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RGL2 ral guanine nucleotide dissociation stimulator like 2 [ Homo sapiens (human) ]

Gene ID: 5863, updated on 3-Apr-2024

Summary

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Official Symbol
RGL2provided by HGNC
Official Full Name
ral guanine nucleotide dissociation stimulator like 2provided by HGNC
Primary source
HGNC:HGNC:9769
See related
Ensembl:ENSG00000237441 MIM:602306; AllianceGenome:HGNC:9769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KE1.5; RAB2L; HKE1.5
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to act upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 40.1), prostate (RPKM 26.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RGL2 in Genome Data Viewer
Location:
6p21.32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33291654..33301612, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33113016..33120834, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33259431..33266719, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 46 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255009-33255542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255543-33256076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33256611-33257144 Neighboring gene microRNA 6873 Neighboring gene microRNA 6834 Neighboring gene prefoldin subunit 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33265070-33265597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33265684-33266184 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33266952-33267130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33267887-33268394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33268395-33268900 Neighboring gene TAP binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33282409-33283068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33283069-33283726 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene uncharacterized LOC124901303 Neighboring gene death domain associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. G-protein binding features and regulation of the RalGDS family member, RGL2. Ferro E, et al. Biochem J, 2008 Oct 1. PMID 18540861
  2. cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions. Ando A, et al. Immunogenetics, 1999 Apr. PMID 10079301
  3. Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS. Isomura M, et al. Cytogenet Cell Genet, 1996. PMID 8976381
  4. Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. Vigil D, et al. J Biol Chem, 2010 Nov 5. PMID 20801877, Free PMC Article
  5. Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis. Hershkovitz D, et al. J Invest Dermatol, 2011 Mar. PMID 21160498, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAMD9, an IFN-gamma-responsive protein, interacts with RGL2 to diminish the expression of EGR1, a protein of direct relevance to the pathogenesis of ectopic calcification and inflammation.
    Title: Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis.
  2. Rgl2 and RalB both localized to the leading edge, and this localization of RalB was dependent on endogenous Rgl2 expression.
    Title: Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  4. RGL2 is phosphorylated by PKA and phosphorylation reduces the ability of RGL2 to bind H-Ras. results of the present study indicate that Ras may distinguish between the different RalGDS family members by their phosphorylation by PKA.
    Title: G-protein binding features and regulation of the RalGDS family member, RGL2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of ral guanine nucleotide dissociation stimulator-like 2 (RGL2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Ral protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator-like 2
Names
GDS-related protein
ralGDS-like 2
ralGDS-like factor
ras-associated protein RAB2L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243738.2 → NP_001230667.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001230667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL050259, BX648015, DA158284
    UniProtKB/TrEMBL
    Q9BSI0
    Related
    ENST00000437840.6
    Conserved Domains (3) summary
    cd00153
    Location:566 → 651
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:157 → 431
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8 → 130
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

  2. NM_004761.5 → NP_004752.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 1

    See identical proteins and their annotated locations for NP_004752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL050259, BX648015
    Consensus CDS
    CCDS4774.1
    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9, A0A1U9X8E4, A0A1U9X8F0
    Related
    ENSP00000420211.1, ENST00000497454.6
    Conserved Domains (3) summary
    cd00153
    Location:648 → 733
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:239 → 513
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:90 → 212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    33291654..33301612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419202.1 → XP_047275158.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

  2. XM_047419203.1 → XP_047275159.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  3. XM_047419201.1 → XP_047275157.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

  4. XM_047419200.1 → XP_047275156.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X5

  5. XM_047419199.1 → XP_047275155.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

  6. XM_011514785.4 → XP_011513087.2  ral guanine nucleotide dissociation stimulator-like 2 isoform X6

  7. XM_047419205.1 → XP_047275161.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X8

  8. XM_047419204.1 → XP_047275160.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X7

RNA

  1. XR_007059286.1 RNA Sequence

  2. XR_007059287.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    4703139..4710957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329839.1 → XP_054185814.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

  2. XM_054329840.1 → XP_054185815.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

  3. XM_054329837.1 → XP_054185812.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X11

    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9

  4. XM_054329841.1 → XP_054185816.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  5. XM_054329836.1 → XP_054185811.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

  6. XM_054329838.1 → XP_054185813.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  7. XM_054329842.1 → XP_054185817.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X9

  8. XM_054329843.1 → XP_054185818.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X10

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    4535172..4542990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330324.1 → XP_054186299.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

  2. XM_054330325.1 → XP_054186300.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

  3. XM_054330322.1 → XP_054186297.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X11

    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9

  4. XM_054330326.1 → XP_054186301.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  5. XM_054330321.1 → XP_054186296.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

  6. XM_054330323.1 → XP_054186298.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  7. XM_054330327.1 → XP_054186302.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X12

  8. XM_054330328.1 → XP_054186303.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X13

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    4727590..4735521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330841.1 → XP_054186816.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

  2. XM_054330840.1 → XP_054186815.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

  3. XM_054330842.1 → XP_054186817.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  4. XM_054330838.1 → XP_054186813.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

  5. XM_054330839.1 → XP_054186814.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  6. XM_054330843.1 → XP_054186818.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X14

  7. XM_054330844.1 → XP_054186819.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X15

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    4486078..4494006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331101.1 → XP_054187076.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

  2. XM_054331100.1 → XP_054187075.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

  3. XM_054331098.1 → XP_054187073.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X11

    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9

  4. XM_054331102.1 → XP_054187077.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  5. XM_054331097.1 → XP_054187072.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

  6. XM_054331099.1 → XP_054187074.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  7. XM_054331103.1 → XP_054187078.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X16

  8. XM_054331104.1 → XP_054187079.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    33113016..33120834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356133.1 → XP_054212108.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

  2. XM_054356134.1 → XP_054212109.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

  3. XM_054356135.1 → XP_054212110.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  4. XM_054356131.1 → XP_054212106.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

  5. XM_054356132.1 → XP_054212107.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

  6. XM_054356136.1 → XP_054212111.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X18

  7. XM_054356137.1 → XP_054212112.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X19

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15211.1 GenPept UniProtKB/Swiss-Prot:O15211

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