ARID1B AT-rich interaction domain 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARID1Bprovided by HGNC
Official Full Name: AT-rich interaction domain 1Bprovided by HGNC
Primary source: HGNC:HGNC:18040
See related: Ensembl:ENSG00000049618 MIM:614556; AllianceGenome:HGNC:18040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CSS1; OSA2; 6A3-5; DAN15; MRD12; P250R; BRIGHT; BAF250B; SMARCF2; ELD/OSA1
Summary: This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Expression: Ubiquitous expression in thyroid (RPKM 7.6), skin (RPKM 7.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.3

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (156776026..157210779)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (157978277..158414307)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (157097160..157531913)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Genetic analysis of two children with Coffin-Siris syndrome due to variants of ARID1B gene].
Title: [Genetic analysis of two children with Coffin-Siris syndrome due to variants of ARID1B gene].
Correlation between ARID1B gene mutation (p.A460, p.V215G) and prognosis of high-risk refractory neuroblastoma.
Title: Correlation between ARID1B gene mutation (p.A460, p.V215G) and prognosis of high-risk refractory neuroblastoma.
Three Novel ARID1B Variations in Coffin-Siris Syndrome Patients.
Title: Three Novel ARID1B Variations in Coffin-Siris Syndrome Patients.
Paraspeckles interact with SWI/SNF subunit ARID1B to regulate transcription and splicing.
Title: Paraspeckles interact with SWI/SNF subunit ARID1B to regulate transcription and splicing.
ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease.
Title: ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease.
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes.
Title: Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes.
[Analysis of ARID1B gene variants in two Chinese pedigrees with Coffin-Siris syndrome].
Title: [Analysis of ARID1B gene variants in two Chinese pedigrees with Coffin-Siris syndrome].
Neurobiology of ARID1B haploinsufficiency related to neurodevelopmental and psychiatric disorders.
Title: Neurobiology of ARID1B haploinsufficiency related to neurodevelopmental and psychiatric disorders.
Downregulation of ARID1B, a tumor suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways.
Title: Downregulation of ARID1B, a tumor suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways.
Epilepsy features in ARID1B-related Coffin-Siris syndrome.
Title: Epilepsy features in ARID1B-related Coffin-Siris syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Coffin-Siris syndrome 1 MedGen: C3281201 OMIM: 135900 GeneReviews: Coffin-Siris Syndrome, ARID1B-Related Disorder	Compare labs

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2021-05-26) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2021-05-26) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46034 (e-PCR)
- UniSTS:29441

RH123307 (e-PCR)
- UniSTS:135684

RH68946 (e-PCR)
- UniSTS:9223

RH46824 (e-PCR)
- UniSTS:12298

RH63714 (e-PCR)
- UniSTS:21258

SHGC-35096 (e-PCR)
- UniSTS:76828

RH68798 (e-PCR)
- UniSTS:32284

SGC34328 (e-PCR)
- UniSTS:74026

D6S1878 (e-PCR)
- UniSTS:41260

D6S1163E (e-PCR)
- UniSTS:151091

RH68694 (e-PCR)
- UniSTS:70465

RH16172 (e-PCR)
- UniSTS:13387

SGC36816 (e-PCR)
- UniSTS:83543

SGC36953 (e-PCR)
- UniSTS:64343

ARID1B_8076 (e-PCR)
- UniSTS:467565

WI-16864 (e-PCR)
- UniSTS:79981

RH120849 (e-PCR)
- UniSTS:133504

SHGC-30226 (e-PCR)
- UniSTS:79275

RH46858 (e-PCR)
- UniSTS:19883

G34995 (e-PCR)
- UniSTS:66737

STS-T31821 (e-PCR)
- UniSTS:25009

RH119516 (e-PCR)
- UniSTS:133558

STS-D20286 (e-PCR)
- UniSTS:64205

A009L35 (e-PCR)
- UniSTS:43999

RH46651 (e-PCR)
- UniSTS:16615

G32659 (e-PCR)
- UniSTS:117241

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to angiotensin	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	NAS Non-traceable Author Statement more info	PubMed
part_of bBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of brahma complex	NAS Non-traceable Author Statement more info	PubMed
part_of chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
part_of nBAF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of npBAF complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 1B

Names: ARID domain-containing protein 1B; AT rich interactive domain 1B (SWI1-like); BRG1-associated factor 250b; BRG1-binding protein ELD/OSA1; ELD (eyelid)/OSA protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_066624.1 RefSeqGene

Range

6353..439754

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001363725.2 → NP_001350654.1 AT-rich interactive domain-containing protein 1B isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (4) is shorter at the N-terminus compared to isoform 3.

