U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 [ Canis lupus familiaris (dog) ]

Gene ID: 609956, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PIK3R2provided by VGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 2provided by VGNC
Primary source
VGNC:VGNC:81919
See related
Ensembl:ENSCAFG00845023471
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PIK3R2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (45311340..45323770, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (44739520..44751946, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (45234496..45247145, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (44548506..44560928, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (44958996..44971420, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene IFI30 lysosomal thiol reductase Neighboring gene uncharacterized LOC119864714 Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene interleukin 12 receptor subunit beta 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol 3-kinase regulatory subunit beta; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta
Names
phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    45311340..45323770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428186.1 → XP_038284114.1  phosphatidylinositol 3-kinase regulatory subunit beta

    UniProtKB/TrEMBL
    A0A8C0NQ20, A0A8I3S3N2
    Related
    ENSCAFP00845032484.1, ENSCAFT00845041427.1
    Conserved Domains (5) summary
    cd09930
    Location:613 → 715
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:320 → 430
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:7 → 80
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:435 → 595
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:110 → 294
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    44548506..44560928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038503845.1 → XP_038359773.1  phosphatidylinositol 3-kinase regulatory subunit beta

    Conserved Domains (5) summary
    cd09930
    Location:613 → 715
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:320 → 430
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:7 → 80
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:435 → 595
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:110 → 294
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    44958996..44971420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631009.1 → XP_038486937.1  phosphatidylinositol 3-kinase regulatory subunit beta

    Conserved Domains (5) summary
    cd09930
    Location:613 → 715
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:320 → 430
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:7 → 80
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:435 → 595
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:110 → 294
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    45234496..45247145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038566856.1 → XP_038422784.1  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta

    UniProtKB/TrEMBL
    A0A8C0NQ20, A0A8I3S3N2
    Conserved Domains (5) summary
    cd09930
    Location:613 → 715
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:320 → 430
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:7 → 80
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:435 → 595
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:110 → 294
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44739520..44751946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_847313.6 → XP_852406.2  phosphatidylinositol 3-kinase regulatory subunit beta

    UniProtKB/TrEMBL
    A0A8C0NQ20, A0A8I3S3N2
    Conserved Domains (5) summary
    cd09930
    Location:613 → 715
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:320 → 430
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:7 → 80
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:435 → 595
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:110 → 294
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.