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STIL STIL centriolar assembly protein [ Homo sapiens (human) ]

Gene ID: 6491, updated on 3-Apr-2024

Summary

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Official Symbol
STILprovided by HGNC
Official Full Name
STIL centriolar assembly proteinprovided by HGNC
Primary source
HGNC:HGNC:10879
See related
Ensembl:ENSG00000123473 MIM:181590; AllianceGenome:HGNC:10879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIL; MCPH7
Summary
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 3.3), bone marrow (RPKM 3.2) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p33
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (47250139..47314896, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (47128555..47212236, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47715811..47780568, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47657113-47658062 Neighboring gene PDZK1 interacting protein 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:47673792-47674378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47694003-47694964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47694965-47695926 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:47696119-47697092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47697093-47698066 Neighboring gene TAL bHLH transcription factor 1, erythroid differentiation factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47772177-47772742 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47779829-47780558 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:47799401-47800204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47800205-47801008 Neighboring gene cytidine/uridine monophosphate kinase 1 Neighboring gene Sharpr-MPRA regulatory region 7712 Neighboring gene long intergenic non-protein coding RNA 1389 Neighboring gene forkhead box E3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel compound heterozygous variants in the STIL gene identified in a Chinese family with presentation of foetal microcephaly. Cheng C, et al. Eur J Med Genet, 2020 Dec. PMID 33132204
  2. STIL is upregulated in nasopharyngeal carcinoma tissues and promotes nasopharyngeal carcinoma proliferation, migration and invasion. Ouyang Y, et al. Neoplasma, 2020 Jan. PMID 31607137
  3. Knockdown of STIL suppresses the progression of gastric cancer by down-regulating the IGF-1/PI3K/AKT pathway. Wang J, et al. J Cell Mol Med, 2019 Aug. PMID 31187582, Free PMC Article
  4. Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number. Ohta M, et al. Cell Rep, 2018 Jun 12. PMID 29898389
  5. Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer. Rabinowicz N, et al. Oncotarget, 2017 Apr 18. PMID 28423708, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization.
    Title: Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization.
  2. STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer.
    Title: STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer.
  3. Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.
    Title: Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.
  4. circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426.
    Title: circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426.
  5. Novel compound heterozygous variants in the STIL gene identified in a Chinese family with presentation of foetal microcephaly.
    Title: Novel compound heterozygous variants in the STIL gene identified in a Chinese family with presentation of foetal microcephaly.
  6. Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
    Title: Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
  7. Knockdown of STIL suppresses the progression of gastric cancer by down-regulating the IGF-1/PI3K/AKT pathway.
    Title: Knockdown of STIL suppresses the progression of gastric cancer by down-regulating the IGF-1/PI3K/AKT pathway.
  8. these results demonstrate that SFI1 is a centrosomal protein that localizes USP9X to the centrosome to stabilize STIL and promote centriole duplication. We propose that the USP9X protection of STIL to facilitate centriole duplication underlies roles of both proteins in human neurodevelopment.
    Title: SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.
  9. STIL is a key regulator that promotes the proliferation of nasopharyngeal carcinoma
    Title: STIL is upregulated in nasopharyngeal carcinoma tissues and promotes nasopharyngeal carcinoma proliferation, migration and invasion.
  10. The conserved short coiled-coil region of STIL binds to and protects Plk4 from protein degradation at the site of procentriole formation. On the other hand, the conserved C-terminal region of STIL named truncated in microcephaly (TIM) domain promotes autophosphorylation and degradation of adjacent Plk4 by the direct interaction.
    Title: Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microcephaly 7, primary, autosomal recessive
MedGen: C2675187 OMIM: 612703 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686O09161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centrosome duplication IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of left/right symmetry ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryonic axis specification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in floor plate development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in forebrain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart looping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in notochord development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of centriole replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of spindle assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
part_of procentriole replication complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
SCL-interrupting locus protein
Names
SCL/TAL1 interrupting locus
TAL-1-interrupting locus protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012126.1 RefSeqGene

    Range
    5001..69009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001048166.1 → NP_001041631.1  SCL-interrupting locus protein isoform 1

    See identical proteins and their annotated locations for NP_001041631.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA897748, AL135960, CR749851, DA754072, DB062487
    Consensus CDS
    CCDS41329.1
    UniProtKB/TrEMBL
    B7ZLW5
    Related
    ENSP00000360944.3, ENST00000371877.8
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  2. NM_001282936.1 → NP_001269865.1  SCL-interrupting locus protein isoform 2

