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RNF150 ring finger protein 150 [ Homo sapiens (human) ]

Gene ID: 57484, updated on 5-Mar-2024

Summary

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Official Symbol
RNF150provided by HGNC
Official Full Name
ring finger protein 150provided by HGNC
Primary source
HGNC:HGNC:23138
See related
Ensembl:ENSG00000170153 AllianceGenome:HGNC:23138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 9.0), adrenal (RPKM 7.4) and 21 other tissues See more
Orthologs
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Genomic context

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See RNF150 in Genome Data Viewer
Location:
4q31.21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (140859807..141212900, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (144179641..144532545, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (141780961..142054623, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 9 Neighboring gene uncharacterized LOC124900787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21936 Neighboring gene uncharacterized LOC124900786 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:141677237-141677879 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:141677880-141678521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:141746857-141747378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:141747379-141747899 Neighboring gene Sharpr-MPRA regulatory region 7410 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:141972205-141972434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15715 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:142141834-142142340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:142142341-142142845 Neighboring gene zinc finger protein 330 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population. Ding Y, et al. Int J Chron Obstruct Pulmon Dis, 2015. PMID 25609945, Free PMC Article
  2. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Kim DK, et al. Am J Respir Crit Care Med, 2012 Dec 15. PMID 23144326, Free PMC Article
  3. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Pao KC, et al. Nature, 2018 Apr. PMID 29643511
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. van Wijk SJ, et al. Mol Syst Biol, 2009. PMID 19690564, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rs10007052 in the RNF150 gene is significantly associated with the risk of COPD in Chinese populations of Hainan province.
    Title: EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125502

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020724.2 → NP_065775.1  RING finger protein 150 precursor

    See identical proteins and their annotated locations for NP_065775.1

    Status: VALIDATED

    Source sequence(s)
    AB033040, AC093905, AC096733, AK130520
    Consensus CDS
    CCDS34065.1
    UniProtKB/Swiss-Prot
    Q3T1D0, Q6ZNW6, Q9ULK6
    Related
    ENSP00000425840.1, ENST00000515673.7
    Conserved Domains (3) summary
    cd02122
    Location:45 → 193
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:276 → 319
    zf-RING_2; Ring finger domain
    cl11506
    Location:207 → 232
    UPF0233; uncharacterized protein family (UPF0233)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    140859807..141212900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415998.1 → XP_047271954.1  RING finger protein 150 isoform X5

    UniProtKB/TrEMBL
    D6RIE5

  2. XM_011532148.4 → XP_011530450.1  RING finger protein 150 isoform X3

    See identical proteins and their annotated locations for XP_011530450.1

    UniProtKB/Swiss-Prot
    Q9ULK6
    Related
    ENSP00000394581.2, ENST00000420921.6
    Conserved Domains (3) summary
    pfam13639
    Location:135 → 178
    zf-RING_2; Ring finger domain
    cl10459
    Location:20 → 52
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
    cl11506
    Location:66 → 91
    UPF0233; uncharacterized protein family (UPF0233)

  3. XM_017008475.2 → XP_016863964.1  RING finger protein 150 isoform X4

  4. XM_047415996.1 → XP_047271952.1  RING finger protein 150 isoform X2

  5. XM_005263150.6 → XP_005263207.1  RING finger protein 150 isoform X1

    Conserved Domains (3) summary
    cd02122
    Location:45 → 215
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:298 → 341
    zf-RING_2; Ring finger domain
    cl11506
    Location:229 → 254
    UPF0233; uncharacterized protein family (UPF0233)

  6. XM_017008476.1 → XP_016863965.1  RING finger protein 150 isoform X5

    UniProtKB/TrEMBL
    D6RIE5
    Related
    ENSP00000425947.2, ENST00000506101.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    144179641..144532545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350568.1 → XP_054206543.1  RING finger protein 150 isoform X3

  2. XM_054350567.1 → XP_054206542.1  RING finger protein 150 isoform X1

  3. XM_054350569.1 → XP_054206544.1  RING finger protein 150 isoform X4

  4. XM_054350570.1 → XP_054206545.1  RING finger protein 150 isoform X5

    UniProtKB/TrEMBL
    D6RIE5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULK6.2 GenPept UniProtKB/Swiss-Prot:Q9ULK6

Gene LinkOut

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