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FAM111A FAM111 trypsin like peptidase A [ Homo sapiens (human) ]

Gene ID: 63901, updated on 23-Mar-2024

Summary

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Official Symbol
FAM111Aprovided by HGNC
Official Full Name
FAM111 trypsin like peptidase Aprovided by HGNC
Primary source
HGNC:HGNC:24725
See related
Ensembl:ENSG00000166801 MIM:615292; AllianceGenome:HGNC:24725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCS2; GCLEB
Summary
The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in spleen (RPKM 18.4), lymph node (RPKM 18.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See FAM111A in Genome Data Viewer
Location:
11q12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59142856..59155039)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59092030..59104213)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58910329..58922512)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4745 Neighboring gene FAM111 trypsin like peptidase B Neighboring gene FAM111A divergent transcript Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4749 Neighboring gene basic proline-rich protein-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58938742-58939282 Neighboring gene Sharpr-MPRA regulatory region 11967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58940291-58941119 Neighboring gene uncharacterized LOC124902675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3362 Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FAM111A-Related Skeletal Dysplasias. Adam MP, et al. , 1993. PMID 37023242
  2. Report of a novel variant in the FAM111A gene in a fetus with multiple anomalies including gracile bones, hypoplastic spleen, and hypomineralized skull. Müller R, et al. Am J Med Genet A, 2021 Jun. PMID 33750016
  3. FAM111A induces nuclear dysfunction in disease and viral restriction. Nie M, et al. EMBO Rep, 2021 Feb 3. PMID 33369867, Free PMC Article
  4. Adult Chinese twins with Kenny-Caffey syndrome type 2: A potential age-dependent phenotype and review of literature. Cheng SSW, et al. Am J Med Genet A, 2021 Feb. PMID 33263187
  5. FAM111A protects replication forks from protein obstacles via its trypsin-like domain. Kojima Y, et al. Nat Commun, 2020 Mar 12. PMID 32165630, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.
    Title: Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.
  2. FAM111A regulates replication origin activation and cell fitness.
    Title: FAM111A regulates replication origin activation and cell fitness.
  3. N[6] -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.
    Title: N(6) -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.
  4. Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1.
    Title: Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1.
  5. IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.
    Title: IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.
  6. Report of a novel variant in the FAM111A gene in a fetus with multiple anomalies including gracile bones, hypoplastic spleen, and hypomineralized skull.
    Title: Report of a novel variant in the FAM111A gene in a fetus with multiple anomalies including gracile bones, hypoplastic spleen, and hypomineralized skull.
  7. Adult Chinese twins with Kenny-Caffey syndrome type 2: A potential age-dependent phenotype and review of literature.
    Title: Adult Chinese twins with Kenny-Caffey syndrome type 2: A potential age-dependent phenotype and review of literature.
  8. FAM111A induces nuclear dysfunction in disease and viral restriction.
    Title: FAM111A induces nuclear dysfunction in disease and viral restriction.
  9. FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease.
    Title: FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease.
  10. These findings reveal a role of FAM111A in overcoming protein obstacles to replication forks.
    Title: FAM111A protects replication forks from protein obstacles via its trypsin-like domain.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22794, KIAA1895, DKFZp686A06175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoprocessing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-DNA covalent cross-linking repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in replication fork processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine protease FAM111A
Names
family with sequence similarity 111 member A
protein FAM111A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042835.1 RefSeqGene

    Range
    5111..17294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142519.3 → NP_001135991.1  serine protease FAM111A

    See identical proteins and their annotated locations for NP_001135991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK025319, AK291453, DA502464, DB218857
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000501786.1, ENST00000674617.1
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  2. NM_001142520.3 → NP_001135992.1  serine protease FAM111A

    See identical proteins and their annotated locations for NP_001135992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. All variants (1-8) encode the same protein.
    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  3. NM_001142521.3 → NP_001135993.1  serine protease FAM111A

    See identical proteins and their annotated locations for NP_001135993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK025319, AK291453, CR747277, DA502464, DB218857
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  4. NM_001312909.2 → NP_001299838.1  serine protease FAM111A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK025319, AK291453, DA326596, DA502464, DB218857, DB234701
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000501952.1, ENST00000675163.1
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  5. NM_001312910.2 → NP_001299839.1  serine protease FAM111A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK025319, AK291453, BQ948815, DA326596
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  6. NM_001312911.2 → NP_001299840.1  serine protease FAM111A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 6. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK025319, AK291453, BQ420366
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000436128.2, ENST00000527629.6
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  7. NM_001369457.1 → NP_001356386.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  8. NM_001374804.1 → NP_001361733.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AK092237, AK092953, BC013137, CN288982, CR749358, DA386492
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000434435.1, ENST00000528737.5
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  9. NM_001374848.1 → NP_001361777.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  10. NM_001374849.1 → NP_001361778.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  11. NM_001374850.1 → NP_001361779.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  12. NM_001374851.1 → NP_001361780.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  13. NM_001374852.1 → NP_001361781.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  14. NM_001374853.1 → NP_001361782.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  15. NM_001374854.1 → NP_001361783.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000501771.1, ENST00000676459.1
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  16. NM_001374855.1 → NP_001361784.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000502754.2, ENST00000529985.3
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  17. NM_001374856.1 → NP_001361785.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000507215.1, ENST00000682018.1
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  18. NM_001374857.1 → NP_001361786.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000501617.2, ENST00000675806.2
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  19. NM_001374858.1 → NP_001361787.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  20. NM_001374859.1 → NP_001361788.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  21. NM_001374860.1 → NP_001361789.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  22. NM_001374861.1 → NP_001361790.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  23. NM_001374862.1 → NP_001361791.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  24. NM_001374863.1 → NP_001361792.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  25. NM_001374864.1 → NP_001361793.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  26. NM_001374865.1 → NP_001361794.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  27. NM_001374866.1 → NP_001361795.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  28. NM_001374867.1 → NP_001361796.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000406683.1, ENST00000420244.6
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  29. NM_001374868.1 → NP_001361797.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000432821.2, ENST00000531408.6
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  30. NM_001374869.1 → NP_001361798.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  31. NM_001374870.1 → NP_001361799.1  serine protease FAM111A

    Status: REVIEWED

    Source sequence(s)
    AP001258
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  32. NM_022074.4 → NP_071357.2  serine protease FAM111A

    See identical proteins and their annotated locations for NP_071357.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK025319, AK291453, DA502464
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000355264.3, ENST00000361723.7
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

  33. NM_198847.3 → NP_942144.1  serine protease FAM111A

    See identical proteins and their annotated locations for NP_942144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK025319, AK291453, DA502464, DB218857
    Consensus CDS
    CCDS7973.1
    UniProtKB/Swiss-Prot
    A8K5Y8, Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q96PZ2, Q9H5Y1
    UniProtKB/TrEMBL
    A0A804HLI8
    Related
    ENSP00000433154.1, ENST00000533703.1
    Conserved Domains (1) summary
    pfam13365
    Location:370 → 555
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    59142856..59155039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    59092030..59104213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001369455.1: Suppressed sequence

    Description
    NM_001369455.1: This RefSeq was removed because it appears to be partial at the 5'' end.

  2. NM_001369456.1: Suppressed sequence

    Description
    NM_001369456.1: This RefSeq was removed because it appears to be partial at the 5'' end.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PZ2.2 GenPept UniProtKB/Swiss-Prot:Q96PZ2

Gene LinkOut

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