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ZNF106 zinc finger protein 106 [ Homo sapiens (human) ]

Gene ID: 64397, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF106provided by HGNC
Official Full Name
zinc finger protein 106provided by HGNC
Primary source
HGNC:HGNC:12886
See related
Ensembl:ENSG00000103994 AllianceGenome:HGNC:12886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SH3BP3; ZFP106; ZNF474
Summary
Enables RNA binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in cytosol and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 62.5), fat (RPKM 20.4) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
15q15.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (42412823..42491141, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40218871..40297183, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42705021..42783339, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucosidase alpha, neutral C Neighboring gene BCL2 interacting protein 3 pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:42652107-42652607 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:42655654-42656620 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42676684-42677239 Neighboring gene uncharacterized LOC105370794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:42677734-42678933 Neighboring gene calpain 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9300 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42749529-42750361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42750362-42751193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9303 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42787505-42788048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42788049-42788592 Neighboring gene synaptosome associated protein 23 Neighboring gene MPRA-validated peak2311 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9304 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis. van den Berg FF, et al. Ann Surg, 2022 Jun 1. PMID 33427755
  2. Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1. Grasberger H, et al. Gene, 2005 Jan 3. PMID 15656981
  3. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Dgany O, et al. Am J Hum Genet, 2002 Dec. PMID 12434312, Free PMC Article
  4. Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP. Contreras-Martos S, et al. Sci Rep, 2017 Jul 5. PMID 28680062, Free PMC Article
  5. An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry. Hecht M, et al. G3 (Bethesda), 2019 Jun 5. PMID 30975701, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis.
    Title: Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis.
  2. Study identified ZFP106 as a novel substrate for CBP-mediated acetylation, and showed that the fully disordered isolated ID3 in CREBBP transiently interacts with an IDR of ZFP106 in a fashion that both IDR regions are maintained.
    Title: Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34610, FLJ45841, DKFZp451A239, DKFZp686N20157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 106
Names
SH3-domain binding protein 3
zinc finger protein 474

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284306.2 → NP_001271235.1  zinc finger protein 106 isoform 2

    See identical proteins and their annotated locations for NP_001271235.1

    Status: REVIEWED

    Source sequence(s)
    AC012651
    Consensus CDS
    CCDS61602.1
    UniProtKB/TrEMBL
    A0A0C4DGM5
    Related
    ENSP00000457637.1, ENST00000565611.5
    Conserved Domains (3) summary
    COG2319
    Location:565 → 993
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:710 → 987
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:760 → 799
    7WD40; WD40 repeat [structural motif]

  2. NM_001284307.4 → NP_001271236.1  zinc finger protein 106 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Consensus CDS
    CCDS61603.1
    UniProtKB/Swiss-Prot
    Q9H2Y7
    Related
    ENSP00000455674.1, ENST00000565380.5
    Conserved Domains (3) summary
    COG2319
    Location:608 → 1036
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:753 → 1030
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:803 → 842
    7WD40; WD40 repeat [structural motif]

  3. NM_001366844.3 → NP_001353773.1  zinc finger protein 106 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    UniProtKB/TrEMBL
    H3BS99
    Related
    ENSP00000456604.1, ENST00000565500.5
    Conserved Domains (3) summary
    cd00200
    Location:666 → 943
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:716 → 755
    7WD40; WD40 repeat [structural motif]
    pfam09184
    Location:539 → 669
    PPP4R2; PPP4R2

  4. NM_001366845.3 → NP_001353774.1  zinc finger protein 106 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Consensus CDS
    CCDS91986.1
    UniProtKB/TrEMBL
    H3BSS6
    Related
    ENSP00000456845.2, ENST00000564754.7
    Conserved Domains (3) summary
    cd00200
    Location:1548 → 1825
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:7 → 29
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:1598 → 1637
    7WD40; WD40 repeat [structural motif]

  5. NM_001366846.3 → NP_001353775.1  zinc finger protein 106 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (3) summary
    cd00200
    Location:1461 → 1738
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:7 → 29
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:1511 → 1550
    7WD40; WD40 repeat [structural motif]

  6. NM_001381993.1 → NP_001368922.1  zinc finger protein 106 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (2) summary
    cd00200
    Location:1481 → 1758
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1531 → 1570
    7WD40; WD40 repeat [structural motif]

  7. NM_001381994.1 → NP_001368923.1  zinc finger protein 106 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (3) summary
    cd00200
    Location:820 → 1097
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:7 → 29
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:870 → 909
    7WD40; WD40 repeat [structural motif]

  8. NM_001381995.1 → NP_001368924.1  zinc finger protein 106 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (2) summary
    cd00200
    Location:759 → 1036
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:809 → 848
    7WD40; WD40 repeat [structural motif]

  9. NM_001381996.1 → NP_001368925.1  zinc finger protein 106 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    UniProtKB/TrEMBL
    H3BS99
    Conserved Domains (2) summary
    sd00039
    Location:657 → 691
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:648 → 879
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. NM_001381997.1 → NP_001368926.1  zinc finger protein 106 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    UniProtKB/TrEMBL
    H3BS99
    Conserved Domains (2) summary
    cd00200
    Location:594 → 871
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:644 → 683
    7WD40; WD40 repeat [structural motif]

  11. NM_001381998.1 → NP_001368927.1  zinc finger protein 106 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    UniProtKB/TrEMBL
    H3BS99
    Conserved Domains (2) summary
    cd00200
    Location:666 → 943
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:716 → 755
    7WD40; WD40 repeat [structural motif]

  12. NM_022473.3 → NP_071918.1  zinc finger protein 106 isoform 1

    See identical proteins and their annotated locations for NP_071918.1

    Status: REVIEWED

    Source sequence(s)
    AC012651
    Consensus CDS
    CCDS32208.1
    UniProtKB/Swiss-Prot
    B4DZ40, E9PE29, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H2Y7, Q9H7B8
    Related
    ENSP00000263805.4, ENST00000263805.8
    Conserved Domains (4) summary
    pfam09528
    Location:302 → 839
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG2319
    Location:1380 → 1808
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:1525 → 1802
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1575 → 1614
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    42412823..42491141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432936.1 → XP_047288892.1  zinc finger protein 106 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    40218871..40297183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378612.1 → XP_054234587.1  zinc finger protein 106 isoform X1

  2. XM_054378613.1 → XP_054234588.1  zinc finger protein 106 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2Y7.1 GenPept UniProtKB/Swiss-Prot:Q9H2Y7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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