    See identical proteins and their annotated locations for NP_001269865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction in the 3' coding region compared to variant 1, resulting in an isoform (2) that is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AL135960, AL513322, DB062060, M74558
    Consensus CDS
    CCDS548.1
    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9
    UniProtKB/TrEMBL
    B7ZLW5
    Related
    ENSP00000353544.3, ENST00000360380.7
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  3. NM_001282937.1 → NP_001269866.1  SCL-interrupting locus protein isoform 3

    See identical proteins and their annotated locations for NP_001269866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL135960, AL513322, BC144089, DB062060, M74558
    Consensus CDS
    CCDS72785.1
    UniProtKB/TrEMBL
    B7ZLW5, E9PSF2
    Related
    ENSP00000379523.2, ENST00000396221.6
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  4. NM_001282938.1 → NP_001269867.1  SCL-interrupting locus protein isoform 4

    See identical proteins and their annotated locations for NP_001269867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL135960, BC126223, BC136432, DB062060, M74558
    Consensus CDS
    CCDS72786.1
    UniProtKB/TrEMBL
    A0A0A0MR87, B7ZLW5
    Related
    ENSP00000506981.1, ENST00000682977.1
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 388
    STIL_N; SCL-interrupting locus protein N-terminus

  5. NM_001282939.1 → NP_001269868.1  SCL-interrupting locus protein isoform 5

    See identical proteins and their annotated locations for NP_001269868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate in-frame segment, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL135960, AL513322, BC053615, BC126223, DB062060
    Consensus CDS
    CCDS90946.1
    UniProtKB/TrEMBL
    B7ZLW5, Q5T0C7
    Related
    ENSP00000411664.3, ENST00000447475.7
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 388
    STIL_N; SCL-interrupting locus protein N-terminus

  6. NM_001377417.1 → NP_001364346.1  SCL-interrupting locus protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL135960, AL513322
    Consensus CDS
    CCDS72786.1
    UniProtKB/TrEMBL
    A0A0A0MR87, B7ZLW5
    Related
    ENSP00000337367.6, ENST00000337817.10
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 388
    STIL_N; SCL-interrupting locus protein N-terminus

  7. NM_003035.2 → NP_003026.2  SCL-interrupting locus protein isoform 2

    See identical proteins and their annotated locations for NP_003026.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding region compared to variant 1, resulting in an isoform (2) that is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AA897748, AL135960, DA754072, DB062487, M74558
    Consensus CDS
    CCDS548.1
    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9
    UniProtKB/TrEMBL
    B7ZLW5
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    47250139..47314896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428403.1 → XP_047284359.1  SCL-interrupting locus protein isoform X10

  2. XM_047428312.1 → XP_047284268.1  SCL-interrupting locus protein isoform X1

  3. XM_047428438.1 → XP_047284394.1  SCL-interrupting locus protein isoform X13

  4. XM_047428337.1 → XP_047284293.1  SCL-interrupting locus protein isoform X3

    UniProtKB/TrEMBL
    E9PSF2

  5. XM_047428368.1 → XP_047284324.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  6. XM_047428440.1 → XP_047284396.1  SCL-interrupting locus protein isoform X14

  7. XM_011541998.3 → XP_011540300.1  SCL-interrupting locus protein isoform X6

    See identical proteins and their annotated locations for XP_011540300.1

    UniProtKB/TrEMBL
    B7ZLW5, Q5T0C7
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 388
    STIL_N; SCL-interrupting locus protein N-terminus

  8. XM_047428432.1 → XP_047284388.1  SCL-interrupting locus protein isoform X13

  9. XM_017002123.1 → XP_016857612.1  SCL-interrupting locus protein isoform X5

    UniProtKB/TrEMBL
    B7ZLW5

  10. XM_047428414.1 → XP_047284370.1  SCL-interrupting locus protein isoform X12

  11. XM_017002126.2 → XP_016857615.1  SCL-interrupting locus protein isoform X11

    UniProtKB/TrEMBL
    B1AL49

  12. XM_011541994.3 → XP_011540296.1  SCL-interrupting locus protein isoform X3

    See identical proteins and their annotated locations for XP_011540296.1

    UniProtKB/TrEMBL
    B7ZLW5, E9PSF2
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  13. XM_011542001.2 → XP_011540303.1  SCL-interrupting locus protein isoform X9

