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PTPRG protein tyrosine phosphatase receptor type G [ Homo sapiens (human) ]

Gene ID: 5793, updated on 11-Apr-2024

Summary

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Official Symbol
PTPRGprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Gprovided by HGNC
Primary source
HGNC:HGNC:9671
See related
Ensembl:ENSG00000144724 MIM:176886; AllianceGenome:HGNC:9671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPG; HPTPG; RPTPG; R-PTP-GAMMA
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 11.5), kidney (RPKM 9.0) and 23 other tissues See more
Orthologs
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Genomic context

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See PTPRG in Genome Data Viewer
Location:
3p14.2
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (61561571..62297609)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (61604735..62341118)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (61547245..62283284)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909387 Neighboring gene uncharacterized LOC105377114 Neighboring gene Sharpr-MPRA regulatory region 1523 Neighboring gene uncharacterized LOC105377115 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61317711-61318325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14495 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:61404092-61404295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:61490728-61491228 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:61491229-61491729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61545347-61546022 Neighboring gene uncharacterized LOC124909388 Neighboring gene uncharacterized LOC124906245 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:61657567-61658404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61665901-61666400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61671542-61672277 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61673811-61674444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61676017-61676556 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61677824-61678324 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61678325-61678825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61678925-61679473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61680893-61681393 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61685048-61685943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61686839-61687733 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61689953-61690680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61690681-61691408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61700687-61701188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:61701189-61701688 Neighboring gene ribosomal protein L10a pseudogene 6 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:61815091-61815694 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:61815695-61816299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61852378-61852880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:61852881-61853381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61857459-61858243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:61860549-61861255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:61932324-61933045 Neighboring gene Sharpr-MPRA regulatory region 14465 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:62026884-62028083 Neighboring gene NANOG hESC enhancer GRCh37_chr3:62155504-62156044 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_70816 Neighboring gene RNA, U2 small nuclear 10, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62175493-62176339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:62176867-62177367 Neighboring gene uncharacterized LOC124909389 Neighboring gene inhibitor of DNA binding 2B (pseudogene) Neighboring gene PTPRG antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9750 Neighboring gene VISTA enhancer hs434 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62353809-62354715 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62354716-62355621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62357949-62358508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62358509-62359066 Neighboring gene centrosomal protein 15 Neighboring gene FEZ family zinc finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling. Joshi MS, et al. EMBO J, 2023 May 15. PMID 36988334, Free PMC Article
  2. Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG. Lombardi G, et al. Int J Mol Sci, 2022 Aug 31. PMID 36077295, Free PMC Article
  3. A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease. Boni C, et al. Biomolecules, 2022 Jan 6. PMID 35053232, Free PMC Article
  4. Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors. Ismail MA, et al. Gene, 2022 Mar 1. PMID 34906644
  5. Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells. Montresor A, et al. J Immunol, 2021 Jul 15. PMID 34162728

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The EGFR phosphatase RPTPgamma is a redox-regulated suppressor of promigratory signaling.
    Title: The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling.
  2. Loss of RPTPgamma primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.
    Title: Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.
  3. Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG.
    Title: Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG.
  4. A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease.
    Title: A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease.
  5. Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors.
    Title: Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors.
  6. Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients.
    Title: Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients.
  7. Activation of Protein Tyrosine Phosphatase Receptor Type gamma Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells.
    Title: Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells.
  8. Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.
    Title: Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.
  9. PTPRG is an ischemia risk locus essential for HCO3(-)-dependent regulation of endothelial function and tissue perfusion.
    Title: PTPRG is an ischemia risk locus essential for HCO(3)(-)-dependent regulation of endothelial function and tissue perfusion.
  10. Regulative Loop between beta-catenin and Protein Tyrosine Receptor Type gamma in Chronic Myeloid Leukemia.
    Title: Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
EBI GWAS Catalog
E2-2 protein and Fuchs's corneal dystrophy.
EBI GWAS Catalog
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog
Genome-wide association study identifies five new schizophrenia loci.
EBI GWAS Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog
Genome-wide association study of recurrent early-onset major depressive disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in regulation of homophilic cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase gamma
Names
H_RG317H01.1
protein tyrosine phosphatase gamma
protein tyrosine phosphatase, receptor type, gamma polypeptide
receptor type protein tyrosine phosphatase gamma
receptor tyrosine phosphatase gamma
receptor-type protein phosphatase gamma
NP_001362400.1
NP_002832.3
XP_016862450.1
XP_016862451.1
XP_016862452.1
XP_047304601.1
XP_047304602.1
XP_054203384.1
XP_054203385.1
XP_054203386.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375471.1 → NP_001362400.1  receptor-type tyrosine-protein phosphatase gamma isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004695, AC092502, AC096919, AC098482, AC103587, AC104849
    Consensus CDS
    CCDS93303.1
    Related
    ENSP00000295874.10, ENST00000295874.14
    Conserved Domains (5) summary
    PHA03169
    Location:544 → 702
    PHA03169; hypothetical protein; Provisional
    cd00063
    Location:348 → 438
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd03122
    Location:67 → 319
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    cd17667
    Location:819 → 1092
    R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1
    cd17670
    Location:1176 → 1380
    R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2

  2. NM_002841.4 → NP_002832.3  receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_002832.3

    Status: REVIEWED

    Source sequence(s)
    AC092502, BC036018, BC140904
    Consensus CDS
    CCDS2895.1
    UniProtKB/Swiss-Prot
    B2RU12, B7ZLX5, P23470, Q15623, Q59EE0, Q68DU5
    Related
    ENSP00000418112.1, ENST00000474889.6
    Conserved Domains (5) summary
    PHA03169
    Location:544 → 702
    PHA03169; hypothetical protein; Provisional
    cd00063
    Location:348 → 438
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd03122
    Location:67 → 319
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    cd17667
    Location:848 → 1121
    R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1
    cd17670
    Location:1205 → 1409
    R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    61561571..62297609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006961.2 → XP_016862450.1  receptor-type tyrosine-protein phosphatase gamma isoform X1

  2. XM_017006963.2 → XP_016862452.1  receptor-type tyrosine-protein phosphatase gamma isoform X3

  3. XM_047448646.1 → XP_047304602.1  receptor-type tyrosine-protein phosphatase gamma isoform X4

  4. XM_047448645.1 → XP_047304601.1  receptor-type tyrosine-protein phosphatase gamma isoform X4

  5. XM_017006962.1 → XP_016862451.1  receptor-type tyrosine-protein phosphatase gamma isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    61604735..62341118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347409.1 → XP_054203384.1  receptor-type tyrosine-protein phosphatase gamma isoform X1

  2. XM_054347411.1 → XP_054203386.1  receptor-type tyrosine-protein phosphatase gamma isoform X3

  3. XM_054347410.1 → XP_054203385.1  receptor-type tyrosine-protein phosphatase gamma isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23470.4 GenPept UniProtKB/Swiss-Prot:P23470

Gene LinkOut

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