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Kcnk13 potassium two pore domain channel subfamily K member 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64120, updated on 13-Apr-2024

Summary

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Official Symbol
Kcnk13provided by RGD
Official Full Name
potassium two pore domain channel subfamily K member 13provided by RGD
Primary source
RGD:68941
See related
Ensembl:ENSRNOG00000047363 AllianceGenome:RGD:68941
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
prdx1; THIK-1
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human KCNK13 (potassium two pore domain channel subfamily K member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 27.2), Brain (RPKM 11.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcnk13 in Genome Data Viewer
Location:
6q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (124970363..125074919)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (119240825..119345292)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (123971030..124077249)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 11 Neighboring gene uncharacterized LOC120103598 Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene uncharacterized LOC120103599 Neighboring gene malate dehydrogenase 1, pseudogene 1 Neighboring gene peroxiredoxin 1, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons. Haskins W, et al. Mol Cell Neurosci, 2017 Sep. PMID 28676376
  2. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol. You C, et al. Alcohol Clin Exp Res, 2021 Jul. PMID 33960499, Free PMC Article
  3. Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1. Madry C, et al. Neuron, 2018 Jan 17. PMID 29290552, Free PMC Article
  4. Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway. Hess A, et al. J Biol Chem, 2003 Nov 14. PMID 12960165
  5. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. Rajan S, et al. J Biol Chem, 2001 Mar 9. PMID 11060316

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
    Title: KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
  2. Inhibiting THIK-1 function depolarizes microglia. Block of THIK-1 function also inhibits release of the pro-inflammatory cytokine interleukin-1beta from activated microglia, consistent with K(+) loss being needed for inflammasome assembly.
    Title: Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1.
  3. DRG neurons of all sizes express THIK1. Cutaneous inflammation downregulates THIK1 expression in only small DRG neurons.
    Title: Cutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons.
  4. THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
    Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium channel subfamily K member 13
Names
potassium channel, subfamily K, member 13
potassium channel, two pore domain subfamily K, member 13
tandem pore domain halothane-inhibited potassium channel 1
tandem pore domain potassium channel THIK-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022293.2 → NP_071629.2  potassium channel subfamily K member 13

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q9ERS0
    UniProtKB/TrEMBL
    A6JEG6, M0RCJ1
    Related
    ENSRNOP00000067310.1, ENSRNOT00000075794.3
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 150
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    124970363..125074919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240447.5 → XP_006240509.1  potassium channel subfamily K member 13 isoform X1

    See identical proteins and their annotated locations for XP_006240509.1

    UniProtKB/Swiss-Prot
    Q9ERS0
    UniProtKB/TrEMBL
    A6JEG6, M0RCJ1
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 150
    Ion_trans_2; Ion channel

  2. XM_063262443.1 → XP_063118513.1  potassium channel subfamily K member 13 isoform X2

  3. XM_039112874.2 → XP_038968802.1  potassium channel subfamily K member 13 isoform X2

    Conserved Domains (1) summary
    pfam07885
    Location:89 → 171
    Ion_trans_2; Ion channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERS0.1 GenPept UniProtKB/Swiss-Prot:Q9ERS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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