SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SMARCA2provided by HGNC
Official Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2provided by HGNC
Primary source: HGNC:HGNC:11098
See related: Ensembl:ENSG00000080503 MIM:600014; AllianceGenome:HGNC:11098
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BIS; BRM; SNF2; SWI2; hBRM; NCBRS; Sth1p; BAF190; SNF2L2; SNF2LA; hSNF2a
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in ovary (RPKM 42.5), testis (RPKM 29.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p24.3

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (2015347..2193624)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (2017871..2196087)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (2015347..2193624)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.
Title: Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.
Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.
Title: Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.
Ten-year follow-up of Nicolaides-Baraitser syndrome with a de novo mutation and analysis of 58 gene loci of SMARCA2-associated NCBRS.
Title: Ten-year follow-up of Nicolaides-Baraitser syndrome with a de novo mutation and analysis of 58 gene loci of SMARCA2-associated NCBRS.
SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.
Title: SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.
SMARCA2 deficiency in NSCLC: a clinicopathologic and immunohistochemical analysis of a large series from a single institution.
Title: SMARCA2 deficiency in NSCLC: a clinicopathologic and immunohistochemical analysis of a large series from a single institution.
SWI/SNF chromatin remodeling complex and glucose metabolism are deregulated in advanced bladder cancer.
Title: SWI/SNF chromatin remodeling complex and glucose metabolism are deregulated in advanced bladder cancer.
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca(2+) flux to mitochondria.
Title: SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca(2+) flux to mitochondria.
The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.
Title: The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.
Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.
Title: Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.
SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma.
Title: SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Blepharophimosis-impaired intellectual development syndrome MedGen: C5443984 OMIM: 619293 GeneReviews: Not available	Compare labs
Nicolaides-Baraitser syndrome MedGen: C1303073 OMIM: 601358 GeneReviews: Nicolaides-Baraitser Syndrome	Compare labs

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2013-03-27) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2013-03-27) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants at 1p36 are associated with superior frontal gyrus volume. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Brm-type SWI/SNF chromatin remodeling complex is required for the occasional transcriptional elongation of the HIV-1 provirus in the absence of Tat and for the reactivation of proviral expression from HIV-1 latently infected cells	PubMed
	tat	HIV-1 Tat interacts directly with BRM, a DNA-dependent ATPase subunit of the SWI/SNF chromatin-remodeling complex, to activate the HIV-1 LTR, and this interaction is regulated by Tat lysine 50 acetylation	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2) at amino acid residues 616-617 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-12004 (e-PCR)
- UniSTS:20739

WI-19184 (e-PCR)
- UniSTS:42777

PMC303366P11 (e-PCR)
- UniSTS:272508

D9S2065 (e-PCR)
- UniSTS:12679

SHGC-148225 (e-PCR)
- UniSTS:172957

SMARCA2_2377.2 (e-PCR)
- UniSTS:468140

SHGC-156097 (e-PCR)
- UniSTS:185271

G17342 (e-PCR)
- UniSTS:74937

Smarca2 (e-PCR), detects polymorphism
- UniSTS:516566

D9S143 (e-PCR)
- UniSTS:147171

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	TAS Traceable Author Statement more info	PubMed
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in chromatin remodeling	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in spermatid development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
part_of bBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of brahma complex	NAS Non-traceable Author Statement more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
part_of nBAF complex	ISS Inferred from Sequence or Structural Similarity more info
part_of nBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of npBAF complex	ISS Inferred from Sequence or Structural Similarity more info
part_of npBAF complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: probable global transcription activator SNF2L2

Names: ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated factor 190B; SNF2-alpha; SNF2/SWI2-like protein 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; brahma homolog; global transcription activator homologous sequence; protein brahma homolog; putative global transcription activator SNF2L2; sucrose nonfermenting 2-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032162.2 RefSeqGene

Range

40058..218331

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_882

mRNA and Protein(s)

NM_001289396.2 → NP_001276325.1 probable global transcription activator SNF2L2 isoform a

See identical proteins and their annotated locations for NP_001276325.1

Status: REVIEWED

Source sequence(s)

AL138755, AL359076

Consensus CDS

CCDS34977.1

UniProtKB/Swiss-Prot

B1ALG3, B1ALG4, D3DRH4, D3DRH5, P51531

UniProtKB/TrEMBL

A0A0U1RQZ9

Related

ENSP00000371638.1, ENST00000382203.5

Conserved Domains (10) summary

cd05516
Location:1382 → 1506

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:590 → 632

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:436 → 508

HSA; domain in helicases and associated with SANT domains

cd00046
Location:744 → 883

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:40 → 174

Forkhead_N; Forkhead N-terminal region

pfam00176
Location:727 → 1022

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1049 → 1164

Helicase_C; Helicase conserved C-terminal domain

pfam08880
Location:173 → 207

QLQ; QLQ

pfam14619
Location:1259 → 1326

SnAC; Snf2-ATP coupling, chromatin remodelling complex

cl02556
Location:1333 → 1419

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001289397.2 → NP_001276326.1 probable global transcription activator SNF2L2 isoform c

