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TRMT9B tRNA methyltransferase 9B (putative) [ Homo sapiens (human) ]

Gene ID: 57604, updated on 5-Mar-2024

Summary

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Official Symbol
TRMT9Bprovided by HGNC
Official Full Name
tRNA methyltransferase 9B (putative)provided by HGNC
Primary source
HGNC:HGNC:26725
See related
Ensembl:ENSG00000250305 MIM:615666; AllianceGenome:HGNC:26725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM9L; hTRM9L; C8orf79; KIAA1456
Summary
Enables tRNA methyltransferase activity. Predicted to be involved in tRNA wobble uridine modification. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 9.8), brain (RPKM 1.5) and 7 other tissues See more
Orthologs
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Genomic context

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Location:
8p22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (12945673..13029777)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (13211952..13296089)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (12803182..12887286)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3019 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12651516-12652033 Neighboring gene long intergenic non-protein coding RNA 681 Neighboring gene uncharacterized LOC105379289 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12726438-12727079 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12758236-12758737 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12799399-12799938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12808376-12808876 Neighboring gene regulator of solute carriers 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12829815-12830334 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:12834091-12834678 Neighboring gene uncharacterized LOC124901889 Neighboring gene Sharpr-MPRA regulatory region 1393 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:12898718-12898926 Neighboring gene uncharacterized LOC124902103 Neighboring gene RNA, U6 small nuclear 842, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Overexpression of KIAA1456 inhibits the proliferation of HO8910PM cells]. Chen H, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2016 Sep. PMID 27609572
  2. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. Begley U, et al. EMBO Mol Med, 2013 Mar. PMID 23381944, Free PMC Article
  3. A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample. Wolf EJ, et al. Depress Anxiety, 2014 Apr. PMID 24677629, Free PMC Article
  4. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. Lunetta KL, et al. BMC Med Genet, 2007 Sep 19. PMID 17903295, Free PMC Article
  5. Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Figueiredo JC, et al. PLoS Genet, 2014 Apr. PMID 24743840, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Over-expression of KIAA1456 inhibits the proliferation of HO8910PM ovarian cancer cells and arrests the cell cycle in G1 phase.
    Title: [Overexpression of KIAA1456 inhibits the proliferation of HO8910PM cells].
  2. Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms.
    Title: A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36980, KIAA1456, MGC43113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA methyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification TAS
Traceable Author Statement
more info
  
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable tRNA methyltransferase 9B
Names
probable tRNA methyltransferase 9-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099677.1 → NP_001093147.1  probable tRNA methyltransferase 9B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC135352, AK125638, AW295329, DR001645

  2. NM_020844.3 → NP_065895.2  probable tRNA methyltransferase 9B isoform 1

    See identical proteins and their annotated locations for NP_065895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB040889, AC135352, AW295329, DA390356, DC334299
    Consensus CDS
    CCDS47808.1
    UniProtKB/Swiss-Prot
    K7EM26, Q8N9K7, Q96AW6, Q9P272
    Related
    ENSP00000432695.1, ENST00000524591.7
    Conserved Domains (1) summary
    pfam13649
    Location:48 → 135
    Methyltransf_25; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    12945673..13029777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    6141094..6225206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    13211952..13296089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P272.3 GenPept UniProtKB/Swiss-Prot:Q9P272

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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