B isoform X9

  13. XM_054369463.1 → XP_054225438.1  protein Aster-B isoform X6

  14. XM_054369464.1 → XP_054225439.1  protein Aster-B isoform X21

  15. XM_054369471.1 → XP_054225446.1  protein Aster-B isoform X23

  16. XM_054369476.1 → XP_054225451.1  protein Aster-B isoform X15

  17. XM_054369478.1 → XP_054225453.1  protein Aster-B isoform X15

  18. XM_054369481.1 → XP_054225456.1  protein Aster-B isoform X25

    UniProtKB/TrEMBL
    A0A024R3M2

  19. XM_054369474.1 → XP_054225449.1  protein Aster-B isoform X13

  20. XM_054369469.1 → XP_054225444.1  protein Aster-B isoform X22

  21. XM_054369473.1 → XP_054225448.1  protein Aster-B isoform X24

  22. XM_054369475.1 → XP_054225450.1  protein Aster-B isoform X14

  23. XM_054369477.1 → XP_054225452.1  protein Aster-B isoform X15

  24. XM_054369479.1 → XP_054225454.1  protein Aster-B isoform X16

    UniProtKB/TrEMBL
    A0A2R8Y5X2

  25. XM_054369480.1 → XP_054225455.1  protein Aster-B isoform X17

  26. XM_054369482.1 → XP_054225457.1  protein Aster-B isoform X26

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KR37.1 GenPept UniProtKB/Swiss-Prot:Q3KR37

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