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RPS27A ribosomal protein S27a [ Homo sapiens (human) ]

Gene ID: 6233, updated on 7-Apr-2024

Summary

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Official Symbol
RPS27Aprovided by HGNC
Official Full Name
ribosomal protein S27aprovided by HGNC
Primary source
HGNC:HGNC:10417
See related
Ensembl:ENSG00000143947 MIM:191343; AllianceGenome:HGNC:10417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBC; S27A; eS31; CEP80; UBA80; HEL112; UBCEP1; UBCEP80
Summary
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in ovary (RPKM 575.2), lymph node (RPKM 347.6) and 25 other tissues See more
Orthologs
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Genomic context

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See RPS27A in Genome Data Viewer
Location:
2p16.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (55231903..55235853)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (55229133..55233083)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (55459039..55462989)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene reticulon 4 Neighboring gene uncharacterized LOC105374662 Neighboring gene Sharpr-MPRA regulatory region 4359 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:55360796-55361708 Neighboring gene CRISPRi-validated cis-regulatory element chr2.2087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15776 Neighboring gene clathrin heavy chain linker domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15778 Neighboring gene CDPF1 pseudogene 1 Neighboring gene mitochondrial translational initiation factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:55496405-55497228 Neighboring gene Sharpr-MPRA regulatory regions 8685 and 822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:55508487-55509380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:55509381-55510272 Neighboring gene prolyl-tRNA synthetase associated domain containing 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Multifaceted functions of RPS27a: An unconventional ribosomal protein. Luo J, et al. J Cell Physiol, 2023 Mar. PMID 36580426
  2. Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases. Khayer N, et al. PLoS One, 2020. PMID 32941527, Free PMC Article
  3. Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line. Almamy A, et al. Immunol Res, 2017 Dec. PMID 28913776
  4. Identification and expression of MMSA-8, and its clinical significance in multiple myeloma. He R, et al. Oncol Rep, 2017 Jun. PMID 28498418, Free PMC Article
  5. RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells. Wang H, et al. Biochem Biophys Res Commun, 2014 Apr 18. PMID 24680683

See all (229) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair.
    Title: UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair.
  2. RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 Signalling.
    Title: RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 Signalling.
  3. Multifaceted functions of RPS27a: An unconventional ribosomal protein.
    Title: Multifaceted functions of RPS27a: An unconventional ribosomal protein.
  4. PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer.
    Title: PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer.
  5. USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.
    Title: USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.
  6. The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells.
    Title: The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells.
  7. Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases.
    Title: Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases.
  8. MTG1 establishes a quality control checkpoint in mitoribosome assembly. In conclusion, MTG1 controls mitochondrial translation by coupling mtLSU assembly with intersubunit bridge formation using the intrinsic GEF activity acquired by the mtSSU through mS27, a unique occurrence in translational systems.
    Title: MTG1 couples mitoribosome large subunit assembly with intersubunit bridge formation.
  9. this study shows that interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line
    Title: Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line.
  10. the full-length cDNA sequence of MMSA-8 was cloned in MM and it was hypothesized that MMSA-8 is MM-associated RPS27A transcript variant 1
    Title: Identification and expression of MMSA-8, and its clinical significance in multiple myeloma.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein S27A (RPS27A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in endosome membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in membrane HDA PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in nucleolus HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle HDA PubMed 

General protein information

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Preferred Names
ubiquitin-ribosomal protein eS31 fusion protein
Names
40S ribosomal protein S27a
epididymis luminal protein 112
ubiquitin C
ubiquitin and ribosomal protein S27a
ubiquitin carboxyl extension protein 80
ubiquitin-40S ribosomal protein S27a
ubiquitin-CEP80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017017.1 RefSeqGene

    Range
    5760..8925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135592.2 → NP_001129064.1  ubiquitin-ribosomal protein eS31 fusion protein precursor

    See identical proteins and their annotated locations for NP_001129064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC012358, AK225079, DB505702
    Consensus CDS
    CCDS33202.1
    UniProtKB/Swiss-Prot
    P14798, P62979, Q9BQ77
    UniProtKB/TrEMBL
    B2RDW1, D6W5C9, Q5RKT7
    Related
    ENSP00000383981.3, ENST00000402285.7
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103 → 147
    Ribosomal_S27; Ribosomal protein S27a

  2. NM_001177413.1 → NP_001170884.1  ubiquitin-ribosomal protein eS31 fusion protein precursor

    See identical proteins and their annotated locations for NP_001170884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC012358, BF678026, DA527860
    Consensus CDS
    CCDS33202.1
    UniProtKB/Swiss-Prot
    P14798, P62979, Q9BQ77
    UniProtKB/TrEMBL
    B2RDW1, D6W5C9, Q5RKT7
    Related
    ENSP00000385659.1, ENST00000404735.1
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103 → 147
    Ribosomal_S27; Ribosomal protein S27a

  3. NM_002954.6 → NP_002945.1  ubiquitin-ribosomal protein eS31 fusion protein precursor

    See identical proteins and their annotated locations for NP_002945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC012358
    Consensus CDS
    CCDS33202.1
    UniProtKB/Swiss-Prot
    P14798, P62979, Q9BQ77
    UniProtKB/TrEMBL
    B2RDW1, D6W5C9, Q5RKT7
    Related
    ENSP00000272317.6, ENST00000272317.11
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103 → 147
    Ribosomal_S27; Ribosomal protein S27a

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    55231903..55235853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    55229133..55233083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62979.2 GenPept UniProtKB/Swiss-Prot:P62979

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