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TINAGL1 tubulointerstitial nephritis antigen like 1 [ Homo sapiens (human) ]

Gene ID: 64129, updated on 11-Apr-2024

Summary

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Official Symbol
TINAGL1provided by HGNC
Official Full Name
tubulointerstitial nephritis antigen like 1provided by HGNC
Primary source
HGNC:HGNC:19168
See related
Ensembl:ENSG00000142910 MIM:616064; AllianceGenome:HGNC:19168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARG1; LCN7; LIECG3; TINAGRP
Summary
The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in placenta (RPKM 120.0), fat (RPKM 61.8) and 16 other tissues See more
Orthologs
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Genomic context

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See TINAGL1 in Genome Data Viewer
Location:
1p35.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31576515..31587686)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31434200..31445387)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32042116..32053287)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 645 Neighboring gene uncharacterized LOC124903917 Neighboring gene Sharpr-MPRA regulatory region 14090 Neighboring gene uncharacterized LOC105378626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32034359-32034860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32041927-32042647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 571 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:32070860-32072059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32080194-32080980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32083206-32083895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090464-32090964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090965-32091465 Neighboring gene hypocretin receptor 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32110207-32110977 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene PEF1 and COL16A1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:32123622-32123860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32124291-32124792 Neighboring gene collagen type XVI alpha 1 chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Shen M, et al. Cancer Cell, 2019 Jan 14. PMID 30612941
  2. TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer. Umeyama H, et al. BMC Genomics, 2014. PMID 25521548, Free PMC Article
  3. TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells. Wex T, et al. Biochemistry, 2001 Feb 6. PMID 11170462
  4. Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein. Brömme NC, et al. Biochem Biophys Res Commun, 2000 May 10. PMID 10799322
  5. Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells. Kobayashi M, et al. J Steroid Biochem Mol Biol, 2001 May. PMID 11377975

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin beta1.
    Title: Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1.
  2. Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
    Title: Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
  3. Results show that lower TINAGL1 expression correlates with advanced triple-negative breast cancer (TNBC) tumor stages, reduced disease-free survival (DFS) and distant metastasis-free survival. Consistent with higher risk of metastatic relapse in breast tumors with lower expression of TINAGL1, highly metastatic human breast cancer cell lines express lower TINAGL1 levels than weakly metastatic cells.
    Title: Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
  4. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta.
    Title: Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α.
  5. TINAGL1 and B3GALNT1 are possible candidates for drug compounds that inhibit their gene expression
    Title: TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular matrix structural constituent NAS
Non-traceable Author Statement
more info
 PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosomal transport TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tubulointerstitial nephritis antigen-like
Names
OLRG-2
P3ECSL
TIN Ag-related protein
TIN-Ag-RP
TINAG-like 1
androgen-regulated gene 1
glucocorticoid-inducible protein 5
lipocalin 7
oxidized-LDL responsive gene 2
tubulointerstitial nephritis antigen-related protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028164.1 RefSeqGene

    Range
    5031..16202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204414.2 → NP_001191343.1  tubulointerstitial nephritis antigen-like isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF205436, AK298382
    Consensus CDS
    CCDS55586.1
    UniProtKB/TrEMBL
    B4DVG5
    Related
    ENSP00000395137.2, ENST00000457433.6
    Conserved Domains (2) summary
    cd02620
    Location:173 → 424
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:54 → 94
    Somatomedin_B; Somatomedin B domain

  2. NM_001204415.2 → NP_001191344.1  tubulointerstitial nephritis antigen-like isoform 3

    See identical proteins and their annotated locations for NP_001191344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF205436, AK298382, BM923842
    Consensus CDS
    CCDS72745.1
    UniProtKB/TrEMBL
    F6SDV2
    Related
    ENSP00000445392.2, ENST00000537531.2
    Conserved Domains (2) summary
    cd02620
    Location:99 → 350
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam05375
    Location:12 → 36
    Pacifastin_I; Pacifastin inhibitor (LCMII)

  3. NM_022164.3 → NP_071447.1  tubulointerstitial nephritis antigen-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_071447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC064633, DA656570
    Consensus CDS
    CCDS343.1
    UniProtKB/Swiss-Prot
    A8K9Q5, B4DPK6, D3DPN8, Q8TEJ9, Q8WZ23, Q96GZ4, Q96JW3, Q9GZM7
    UniProtKB/TrEMBL
    B4DVG5
    Related
    ENSP00000271064.7, ENST00000271064.12
    Conserved Domains (3) summary
    cd02620
    Location:204 → 455
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    cl17735
    Location:105 → 140
    VWC; von Willebrand factor type C domain
    cl02508
    Location:54 → 94
    Somatomedin_B; Somatomedin B domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    31576515..31587686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271106.4 → XP_005271163.1  tubulointerstitial nephritis antigen-like isoform X1

    UniProtKB/TrEMBL
    B4DVG5
    Conserved Domains (1) summary
    cl23744
    Location:204 → 364
    Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...

  2. XM_005271107.2 → XP_005271164.1  tubulointerstitial nephritis antigen-like isoform X3

    See identical proteins and their annotated locations for XP_005271164.1

    UniProtKB/TrEMBL
    F6SDV2
    Conserved Domains (2) summary
    cd02620
    Location:99 → 350
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam05375
    Location:12 → 36
    Pacifastin_I; Pacifastin inhibitor (LCMII)

  3. XM_047427608.1 → XP_047283564.1  tubulointerstitial nephritis antigen-like isoform X4

  4. XM_011541946.2 → XP_011540248.2  tubulointerstitial nephritis antigen-like isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    31434200..31445387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338153.1 → XP_054194128.1  tubulointerstitial nephritis antigen-like isoform X1

  2. XM_054338155.1 → XP_054194130.1  tubulointerstitial nephritis antigen-like isoform X3

    UniProtKB/TrEMBL
    F6SDV2

  3. XM_054338156.1 → XP_054194131.1  tubulointerstitial nephritis antigen-like isoform X4

  4. XM_054338154.1 → XP_054194129.1  tubulointerstitial nephritis antigen-like isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZM7.1 GenPept UniProtKB/Swiss-Prot:Q9GZM7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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