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Srp19 signal recognition particle 19 [ Mus musculus (house mouse) ]

Gene ID: 66384, updated on 11-Apr-2024

Summary

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Official Symbol
Srp19provided by MGI
Official Full Name
signal recognition particle 19provided by MGI
Primary source
MGI:MGI:1913634
See related
Ensembl:ENSMUSG00000014504 AllianceGenome:MGI:1913634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310020D23Rik
Summary
Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be located in nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in forelimb bud. Orthologous to human SRP19 (signal recognition particle 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 36.3), liver E14 (RPKM 32.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34464185..34469652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34331121..34336599)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34380446-34380555 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene APC, WNT signaling pathway regulator Neighboring gene STARR-seq mESC enhancer starr_44199 Neighboring gene predicted gene, 54017 Neighboring gene receptor accessory protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E8999 Neighboring gene polycystic kidney disease 2-like 2 Neighboring gene SET translocation pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7S RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal recognition particle 19 kDa protein
NP_079803.2
XP_006526218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025527.3 → NP_079803.2  signal recognition particle 19 kDa protein

    See identical proteins and their annotated locations for NP_079803.2

    Status: VALIDATED

    Source sequence(s)
    AK004118, BX529045
    Consensus CDS
    CCDS37757.1
    UniProtKB/Swiss-Prot
    Q9D7A6
    UniProtKB/TrEMBL
    Q9D104
    Related
    ENSMUSP00000072386.4, ENSMUST00000072576.10
    Conserved Domains (1) summary
    pfam01922
    Location:17 → 115
    SRP19; SRP19 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34464185..34469652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526155.2 → XP_006526218.1  signal recognition particle 19 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_006526218.1

    UniProtKB/Swiss-Prot
    Q9D7A6
    UniProtKB/TrEMBL
    G5E8T3
    Related
    ENSMUSP00000112826.2, ENSMUST00000119329.8
    Conserved Domains (1) summary
    pfam01922
    Location:17 → 91
    SRP19; SRP19 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7A6.1 GenPept UniProtKB/Swiss-Prot:Q9D7A6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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