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RPL36A ribosomal protein L36a [ Homo sapiens (human) ]

Gene ID: 6173, updated on 5-Mar-2024

Summary

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Official Symbol
RPL36Aprovided by HGNC
Official Full Name
ribosomal protein L36aprovided by HGNC
Primary source
HGNC:HGNC:10359
See related
Ensembl:ENSG00000241343 MIM:300902; AllianceGenome:HGNC:10359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L36A; L44L; MIG6; eL42; RPL44
Summary
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in ovary (RPKM 91.4), bone marrow (RPKM 73.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RPL36A in Genome Data Viewer
Location:
Xq22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101391011..101396155)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99835123..99840269)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100645999..100651143)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29808 Neighboring gene translocase of inner mitochondrial membrane 8A Neighboring gene Bruton tyrosine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29809 Neighboring gene RPL36A-HNRNPH2 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29811 Neighboring gene galactosidase alpha Neighboring gene heterogeneous nuclear ribonucleoprotein H2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Coupled folding-upon-binding of human tumor suppressor MIG6 to lung cancer EGFR kinase domain and molecular trimming/stapling of MIG6-derived β-hairpins to target the coupling event. He Q, et al. Eur Biophys J, 2023 Feb. PMID 36547692
  2. Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma. Kim JH, et al. Hepatology, 2004 Jan. PMID 14752831
  3. MiR-589-5p is a potential prognostic marker of hepatocellular carcinoma and regulates tumor cell growth by targeting MIG-6. Xu M, et al. Neoplasma, 2018 Sep 19. PMID 30249105
  4. Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress. Kappeler KV, et al. Toxicol Sci, 2012 May. PMID 22367689, Free PMC Article
  5. Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein. Davies MS, et al. Gene, 1986. PMID 3542712

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coupled folding-upon-binding of human tumor suppressor MIG6 to lung cancer EGFR kinase domain and molecular trimming/stapling of MIG6-derived beta-hairpins to target the coupling event.
    Title: Coupled folding-upon-binding of human tumor suppressor MIG6 to lung cancer EGFR kinase domain and molecular trimming/stapling of MIG6-derived β-hairpins to target the coupling event.
  2. miR-589-5p facilitated the growth of liver cancer cells by targeting MIG-6 and could be a prognosis biomarker for hepatocellular carcinoma
    Title: MiR-589-5p is a potential prognostic marker of hepatocellular carcinoma and regulates tumor cell growth by targeting MIG-6.
  3. RPL36A plays a role in tumor cell proliferation and may be a potential target for anticancer therapy of hepatocellular carcinoma
    Title: Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL36A as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72020

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL42
Names
60S ribosomal protein L44
L44-like ribosomal protein
cell growth-inhibiting gene 15 protein
cell migration-inducing gene 6 protein
dJ164F3.3 (ribosomal protein L44)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012523.1 RefSeqGene

    Range
    5052..10196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021029.6 → NP_066357.3  large ribosomal subunit protein eL42

    Status: REVIEWED

    Source sequence(s)
    AL035422, AW150895, BC062219
    Consensus CDS
    CCDS14483.3
    UniProtKB/Swiss-Prot
    P09896, P10661, P83881, Q08ES5, Q5J9I6
    UniProtKB/TrEMBL
    B2R4V2
    Related
    ENSP00000446503.2, ENST00000553110.8
    Conserved Domains (1) summary
    PTZ00157
    Location:1 → 86
    PTZ00157; 60S ribosomal protein L36a; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    101391011..101396155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    99835123..99840269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001199972.1: Suppressed sequence

    Description
    NM_001199972.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83881.2 GenPept UniProtKB/Swiss-Prot:P83881

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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