    UniProtKB/TrEMBL
    B1AL49
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  14. XM_047428385.1 → XP_047284341.1  SCL-interrupting locus protein isoform X5

  15. XM_047428344.1 → XP_047284300.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  16. XM_047428317.1 → XP_047284273.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  17. XM_006710834.4 → XP_006710897.1  SCL-interrupting locus protein isoform X1

    See identical proteins and their annotated locations for XP_006710897.1

    UniProtKB/TrEMBL
    B7ZLW5
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  18. XM_047428390.1 → XP_047284346.1  SCL-interrupting locus protein isoform X6

    UniProtKB/TrEMBL
    Q5T0C7

  19. XM_047428374.1 → XP_047284330.1  SCL-interrupting locus protein isoform X5

  20. XM_047428343.1 → XP_047284299.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  21. XM_047428314.1 → XP_047284270.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  22. XM_047428300.1 → XP_047284256.1  SCL-interrupting locus protein isoform X1

  23. XM_047428388.1 → XP_047284344.1  SCL-interrupting locus protein isoform X5

  24. XM_047428412.1 → XP_047284368.1  SCL-interrupting locus protein isoform X11

  25. XM_047428336.1 → XP_047284292.1  SCL-interrupting locus protein isoform X3

    UniProtKB/TrEMBL
    E9PSF2

  26. XM_047428316.1 → XP_047284272.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  27. XM_011541992.3 → XP_011540294.1  SCL-interrupting locus protein isoform X1

    See identical proteins and their annotated locations for XP_011540294.1

    UniProtKB/TrEMBL
    B7ZLW5
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  28. XM_047428433.1 → XP_047284389.1  SCL-interrupting locus protein isoform X13

  29. XM_047428348.1 → XP_047284304.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  30. XM_047428304.1 → XP_047284260.1  SCL-interrupting locus protein isoform X1

  31. XM_047428444.1 → XP_047284400.1  SCL-interrupting locus protein isoform X14

  32. XM_047428392.1 → XP_047284348.1  SCL-interrupting locus protein isoform X6

    UniProtKB/TrEMBL
    Q5T0C7

  33. XM_047428377.1 → XP_047284333.1  SCL-interrupting locus protein isoform X5

  34. XM_047428426.1 → XP_047284382.1  SCL-interrupting locus protein isoform X12

  35. XM_047428408.1 → XP_047284364.1  SCL-interrupting locus protein isoform X11

  36. XM_047428331.1 → XP_047284287.1  SCL-interrupting locus protein isoform X3

    UniProtKB/TrEMBL
    E9PSF2

  37. XM_047428404.1 → XP_047284360.1  SCL-interrupting locus protein isoform X10

  38. XM_047428320.1 → XP_047284276.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  39. XM_047428398.1 → XP_047284354.1  SCL-interrupting locus protein isoform X9

  40. XM_011541991.3 → XP_011540293.1  SCL-interrupting locus protein isoform X1

    See identical proteins and their annotated locations for XP_011540293.1

    UniProtKB/TrEMBL
    B7ZLW5
    Conserved Domains (1) summary
    pfam15253
    Location:33 → 435
    STIL_N; SCL-interrupting locus protein N-terminus

  41. XM_047428384.1 → XP_047284340.1  SCL-interrupting locus protein isoform X5

  42. XM_047428417.1 → XP_047284373.1  SCL-interrupting locus protein isoform X12

  43. XM_047428359.1 → XP_047284315.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  44. XM_047428310.1 → XP_047284266.1  SCL-interrupting locus protein isoform X1

  45. XM_017002124.2 → XP_016857613.1  SCL-interrupting locus protein isoform X7

    UniProtKB/TrEMBL
    B7ZLW5

  46. XM_047428394.1 → XP_047284350.1  SCL-interrupting locus protein isoform X8

  47. XM_017002127.1 → XP_016857616.1  SCL-interrupting locus protein isoform X15

    UniProtKB/TrEMBL
    B1AL49

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    47128555..47212236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338350.1 → XP_054194325.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  2. XM_054338364.1 → XP_054194339.1  SCL-interrupting locus protein isoform X5

  3. XM_054338342.1 → XP_054194317.1  SCL-interrupting locus protein isoform X1

  4. XM_054338348.1 → XP_054194323.1  SCL-interrupting locus protein isoform X1

  5. XM_054338386.1 → XP_054194361.1  SCL-interrupting locus protein isoform X13

  6. XM_054338358.1 → XP_054194333.1  SCL-interrupting locus protein isoform X3

    UniProtKB/TrEMBL
    E9PSF2

  7. XM_054338363.1 → XP_054194338.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  8. XM_054338387.1 → XP_054194362.1  SCL-interrupting locus protein isoform X14

