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Virma vir like m6A methyltransferase associated [ Mus musculus (house mouse) ]

Gene ID: 66185, updated on 11-Apr-2024

Summary

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Official Symbol
Virmaprovided by MGI
Official Full Name
vir like m6A methyltransferase associatedprovided by MGI
Primary source
MGI:MGI:1913435
See related
Ensembl:ENSMUSG00000040720 AllianceGenome:MGI:1913435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1429; mKIAA1429; 1110037F02Rik; 4930422M05Rik
Summary
Predicted to be involved in mRNA alternative polyadenylation and mRNA methylation. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in cytoplasm and nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human VIRMA (vir like m6A methyltransferase associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.4), CNS E11.5 (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Virma in Genome Data Viewer
Location:
4 A1; 4 5.11 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11485958..11551143)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11485958..11551143)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09598 Neighboring gene predicted gene, 35631 Neighboring gene predicted gene 11821 Neighboring gene STARR-positive B cell enhancer ABC_E4613 Neighboring gene STARR-seq mESC enhancer starr_09599 Neighboring gene STARR-positive B cell enhancer ABC_E338 Neighboring gene STARR-seq mESC enhancer starr_09600 Neighboring gene STARR-positive B cell enhancer ABC_E4614 Neighboring gene predicted gene, 53245 Neighboring gene predicted gene, 35693 Neighboring gene RAD54 homolog B (S. cerevisiae) Neighboring gene fibrinogen silencer binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells. Wang L, et al. Cancer Sci, 2023 Apr. PMID 36572002, Free PMC Article
  2. Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m(6)A deposition to activate the PI3K/AKT signaling. Xu CL, et al. Reprod Biol, 2022 Dec. PMID 35987159
  3. Oocyte competence is maintained by m(6)A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development. Hu Y, et al. Cell Death Differ, 2020 Aug. PMID 32094512, Free PMC Article
  4. N(6)-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. Wu Y, et al. Nat Cell Biol, 2022 Jun. PMID 35606490
  5. The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Ito-Kureha T, et al. Nat Immunol, 2022 Aug. PMID 35879451

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells.
    Title: KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells.
  2. Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m[6]A deposition to activate the PI3K/AKT signaling.
    Title: Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m(6)A deposition to activate the PI3K/AKT signaling.
  3. Oocyte competence is maintained by m(6)A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development.
    Title: Oocyte competence is maintained by m(6)A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA alternative polyadenylation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein virilizer homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081183.1 → NP_001074652.1  protein virilizer homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732538, AL772170
    Consensus CDS
    CCDS38693.1
    UniProtKB/TrEMBL
    E9PZY8
    Related
    ENSMUSP00000103943.3, ENSMUST00000108307.3
    Conserved Domains (2) summary
    pfam15502
    Location:1752 → 1857
    MPLKIP; M-phase-specific PLK1-interacting protein
    pfam15912
    Location:5 → 236
    VIR_N; Virilizer, N-terminal

  2. NM_001347055.1 → NP_001333984.1  protein virilizer homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL732538, AL772170
    Consensus CDS
    CCDS84705.1
    UniProtKB/Swiss-Prot
    A2AIV1, A2AIV2, Q3TDQ3, Q3TRR9, Q3U1Z2, Q80TD6, Q8C758, Q8K151, Q9CSI3
    Related
    ENSMUSP00000058078.7, ENSMUST00000059914.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11485958..11551143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AIV2.1 GenPept UniProtKB/Swiss-Prot:A2AIV2

Gene LinkOut

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