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SNRPG small nuclear ribonucleoprotein polypeptide G [ Homo sapiens (human) ]

Gene ID: 6637, updated on 5-Mar-2024

Summary

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Official Symbol
SNRPGprovided by HGNC
Official Full Name
small nuclear ribonucleoprotein polypeptide Gprovided by HGNC
Primary source
HGNC:HGNC:11163
See related
Ensembl:ENSG00000143977 MIM:603542; AllianceGenome:HGNC:11163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMG; Sm-G
Summary
The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in colon (RPKM 14.7), appendix (RPKM 13.1) and 25 other tissues See more
Orthologs
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Genomic context

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See SNRPG in Genome Data Viewer
Location:
2p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70281362..70293740, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70293098..70305490, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70508494..70520872, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11610 Neighboring gene ribosomal protein L39 pseudogene 15 Neighboring gene prenylcysteine oxidase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70519630-70520537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16007 Neighboring gene uncharacterized LOC124906023 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70527535-70528484 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70528485-70529433 Neighboring gene family with sequence similarity 136 member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11612 Neighboring gene Sharpr-MPRA regulatory region 10868 Neighboring gene bromodomain containing 7 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway. Lan Y, et al. Cancer Biol Med, 2020 Feb 15. PMID 32296580, Free PMC Article
  2. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. Heinrichs V, et al. J Mol Biol, 1992 Sep 5. PMID 1387914
  3. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. Conte N, et al. Oncogene, 2002 Aug 15. PMID 12165861
  4. Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core. Plessel G, et al. J Mol Biol, 1997 Jan 17. PMID 9020971
  5. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. Hermann H, et al. EMBO J, 1995 May 1. PMID 7744013, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway.
    Title: Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein polypeptide G (SNRPG), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRPG is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
contributes_to RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 7-methylguanosine cap hypermethylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
involved_in U2-type prespliceosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spliceosomal complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spliceosomal snRNP assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMN-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMN-Sm protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U1 snRNP IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of U1 snRNP NAS
Non-traceable Author Statement
more info
 PubMed 
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP NAS
Non-traceable Author Statement
more info
 PubMed 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4 snRNP NAS
Non-traceable Author Statement
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP NAS
Non-traceable Author Statement
more info
 PubMed 
part_of U7 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of methylosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small nuclear ribonucleoprotein complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of spliceosomal complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex TAS
Traceable Author Statement
more info
 PubMed 
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
small nuclear ribonucleoprotein G
Names
sm protein G
snRNP-G
NP_001304094.1
NP_001304095.1
NP_001304096.1
NP_001304097.1
NP_001304098.1
NP_001304100.1
NP_003087.1
XP_016860263.1
XP_054199495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317165.2 → NP_001304094.1  small nuclear ribonucleoprotein G isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI742299, BP424287, DW428820
    Consensus CDS
    CCDS82463.1
    UniProtKB/TrEMBL
    C9JVQ0
    Related
    ENSP00000393388.1, ENST00000454893.1
    Conserved Domains (1) summary
    cd01719
    Location:5 → 60
    Sm_G; Sm protein G

  2. NM_001317166.2 → NP_001304095.1  small nuclear ribonucleoprotein G isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AI742299, AV682126, BU540400
    UniProtKB/Swiss-Prot
    A8MWD9
    Conserved Domains (1) summary
    cd01719
    Location:5 → 73
    Sm_G; Sm protein G

  3. NM_001317167.1 → NP_001304096.1  small nuclear ribonucleoprotein G isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI290354, AI742299
    Consensus CDS
    CCDS82462.1
    UniProtKB/Swiss-Prot
    A8MWD9
    UniProtKB/TrEMBL
    F5H013
    Related
    ENSP00000416334.2, ENST00000413456.6
    Conserved Domains (1) summary
    cd01719
    Location:4 → 66
    Sm_G; Sm protein G

  4. NM_001317168.1 → NP_001304097.1  small nuclear ribonucleoprotein G isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AI742299, BC035103, HY168189
    Consensus CDS
    CCDS82461.1
    UniProtKB/Swiss-Prot
    A8MWD9
    UniProtKB/TrEMBL
    C9J303, Q49AN9
    Related
    ENSP00000441332.1, ENST00000482975.6
    Conserved Domains (1) summary
    cd01719
    Location:1 → 62
    Sm_G; Sm protein G

  5. NM_001317169.2 → NP_001304098.1  small nuclear ribonucleoprotein G isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains two alternate exons in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AC079338, AI742299, HY168189
    Consensus CDS
    CCDS82461.1
    UniProtKB/Swiss-Prot
    A8MWD9
    UniProtKB/TrEMBL
    C9J303, Q49AN9
    Related
    ENSP00000402194.1, ENST00000438261.5
    Conserved Domains (1) summary
    cd01719
    Location:1 → 62
    Sm_G; Sm protein G

  6. NM_001317171.2 → NP_001304100.1  small nuclear ribonucleoprotein G isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (f) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AI742299, AV682126, CD109295
    Related
    ENST00000429728.1
    Conserved Domains (1) summary
    cd01719
    Location:2 → 56
    Sm_G; Sm protein G

  7. NM_003096.4 → NP_003087.1  small nuclear ribonucleoprotein G isoform a

    See identical proteins and their annotated locations for NP_003087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the highly conserved isoform (a).
    Source sequence(s)
    AI742299, BC106055, DW428820
    Consensus CDS
    CCDS1903.1
    UniProtKB/Swiss-Prot
    A8MWD9, D6W5G6, P62308, Q15357, Q6IB86
    Related
    ENSP00000272348.2, ENST00000272348.7
    Conserved Domains (1) summary
    cd01719
    Location:5 → 74
    Sm_G; Sm protein G

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    70281362..70293740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004774.2 → XP_016860263.1  small nuclear ribonucleoprotein G isoform X1

    UniProtKB/TrEMBL
    C9JVQ0
    Conserved Domains (1) summary
    cd01719
    Location:5 → 60
    Sm_G; Sm protein G

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    70293098..70305490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343520.1 → XP_054199495.1  small nuclear ribonucleoprotein G isoform X1

    UniProtKB/TrEMBL
    C9JVQ0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62308.1 GenPept UniProtKB/Swiss-Prot:P62308

Gene LinkOut

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