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RPS5 ribosomal protein S5 [ Homo sapiens (human) ]

Gene ID: 6193, updated on 7-Apr-2024

Summary

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Official Symbol
RPS5provided by HGNC
Official Full Name
ribosomal protein S5provided by HGNC
Primary source
HGNC:HGNC:10426
See related
Ensembl:ENSG00000083845 MIM:603630; AllianceGenome:HGNC:10426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S5; uS7
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 988.2), bone marrow (RPKM 469.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58387269..58394804)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61483659..61491195)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58898636..58906171)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 837 Neighboring gene uncharacterized LOC105372484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58891121-58891662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58891663-58892204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15191 Neighboring gene Sharpr-MPRA regulatory region 7872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15192 Neighboring gene microRNA 4754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15193 Neighboring gene microRNA 10394 Neighboring gene ring finger protein 225 Neighboring gene long intergenic non-protein coding RNA 2560

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function. Qiu L, et al. Int J Mol Sci, 2023 Feb 8. PMID 36834797, Free PMC Article
  2. The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function. Bhat P, et al. Nucleic Acids Res, 2015 Mar 11. PMID 25712089, Free PMC Article
  3. Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol. Iizumi Y, et al. Commun Biol, 2022 Jun 9. PMID 35681048, Free PMC Article
  4. [Mutual effect of human ribosomal proteins S5 and S16 on their binding with 18S rRNA fragment 1203-1236/1521-1698]. Ian'shina DD, et al. Mol Biol (Mosk), 2009 Jul-Aug. PMID 19807034
  5. Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26. Malygin A, et al. Protein Expr Purif, 2003 Mar. PMID 12651107

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unraveling the Role of RNA-Binding Proteins, with a Focus on RPS5, in the Malignant Progression of Hepatocellular Carcinoma.
    Title: Unraveling the Role of RNA-Binding Proteins, with a Focus on RPS5, in the Malignant Progression of Hepatocellular Carcinoma.
  2. KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5.
    Title: KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5.
  3. Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function.
    Title: Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function.
  4. Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol.
    Title: Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol.
  5. Data indicate that beta hairpin structure present in ribosomal protein S5 (RPS5) is important for IRES-RPS5 interaction.
    Title: The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function.
  6. Mutual effect of human ribosomal proteins S5 and S16 on their binding with 18S rRNA fragment 1203-1236/1521-1698
    Title: [Mutual effect of human ribosomal proteins S5 and S16 on their binding with 18S rRNA fragment 1203-1236/1521-1698].
  7. Transfected into yeast cells, plays an important role in maintaining the accuracy of translation.
    Title: Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPS5 as demonstrated by proximity dependent biotinylation proteomics PubMed
Rev rev HIV-1 Rev interacting protein, ribosomal protein S5 (RPS5), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of translational fidelity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit HDA PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS7
Names
40S ribosomal protein S5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009.4 → NP_001000.2  small ribosomal subunit protein uS7

    See identical proteins and their annotated locations for NP_001000.2

    Status: REVIEWED

    Source sequence(s)
    BC015405, BG687415
    Consensus CDS
    CCDS12978.1
    UniProtKB/Swiss-Prot
    B2R4T2, P46782, Q96BN0
    UniProtKB/TrEMBL
    Q53G25
    Related
    ENSP00000196551.3, ENST00000196551.8
    Conserved Domains (1) summary
    cd14867
    Location:18 → 204
    uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58387269..58394804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61483659..61491195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46782.4 GenPept UniProtKB/Swiss-Prot:P46782

Gene LinkOut

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