PRDM14 PR/SET domain 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRDM14provided by HGNC
Official Full Name: PR/SET domain 14provided by HGNC
Primary source: HGNC:HGNC:14001
See related: Ensembl:ENSG00000147596 MIM:611781; AllianceGenome:HGNC:14001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PFM11
Summary: This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 8q13.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (70051651..70071252, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (70481509..70501107, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (70963886..70983487, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.
Title: YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.
LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via regulation of the miR-27a-3p/PRDM14 axis.
Title: LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via regulation of the miR-27a-3p/PRDM14 axis.
PRDM14 mediates chemosensitivity and glycolysis in drugresistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells.
Title: PRDM14 mediates chemosensitivity and glycolysis in drug‑resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells.
PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.
Title: PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.
PRDM14 targets are not conserved between mouse and human, emphasising the divergent molecular mechanisms of primordial germ cell specification.
Title: A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
PRDM14 is implicated in cancer initiation.[review]
Title: Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14.
RNA interference of PRDM14, a gene expressed by breast cancer cells, reduced the size of tumors and lung metastases in nude mice
Title: Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer.
High PRDM14 expression is associated with Cancer Stemness resulting in lung metastasis in breast cancer.
Title: PRDM14, a Zinc Finger Protein, Regulates Cancer Stemness.
Data show that elevated PRDM14 in PGCLCs causes proliferation and differentiation defects in the germline.
Title: PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.
Our results suggest that PRDM14 serves as an initial trigger for epigenetic changes and hyperdynamic plasticity in tumors via bivalent chromatin domains.
Title: Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of PR domain containing 14 (PRDM14) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PRDM14_3672 (e-PCR)
- UniSTS:462454

SHGC-81111 (e-PCR)
- UniSTS:102331

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in fertilization	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in germ-line stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
involved_in inner cell mass cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PR domain zinc finger protein 14

Names: PR domain 14; PR domain-containing 14; PR domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024504.4 → NP_078780.1 PR domain zinc finger protein 14

See identical proteins and their annotated locations for NP_078780.1

Status: REVIEWED

Source sequence(s)

AF319458, CX166395, CX788380

Consensus CDS

CCDS6206.1

UniProtKB/Swiss-Prot

Q86UX9, Q9GZV8

UniProtKB/TrEMBL

A0A023UFG1

Related

ENSP00000276594.2, ENST00000276594.3

Conserved Domains (4) summary

smart00317
Location:266 → 371

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG5048
Location:460 → 568

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:463 → 483

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:548 → 565

ZF_C2H2; C2H2 Zn finger [structural motif]