MMP19 matrix metallopeptidase 19 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MMP19provided by VGNC
Official Full Name: matrix metallopeptidase 19provided by VGNC
Primary source: VGNC:VGNC:43279
See related: Ensembl:ENSCAFG00845005600
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	10	NC_051814.1 (225879..231709, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	10	NC_006592.4 (281068..286898, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	10	NC_049231.1 (570854..576684, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	10	NC_049270.1 (203820..209650, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	10	NC_049751.1 (446639..452469, complement)

Chromosome 10 - NC_051814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: matrix metalloproteinase-19

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051814.1 Reference ROS_Cfam_1.0

Range

225879..231709 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038678923.1 → XP_038534851.1 matrix metalloproteinase-19 isoform X3

Conserved Domains (3) summary

cd00094
Location:204 → 390

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain

cl00064
Location:104 → 175

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_038678921.1 → XP_038534849.1 matrix metalloproteinase-19 isoform X1

UniProtKB/TrEMBL

A0A8C0LRI5, A0A8C0PZW6, A0A8I3MTX4

Related

ENSCAFP00845007765.1, ENSCAFT00845009954.1

Conserved Domains (3) summary

cd00094
Location:286 → 472

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:104 → 257

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain
XM_038678922.1 → XP_038534850.1 matrix metalloproteinase-19 isoform X2

Conserved Domains (2) summary

cd00094
Location:206 → 392

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:24 → 177

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049270.1 Alternate UMICH_Zoey_3.1

Range

203820..209650 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038487701.1 → XP_038343629.1 matrix metalloproteinase-19 isoform X3

Conserved Domains (3) summary

cd00094
Location:204 → 390

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain

cl00064
Location:104 → 175

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_038487699.1 → XP_038343627.1 matrix metalloproteinase-19 isoform X1

Conserved Domains (3) summary

cd00094
Location:286 → 472

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:104 → 257

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain
XM_038487700.1 → XP_038343628.1 matrix metalloproteinase-19 isoform X2

Conserved Domains (2) summary

cd00094
Location:206 → 392

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:24 → 177

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049751.1 Alternate UNSW_CanFamBas_1.0

Range

446639..452469 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038613561.1 → XP_038469489.1 matrix metalloproteinase-19 isoform X3

Conserved Domains (3) summary

cd00094
Location:204 → 390

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain

cl00064
Location:104 → 175

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_038613559.1 → XP_038469487.1 matrix metalloproteinase-19 isoform X1

Conserved Domains (3) summary

cd00094
Location:286 → 472

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:104 → 257

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain
XM_038613560.1 → XP_038469488.1 matrix metalloproteinase-19 isoform X2

Conserved Domains (2) summary

cd00094
Location:206 → 392

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:24 → 177

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049231.1 Alternate UU_Cfam_GSD_1.0

Range

570854..576684 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038549589.1 → XP_038405517.1 matrix metalloproteinase-19 isoform X3

Conserved Domains (3) summary

cd00094
Location:204 → 390

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain

cl00064
Location:104 → 175

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_038549587.1 → XP_038405515.1 matrix metalloproteinase-19 isoform X1

UniProtKB/TrEMBL

A0A8C0LRI5, A0A8C0PZW6, A0A8I3MTX4

Conserved Domains (3) summary

cd00094
Location:286 → 472

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:104 → 257

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain
XM_038549588.1 → XP_038405516.1 matrix metalloproteinase-19 isoform X2

Conserved Domains (2) summary

cd00094
Location:206 → 392

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:24 → 177

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

281068..286898 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022424024.2 → XP_022279732.1 matrix metalloproteinase-19 isoform X3

Conserved Domains (3) summary

cd00094
Location:204 → 390

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain

cl00064
Location:104 → 175

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_005625468.4 → XP_005625525.1 matrix metalloproteinase-19 isoform X1

UniProtKB/TrEMBL

A0A8C0LRI5, A0A8C0PZW6, A0A8I3MTX4

Conserved Domains (3) summary

cd00094
Location:286 → 472

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:104 → 257

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:32 → 81

PG_binding_1; Putative peptidoglycan binding domain
XM_022424023.2 → XP_022279731.1 matrix metalloproteinase-19 isoform X2

Conserved Domains (2) summary

cd00094
Location:206 → 392

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:24 → 177

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...