Source sequence(s)

AL049820, AL591545

Consensus CDS

CCDS87460.1

UniProtKB/TrEMBL

A0A1B0GVK1, A0A8J9GB59

Related

ENSP00000490550.1, ENST00000637904.1

Conserved Domains (3) summary

smart00501
Location:357 → 448

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam09606
Location:470 → 850

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam12031
Location:1230 → 1485

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa
NM_001371656.1 → NP_001358585.1 AT-rich interactive domain-containing protein 1B isoform 2

Status: REVIEWED

Source sequence(s)

AL049820, AL162578, AL355297, AL591545

Consensus CDS

CCDS55072.2

UniProtKB/TrEMBL

A0A3F2YNW7

Related

ENSP00000344546.5, ENST00000346085.10

Conserved Domains (3) summary

pfam09606
Location:1263 → 1643

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16877
Location:1150 → 1242

ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins

pfam12031
Location:2023 → 2278

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa
NM_001374820.1 → NP_001361749.1 AT-rich interactive domain-containing protein 1B isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

AL049820, AL162578, AL355297, AL591545

Consensus CDS

CCDS55072.2

UniProtKB/TrEMBL

A0A3F2YNW7

Conserved Domains (3) summary

pfam09606
Location:1263 → 1643

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16877
Location:1150 → 1242

ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins

pfam12031
Location:2023 → 2278

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa
NM_001374828.1 → NP_001361757.1 AT-rich interactive domain-containing protein 1B isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AL049820, AL162578, AL355297, AL591545

Consensus CDS

CCDS87459.2

UniProtKB/TrEMBL

A0A6Q8NVI4

Related

ENSP00000490491.2, ENST00000636930.2

Conserved Domains (5) summary

PRK10263
Location:756 → 944

PRK10263; DNA translocase FtsK; Provisional

pfam09606
Location:1303 → 1683

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16877
Location:1190 → 1282

ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins

pfam03154
Location:773 → 1128

Atrophin-1; Atrophin-1 family

pfam12031
Location:2063 → 2318

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa
NM_017519.3 → NP_059989.3 AT-rich interactive domain-containing protein 1B isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

AL049820, AL162578, AL355297, AL591545

Consensus CDS

CCDS5251.2

UniProtKB/Swiss-Prot

Q5JRD1, Q5VYC4, Q8IZY8, Q8NFD5, Q8TEV0, Q8TF02, Q99491, Q9ULI5

Related

ENSP00000055163.8, ENST00000350026.11

Conserved Domains (4) summary

PHA03307
Location:744 → 996

PHA03307; transcriptional regulator ICP4; Provisional

pfam09606
Location:1250 → 1630

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16877
Location:1137 → 1229

ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins

pfam12031
Location:2010 → 2265

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

156776026..157210779

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011535984.3 → XP_011534286.3 AT-rich interactive domain-containing protein 1B isoform X1
XM_017011105.3 → XP_016866594.2 AT-rich interactive domain-containing protein 1B isoform X6
XM_017011104.2 → XP_016866593.2 AT-rich interactive domain-containing protein 1B isoform X5
XM_017011106.3 → XP_016866595.2 AT-rich interactive domain-containing protein 1B isoform X15
XM_047419135.1 → XP_047275091.1 AT-rich interactive domain-containing protein 1B isoform X9
XM_017011107.3 → XP_016866596.2 AT-rich interactive domain-containing protein 1B isoform X17
XM_047419150.1 → XP_047275106.1 AT-rich interactive domain-containing protein 1B isoform X25
XM_047419138.1 → XP_047275094.1 AT-rich interactive domain-containing protein 1B isoform X12
XM_047419146.1 → XP_047275102.1 AT-rich interactive domain-containing protein 1B isoform X21
XM_047419131.1 → XP_047275087.1 AT-rich interactive domain-containing protein 1B isoform X3
XM_047419137.1 → XP_047275093.1 AT-rich interactive domain-containing protein 1B isoform X11
XM_047419134.1 → XP_047275090.1 AT-rich interactive domain-containing protein 1B isoform X8
XM_047419145.1 → XP_047275101.1 AT-rich interactive domain-containing protein 1B isoform X20
XM_047419151.1 → XP_047275107.1 AT-rich interactive domain-containing protein 1B isoform X26
XM_047419141.1 → XP_047275097.1 AT-rich interactive domain-containing protein 1B isoform X14
XM_047419130.1 → XP_047275086.1 AT-rich interactive domain-containing protein 1B isoform X2
XM_047419136.1 → XP_047275092.1 AT-rich interactive domain-containing protein 1B isoform X10
XM_047419133.1 → XP_047275089.1 AT-rich interactive domain-containing protein 1B isoform X7
XM_047419143.1 → XP_047275099.1 AT-rich interactive domain-containing protein 1B isoform X18
XM_047419144.1 → XP_047275100.1 AT-rich interactive domain-containing protein 1B isoform X19
XM_047419132.1 → XP_047275088.1 AT-rich interactive domain-containing protein 1B isoform X4

UniProtKB/TrEMBL

A0A1B0GTJ8

Related

ENSP00000489729.2, ENST00000637015.2
XM_047419140.1 → XP_047275096.1 AT-rich interactive domain-containing protein 1B isoform X13
XM_047419148.1 → XP_047275104.1 AT-rich interactive domain-containing protein 1B isoform X23
XM_047419147.1 → XP_047275103.1 AT-rich interactive domain-containing protein 1B isoform X22
XM_047419152.1 → XP_047275108.1 AT-rich interactive domain-containing protein 1B isoform X27
XM_047419142.1 → XP_047275098.1 AT-rich interactive domain-containing protein 1B isoform X16