Status: REVIEWED

Source sequence(s)

BC068252, CA313181, D26155

Consensus CDS

CCDS83338.1

UniProtKB/TrEMBL

A0A0U1RQZ9, F6VDE0

Related

ENSP00000392081.2, ENST00000450198.6

Conserved Domains (10) summary

cd05516
Location:1324 → 1430

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:590 → 632

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:436 → 508

HSA; domain in helicases and associated with SANT domains

cd00046
Location:744 → 872

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:40 → 174

Forkhead_N; Forkhead N-terminal region

pfam00176
Location:727 → 964

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:991 → 1106

Helicase_C; Helicase conserved C-terminal domain

pfam08880
Location:173 → 207

QLQ; QLQ

pfam14619
Location:1201 → 1268

SnAC; Snf2-ATP coupling, chromatin remodelling complex

cl02556
Location:1275 → 1337

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001289398.2 → NP_001276327.1 probable global transcription activator SNF2L2 isoform d

Status: REVIEWED

Source sequence(s)

AL138755, BI758293, CA313181, CD107405, CD513892, DA084762, DA823500

Consensus CDS

CCDS75807.1

UniProtKB/TrEMBL

F6T8Q0

Related

ENSP00000324770.6, ENST00000324954.10

Conserved Domains (2) summary

cd05516
Location:58 → 164

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:9 → 71

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001289399.2 → NP_001276328.1 probable global transcription activator SNF2L2 isoform e precursor

See identical proteins and their annotated locations for NP_001276328.1

Status: REVIEWED

Source sequence(s)

AL138755

Consensus CDS

CCDS83339.1

UniProtKB/TrEMBL

B4DNT1, F6XG14

Related

ENSP00000371620.2, ENST00000382185.6

Conserved Domains (2) summary

cd05516
Location:86 → 192

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:37 → 99

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001289400.2 → NP_001276329.1 probable global transcription activator SNF2L2 isoform f precursor

Status: REVIEWED

Source sequence(s)

AL138755

Consensus CDS

CCDS75808.1

UniProtKB/TrEMBL

B1ALF6

Related

ENSP00000305411.3, ENST00000302401.8

Conserved Domains (2) summary

cd05516
Location:88 → 194

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:39 → 101

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_003070.5 → NP_003061.3 probable global transcription activator SNF2L2 isoform a

See identical proteins and their annotated locations for NP_003061.3

Status: REVIEWED

Source sequence(s)

AK094076, AL558829, BC040029, BC066596, BC068252, X72889

Consensus CDS

CCDS34977.1

UniProtKB/Swiss-Prot

B1ALG3, B1ALG4, D3DRH4, D3DRH5, P51531

UniProtKB/TrEMBL

A0A0U1RQZ9

Related

ENSP00000265773.5, ENST00000349721.8

Conserved Domains (10) summary

cd05516
Location:1382 → 1506

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:590 → 632

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:436 → 508

HSA; domain in helicases and associated with SANT domains

cd00046
Location:744 → 883

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:40 → 174

Forkhead_N; Forkhead N-terminal region

pfam00176
Location:727 → 1022

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1049 → 1164

Helicase_C; Helicase conserved C-terminal domain

pfam08880
Location:173 → 207

QLQ; QLQ

pfam14619
Location:1259 → 1326

SnAC; Snf2-ATP coupling, chromatin remodelling complex

cl02556
Location:1333 → 1419

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_139045.4 → NP_620614.2 probable global transcription activator SNF2L2 isoform b

See identical proteins and their annotated locations for NP_620614.2

Status: REVIEWED

Source sequence(s)

AK094076, BC040029, BC066596, BC068252, X72889

Consensus CDS

CCDS34978.1

UniProtKB/TrEMBL

A0A0U1RQZ9

Related

ENSP00000349788.2, ENST00000357248.8

Conserved Domains (10) summary

cd05516
Location:1382 → 1488

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:590 → 632

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:436 → 508

HSA; domain in helicases and associated with SANT domains

cd00046
Location:744 → 883

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:40 → 174

Forkhead_N; Forkhead N-terminal region

pfam00176
Location:727 → 1022

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1049 → 1164

Helicase_C; Helicase conserved C-terminal domain

pfam08880
Location:173 → 207

QLQ; QLQ

pfam14619
Location:1259 → 1326

SnAC; Snf2-ATP coupling, chromatin remodelling complex

cl02556
Location:1333 → 1395

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.