  9. XM_054338370.1 → XP_054194345.1  SCL-interrupting locus protein isoform X6

    UniProtKB/TrEMBL
    Q5T0C7

  10. XM_054338384.1 → XP_054194359.1  SCL-interrupting locus protein isoform X13

  11. XM_054338381.1 → XP_054194356.1  SCL-interrupting locus protein isoform X12

  12. XM_054338378.1 → XP_054194353.1  SCL-interrupting locus protein isoform X11

  13. XM_054338355.1 → XP_054194330.1  SCL-interrupting locus protein isoform X3

    UniProtKB/TrEMBL
    E9PSF2

  14. XM_054338375.1 → XP_054194350.1  SCL-interrupting locus protein isoform X9

  15. XM_054338368.1 → XP_054194343.1  SCL-interrupting locus protein isoform X5

  16. XM_054338360.1 → XP_054194335.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  17. XM_054338353.1 → XP_054194328.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  18. XM_054338344.1 → XP_054194319.1  SCL-interrupting locus protein isoform X1

  19. XM_054338371.1 → XP_054194346.1  SCL-interrupting locus protein isoform X6

    UniProtKB/TrEMBL
    Q5T0C7

  20. XM_054338365.1 → XP_054194340.1  SCL-interrupting locus protein isoform X5

  21. XM_054338359.1 → XP_054194334.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  22. XM_054338351.1 → XP_054194326.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  23. XM_054338343.1 → XP_054194318.1  SCL-interrupting locus protein isoform X1

  24. XM_054338369.1 → XP_054194344.1  SCL-interrupting locus protein isoform X5

  25. XM_054338380.1 → XP_054194355.1  SCL-interrupting locus protein isoform X11

  26. XM_054338357.1 → XP_054194332.1  SCL-interrupting locus protein isoform X3

    UniProtKB/TrEMBL
    E9PSF2

  27. XM_054338352.1 → XP_054194327.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  28. XM_054338349.1 → XP_054194324.1  SCL-interrupting locus protein isoform X1

  29. XM_054338385.1 → XP_054194360.1  SCL-interrupting locus protein isoform X13

  30. XM_054338361.1 → XP_054194336.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  31. XM_054338345.1 → XP_054194320.1  SCL-interrupting locus protein isoform X1

  32. XM_054338388.1 → XP_054194363.1  SCL-interrupting locus protein isoform X14

  33. XM_054338372.1 → XP_054194347.1  SCL-interrupting locus protein isoform X6

    UniProtKB/TrEMBL
    Q5T0C7

  34. XM_054338366.1 → XP_054194341.1  SCL-interrupting locus protein isoform X5

  35. XM_054338383.1 → XP_054194358.1  SCL-interrupting locus protein isoform X12

  36. XM_054338379.1 → XP_054194354.1  SCL-interrupting locus protein isoform X11

  37. XM_054338356.1 → XP_054194331.1  SCL-interrupting locus protein isoform X3

    UniProtKB/TrEMBL
    E9PSF2

  38. XM_054338377.1 → XP_054194352.1  SCL-interrupting locus protein isoform X10

  39. XM_054338354.1 → XP_054194329.1  SCL-interrupting locus protein isoform X2

    UniProtKB/Swiss-Prot
    Q15468, Q5T0C5, Q68CN9

  40. XM_054338376.1 → XP_054194351.1  SCL-interrupting locus protein isoform X9

  41. XM_054338346.1 → XP_054194321.1  SCL-interrupting locus protein isoform X1

  42. XM_054338367.1 → XP_054194342.1  SCL-interrupting locus protein isoform X5

  43. XM_054338382.1 → XP_054194357.1  SCL-interrupting locus protein isoform X12

  44. XM_054338362.1 → XP_054194337.1  SCL-interrupting locus protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MR87

  45. XM_054338347.1 → XP_054194322.1  SCL-interrupting locus protein isoform X1

  46. XM_054338373.1 → XP_054194348.1  SCL-interrupting locus protein isoform X7

  47. XM_054338374.1 → XP_054194349.1  SCL-interrupting locus protein isoform X8

  48. XM_054338389.1 → XP_054194364.1  SCL-interrupting locus protein isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15468.2 GenPept UniProtKB/Swiss-Prot:Q15468

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