UniProtKB/TrEMBL

H0Y7H8

Related

ENSP00000412835.3, ENST00000414678.8
XM_047419149.1 → XP_047275105.1 AT-rich interactive domain-containing protein 1B isoform X24
XM_047419155.1 → XP_047275111.1 AT-rich interactive domain-containing protein 1B isoform X30
XM_047419153.1 → XP_047275109.1 AT-rich interactive domain-containing protein 1B isoform X28
XM_047419154.1 → XP_047275110.1 AT-rich interactive domain-containing protein 1B isoform X29
XM_011535988.4 → XP_011534290.1 AT-rich interactive domain-containing protein 1B isoform X31

UniProtKB/TrEMBL

A0A1B0GV63

Related

ENSP00000490385.1, ENST00000635957.1

Conserved Domains (4) summary

smart00501
Location:154 → 245

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam09606
Location:277 → 711

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam03353
Location:588 → 666

Lin-8; Ras-mediated vulval-induction antagonizt

pfam12031
Location:1027 → 1282

DUF3518; Domain of unknown function (DUF3518)
XM_047419156.1 → XP_047275112.1 AT-rich interactive domain-containing protein 1B isoform X32

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

157978277..158414307

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356030.1 → XP_054212005.1 AT-rich interactive domain-containing protein 1B isoform X1
XM_054356035.1 → XP_054212010.1 AT-rich interactive domain-containing protein 1B isoform X6
XM_054356034.1 → XP_054212009.1 AT-rich interactive domain-containing protein 1B isoform X5
XM_054356044.1 → XP_054212019.1 AT-rich interactive domain-containing protein 1B isoform X15
XM_054356038.1 → XP_054212013.1 AT-rich interactive domain-containing protein 1B isoform X9
XM_054356046.1 → XP_054212021.1 AT-rich interactive domain-containing protein 1B isoform X17
XM_054356054.1 → XP_054212029.1 AT-rich interactive domain-containing protein 1B isoform X25
XM_054356041.1 → XP_054212016.1 AT-rich interactive domain-containing protein 1B isoform X12
XM_054356050.1 → XP_054212025.1 AT-rich interactive domain-containing protein 1B isoform X21
XM_054356032.1 → XP_054212007.1 AT-rich interactive domain-containing protein 1B isoform X3
XM_054356040.1 → XP_054212015.1 AT-rich interactive domain-containing protein 1B isoform X11
XM_054356037.1 → XP_054212012.1 AT-rich interactive domain-containing protein 1B isoform X8
XM_054356049.1 → XP_054212024.1 AT-rich interactive domain-containing protein 1B isoform X20
XM_054356055.1 → XP_054212030.1 AT-rich interactive domain-containing protein 1B isoform X26
XM_054356043.1 → XP_054212018.1 AT-rich interactive domain-containing protein 1B isoform X14
XM_054356031.1 → XP_054212006.1 AT-rich interactive domain-containing protein 1B isoform X2
XM_054356039.1 → XP_054212014.1 AT-rich interactive domain-containing protein 1B isoform X10
XM_054356036.1 → XP_054212011.1 AT-rich interactive domain-containing protein 1B isoform X7
XM_054356047.1 → XP_054212022.1 AT-rich interactive domain-containing protein 1B isoform X18
XM_054356048.1 → XP_054212023.1 AT-rich interactive domain-containing protein 1B isoform X19
XM_054356033.1 → XP_054212008.1 AT-rich interactive domain-containing protein 1B isoform X4

UniProtKB/TrEMBL

A0A1B0GTJ8
XM_054356042.1 → XP_054212017.1 AT-rich interactive domain-containing protein 1B isoform X13
XM_054356052.1 → XP_054212027.1 AT-rich interactive domain-containing protein 1B isoform X23
XM_054356051.1 → XP_054212026.1 AT-rich interactive domain-containing protein 1B isoform X22
XM_054356056.1 → XP_054212031.1 AT-rich interactive domain-containing protein 1B isoform X27
XM_054356045.1 → XP_054212020.1 AT-rich interactive domain-containing protein 1B isoform X16

UniProtKB/TrEMBL

H0Y7H8
XM_054356053.1 → XP_054212028.1 AT-rich interactive domain-containing protein 1B isoform X24
XM_054356059.1 → XP_054212034.1 AT-rich interactive domain-containing protein 1B isoform X30
XM_054356057.1 → XP_054212032.1 AT-rich interactive domain-containing protein 1B isoform X28
XM_054356058.1 → XP_054212033.1 AT-rich interactive domain-containing protein 1B isoform X29
XM_054356060.1 → XP_054212035.1 AT-rich interactive domain-containing protein 1B isoform X31
XM_054356061.1 → XP_054212036.1 AT-rich interactive domain-containing protein 1B isoform X32

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_032093.2: Suppressed sequence

Description

NG_032093.2: This RefSeq was removed because it was a RefSeqGene reference standard corresponding to LRG_861, which is being deprecated as the CDS was determined to be incorrectly annotated on the included reference transcripts.