U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HIVEP3 HIVEP zinc finger 3 [ Homo sapiens (human) ]

Gene ID: 59269, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
HIVEP3provided by HGNC
Official Full Name
HIVEP zinc finger 3provided by HGNC
Primary source
HGNC:HGNC:13561
See related
Ensembl:ENSG00000127124 MIM:606649; AllianceGenome:HGNC:13561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRC; KBP1; SHN3; ZAS3; KBP-1; ZNF40C; Schnurri-3
Summary
This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in skin (RPKM 2.3), brain (RPKM 1.1) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p34.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (41506365..42035934, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (41376570..41906502, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41972036..42501605, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41942603-41943309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41947626-41948612 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:41951461-41952660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41959702-41960232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41961826-41962374 Neighboring gene RNA, 5S ribosomal pseudogene 45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41968132-41968632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41978699-41979199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41987015-41987609 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:42006631-42006845 Neighboring gene vir like m6A methyltransferase associated pseudogene Neighboring gene endothelin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 869 Neighboring gene uncharacterized LOC128125817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42136496-42137086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:42138269-42138858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42156217-42156717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42198929-42199430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 886 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:42289027-42289544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 754 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:42353785-42353994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 890 Neighboring gene Sharpr-MPRA regulatory region 8090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 755 Neighboring gene uncharacterized LOC124904160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 756 Neighboring gene uncharacterized LOC124904161 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia. Tang Y, et al. Growth Factors, 2023 Feb. PMID 36571205
  2. HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia. Zhang X, et al. Cancer Med, 2022 Dec. PMID 35535739, Free PMC Article
  3. Genetics of intellectual disability in consanguineous families. Hu H, et al. Mol Psychiatry, 2019 Jul. PMID 29302074
  4. Increased sensitivity of rheumatoid synoviocytes to Schnurri-3 expression in TNF-α and IL-17A induced osteoblastic differentiation. Lavocat F, et al. Bone, 2016 Jun. PMID 27072520
  5. Effect of lyso-phosphatidylcholine and Schnurri-3 on osteogenic transdifferentiation of vascular smooth muscle cells to calcifying vascular cells in 3D culture. Castro-Chavez F, et al. Biochim Biophys Acta, 2013 Jun. PMID 23500015, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia.
    Title: HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia.
  2. HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia.
    Title: HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia.
  3. The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3.
    Title: The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3.
  4. rheumatoid arthritis-fibroblast-like synoviocytes were more sensitive to the synergistic increase of Schnurri-3 expression.
    Title: Increased sensitivity of rheumatoid synoviocytes to Schnurri-3 expression in TNF-α and IL-17A induced osteoblastic differentiation.
  5. Transdifferentiation of VSMC into calcifying vascular cells is enhanced by LPC and attenuated by Schnurri-3.
    Title: Effect of lyso-phosphatidylcholine and Schnurri-3 on osteogenic transdifferentiation of vascular smooth muscle cells to calcifying vascular cells in 3D culture.
  6. ZAS3 expression is directly regulated by estrogen and is overexpressed in lupus. Its upregulation by estrogen could play a critical role in female-biased autoimmune disorders.
    Title: Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.
  7. The inhibitory effect of ZAS3 on NF-kappa B activity is mediated by neither direct association with N-kappa B nor disrupting nuclear localization of NFvarkappaB.
    Title: ZAS3 promotes TNFα-induced apoptosis by blocking NFϰB-activated expression of the anti-apoptotic genes TRAF1 and TRAF2.
  8. DNA competition by ZAS3 is sufficient to repress transcription activated by NF-kappaB and that ZAS3 is an endogenous kappaB-motif competitor with ininsic repression activity.
    Title: ZAS3 represses NFκB-dependent transcription by direct competition for DNA binding.
  9. An interaction between ZAS3 and Smad proteins enhances transforming growth factor beta signaling.
    Title: ZAS3 accentuates transforming growth factor β signaling in epithelial cells.
  10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2019-01-23)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2019-01-23)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
EBI GWAS Catalog
Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ16752, KIAA1555

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor HIVEP3
Names
ZAS family, member 3
human immunodeficiency virus type I enhancer binding protein 3
kappa-B and V(D)J recombination signal sequences-binding protein
kappa-binding protein 1
zinc finger protein ZAS3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030026.2 RefSeqGene

    Range
    122004..534561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127714.3 → NP_001121186.1  transcription factor HIVEP3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC105268, AC119676, AI082114, AL445933, BC152563
    Consensus CDS
    CCDS44124.1
    UniProtKB/Swiss-Prot
    Q5T1R4
    Related
    ENSP00000361665.1, ENST00000372584.5
    Conserved Domains (3) summary
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1754 → 1776
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain

  2. NM_024503.5 → NP_078779.2  transcription factor HIVEP3 isoform a

    See identical proteins and their annotated locations for NP_078779.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC105268, AF278765, AI082114, AL445933, BC152563
    Consensus CDS
    CCDS463.1
    UniProtKB/Swiss-Prot
    A7YY91, Q5T1R4, Q5T1R5, Q9BZS0, Q9HCL7
    Related
    ENSP00000361664.1, ENST00000372583.6
    Conserved Domains (4) summary
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1754 → 1776
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:1877 → 2395
    Atrophin-1; Atrophin-1 family

RNA

  1. NR_038260.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks all but the first exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC105268, BC040942, BG213993, DA093318
    Related
    ENST00000491442.5

  2. NR_038261.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks all but the first exon, and contains an alternate 5' and two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AL158216, BC046120, BG213993
    Related
    ENST00000489103.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    41506365..42035934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426877.1 → XP_047282833.1  transcription factor HIVEP3 isoform X4

  2. XM_047426875.1 → XP_047282831.1  transcription factor HIVEP3 isoform X1

  3. XM_011541885.4 → XP_011540187.1  transcription factor HIVEP3 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011541887.4 → XP_011540189.1  transcription factor HIVEP3 isoform X5

    Conserved Domains (2) summary
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011541886.4 → XP_011540188.1  transcription factor HIVEP3 isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:207 → 231
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_007062478.1 RNA Sequence

  2. XR_007062479.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    41376570..41906502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338008.1 → XP_054193983.1  transcription factor HIVEP3 isoform X4

  2. XM_054338005.1 → XP_054193980.1  transcription factor HIVEP3 isoform X1

  3. XM_054338006.1 → XP_054193981.1  transcription factor HIVEP3 isoform X2

  4. XM_054338009.1 → XP_054193984.1  transcription factor HIVEP3 isoform X5

  5. XM_054338007.1 → XP_054193982.1  transcription factor HIVEP3 isoform X3

RNA

  1. XR_008486133.1 RNA Sequence

  2. XR_008486134.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T1R4.1 GenPept UniProtKB/Swiss-Prot:Q5T1R4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous